Imperial College London
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DrSarahFilippi

Faculty of Natural Sciences, Department of Mathematics

Reader in Statistical Machine Learning
 
 
 
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Contact

 

+44 (0)20 7594 8562s.filippi

 
 
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Location

 

523Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Filippi:2018:10.1098/rsif.2018.0037,
author = {Filippi, SL and Muraro, D and Parker, A and Vaux, L and Almet, A and Fletcher, A and Watson, A and Pin, C and Maini, P and Byrne, H},
doi = {10.1098/rsif.2018.0037},
journal = {Journal of the Royal Society Interface},
title = {Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium},
url = {http://dx.doi.org/10.1098/rsif.2018.0037},
volume = {15},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in invaginations called crypts, and by crypt cell migration onto protrusions called villi; dysregulation of such mechanisms may render the gut susceptible to chronic inflammation. The impact that excessive or misplaced epithelial cell death may have on villus cell migration is currently unknown. We integrated cell-tracking methods with computational models to determine how epithelial homeostasis is affected by acute and chronic TNFα-driven epithelial cell death. Parameter inference reveals that acute inflammatory cell death has a transient effect on epithelial cell dynamics, whereas cell death caused by chronic elevated TNFα causes a delay in the accumulation of labelled cells onto the villus compared to the control. Such a delay may be reproduced by using a cell-based model to simulate the dynamics of each cell in a crypt–villus geometry, showing that a prolonