Professor Sarah Fidler BSc. MBBS. FRCP. PhD

White P, Fox J, MacDonald N, Weber J, McClure M, Fidler S, Ward Het al., 2011, HOW MANY INFECTIONS ARE AVERTED BY BEHAVIOUR CHANGE AFTER EARLY HIV DIAGNOSIS & COUNSELLING OF MSM? ESTIMATES FROM A STOCHASTIC INDIVIDUAL-BASED MODEL, SEXUALLY TRANSMITTED INFECTIONS, Vol: 87, Pages: A51-A52, ISSN: 1368-4973

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Fox J, White PJ, Weber J, Garnett GP, Ward H, Fidler Set al., 2011, Quantifying sexual exposure to HIV within an HIV-serodiscordant relationship: development of an algorithm., AIDS, Vol: 25, Pages: 1065-1082

The risk of acquiring HIV from a single sexual contact varies enormously reflecting biological and behavioural characteristics of both infected and uninfected partners. Accurate information on HIV transmission risk is required to construct evidence-based risk reduction practices for individuals, to direct the provision of prevention strategies at the population level, and enable the definition, quantification and comparison of true exposure in individuals termed 'exposed uninfected' within clinical trials.

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Jones C, Kuldanek K, Black A, Fidler S, Smith Aet al., 2011, Third versus fourth-generation HIV testing: what difference does it really make?, BASHH spring meeting 2011, Pages: 11-11

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kuldanek K, Jones C, Sacks R, Proserpio M, Woodcock T, Fidler S, Smith Aet al., 2011, Enhancing clinical research skills in a genitourinary medicine setting: experience from implementation of a National Institute for Health Research CLAHRC project., BASHH spring meeting 2011, Pages: 34-34

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Ritchie AJ, Campion SL, Kopycinski J, Moodie Z, Wang ZM, Pandya K, Moore S, Liu MKP, Brackenridge S, Kuldanek K, Legg K, Cohen MS, Delwart EL, Haynes BF, Fidler S, McMichael AJ, Goonetilleke Net al., 2011, Differences in HIV-Specific T Cell Responses between HIV-Exposed and -Unexposed HIV-Seronegative Individuals, JOURNAL OF VIROLOGY, Vol: 85, Pages: 3507-3516, ISSN: 0022-538X

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• Citations: 33

Ashby J, Foster C, Garvey L, Wan T, Allsop J, Paramesparan Y, Kocsis A, Hodgson E, Sanger C, Taylor-Robinson S, Fidler S, Winston Aet al., 2011, Cerebral function in perinatally HIV-infected young adults and their HIV-uninfected sibling controls, HIV MEDICINE, Vol: 12, Pages: 11-12, ISSN: 1464-2662

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• Citations: 1

Wan T, Fidler S, McDonald S, Foster Cet al., 2011, Health outcomes for young adults with perinatally acquired HIV-1 infection following transfer to adult services, HIV MEDICINE, Vol: 12, Pages: 12-12, ISSN: 1464-2662

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• Citations: 1

Frize G, Foster C, Fidler S, MacDonald S, Taylor Iet al., 2011, Psychology service evaluation in a clinic for young people (over 16 years) living with HIV and transitioning to adult care, HIV MEDICINE, Vol: 12, Pages: 70-71, ISSN: 1464-2662

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HIV-CAUSAL Collaboration, Cain LE, Logan R, Robins JM, et alet al., 2011, When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study., Ann Intern Med. 2011 Apr 19;154(8):509-15.

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Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PIW, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Carrington M, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DML, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, Deeks SG, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJW, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnset al., 2010, The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation, SCIENCE, Vol: 330, Pages: 1551-1557, ISSN: 0036-8075

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• Citations: 889

Huang K-HG, Bonsall D, Katzourakis A, Thomson EC, Fidler SJ, Main J, Muir D, Weber JN, Frater AJ, Phillips RE, Pybus OG, Goulder PJR, McClure MO, Cooke GS, Klenerman Pet al., 2010, B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection, Nature Communications, Vol: 7

HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1+ patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log10 rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected.

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Foster C, Fidler S, 2010, Optimizing antiretroviral therapy in adolescents with perinatally acquired HIV-1 infection, EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, Vol: 8, Pages: 1403-1416, ISSN: 1478-7210

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• Citations: 21

Barnes E, Flanagan P, Brown A, Robinson N, Brown H, McClure M, Oxenius A, Collier J, Weber J, Guenthard HF, Hirschel B, Fidler S, Phillips R, Frater Jet al., 2010, Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections, JOURNAL OF INFECTIOUS DISEASES, Vol: 202, Pages: 1482-1485, ISSN: 0022-1899

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• Citations: 38

Weber J, Tatoud R, Fidler S, 2010, Postexposure prophylaxis, preexposure prophylaxis or universal test and treat: the strategic use of antiretroviral drugs to prevent HIV acquisition and transmission, AIDS, Vol: 24, Pages: S27-S39, ISSN: 0269-9370

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• Citations: 25

Huang KH, Bonsall D, Katzourakis A, Thomson EC, Fidler SJ, Main J, Muir D, Weber JN, Frater AJ, Phillips RE, Pybus OG, Goulder PJ, McClure MO, Cooke GS, Klenerman Pet al., 2010, B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection., Nat Commun, Vol: 1, ISSN: 2041-1723

HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1(+) patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log(10) rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected.

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Fox J, Castro H, Kaye S, McClure M, Weber JN, Fidler Set al., 2010, Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UK, AIDS, Vol: 24, Pages: 2397-2401, ISSN: 0269-9370

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• Citations: 31

Paramesparan Y, Garvey LJ, Ashby J, Foster CJ, Fidler S, Winston Aet al., 2010, High Rates of Asymptomatic Neurocognitive Impairment in Vertically Acquired HIV-1-Infected Adolescents Surviving to Adulthood, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 55, Pages: 134-136, ISSN: 1525-4135

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• Citations: 33

Hamlyn E, Jones V, Porter K, Fidler Set al., 2010, Antiretroviral treatment of primary HIV infection to reduce onward transmission, CURRENT OPINION IN HIV AND AIDS, Vol: 5, Pages: 283-290, ISSN: 1746-630X

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• Citations: 30

Cohen MS, Fidler S, 2010, HIV prevention 2010: where are we now and where are we going?, CURRENT OPINION IN HIV AND AIDS, Vol: 5, Pages: 265-268, ISSN: 1746-630X

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• Citations: 9

Sharrocks K, Jones C, Naftalin C, Darling D, Fisher M, Fidler S, Fox Jet al., 2010, Accessibility to real time HIV avidity results along with good clinical acumen signifi cantly enhances immediate identifi cation of PHI otherwise missed; an audit of the identifi cation of primary HIV infection (PHI) from 3 large UK HIV centres., IAC 2010

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Sharrocks K, Jones C, Naftalin C, Darling D, Fisher M, Fidler S, Fox Jet al., 2010, Accessibility to real-time HIV avidity results along with good clinical acumen significantly enhances immediate identification of PHI otherwise missed: an audit of the identification of primary HIV infection (PHI) from three large UK HIV centres., British HIV association annual conference, Pages: 2-2

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Sharrocks K, Jones C, Naftalin C, Darling D, Fisher M, Fidler S, Fox Jet al., 2010, Accessibility to real-time HIV avidity results along with good clinical acumen significantly enhances immediate identification of PHI otherwise missed: an audit of the identification of primary HIV infection (PHI) from three large UK HIV centres., British HIV association annual conference, Pages: 2-2

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Sharrocks K, Jones CB, Naftalin C, Darling D, Fisher M, Fidler S, Fox Jet al., 2010, Accessibility to real-time HIV avidity results along with good clinical acumen significantly enhances immediate identification of PHI otherwise missed: an audit of the identification of primary HIV infection (PHI) from three large UK HIV centres, HIV MEDICINE, Vol: 11, Pages: 2-2, ISSN: 1464-2662

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Paramesparan Y, Ashby J, Garvey L, Foster C, Fidler S, Winston Aet al., 2010, High rates of asymptomatic neurocognitive impairment are observed in perinatally HIV-infected adolescents, HIV MEDICINE, Vol: 11, Pages: 11-11, ISSN: 1464-2662

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Hamlyn E, Hickling S, Frater J, Phillips R, Babiker A, McClure M, Fidler Set al., 2010, Protective HLA class I alleles are associated with reduced immune activation and fibrinolysis in individuals with primary HIV infection, HIV MEDICINE, Vol: 11, Pages: 3-3, ISSN: 1464-2662

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Wallis CL, Viana R, St John EP, Simen BB, Ramjee G, Fidler S, Rees H, Weber J, Stevens Wet al., 2010, Presence of low abundance drug-resistant mutations in recently infected HIV-1 subtype C patients from South Africa, International HIV and Hepatitis Virus Drug Resistance and Curative Strategies Workshop, Publisher: INT MEDICAL PRESS LTD, Pages: A35-A35, ISSN: 1359-6535

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• Citations: 2

Fox J, Fidler S, 2010, Sexual transmission of HIV-1, ANTIVIRAL RESEARCH, Vol: 85, Pages: 276-285, ISSN: 0166-3542

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• Citations: 57

Wallis CL, Viana R, St John EP, Simen BB, Ramjee G, Fidler S, Rees H, Weber J, Stevens Wet al., 2010, Presence of low abundance drug-resistant mutations in recently infected HIV-1 subtype C patients from South Africa, Workshop on International HIV and Hepatitis Virus Drug Resistance and Curative Strategies, Publisher: INT MEDICAL PRESS LTD, Pages: A35-A35, ISSN: 1359-6535

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• Citations: 2

Fox J, White PJ, Macdonald N, Weber J, McClure M, Fidler S, Ward Het al., 2009, Reductions in HIV transmission risk behaviour following diagnosis of primary HIV infection: a cohort of high-risk men who have sex with men, HIV MEDICINE, Vol: 10, Pages: 432-438, ISSN: 1464-2662

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• Citations: 124

Wilson SL, Scullard G, Fidler SJ, Weber JN, Poulter NRet al., 2009, Effects of HIV status and antiretroviral therapy on blood pressure, HIV MEDICINE, Vol: 10, Pages: 388-394, ISSN: 1464-2662

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• Citations: 21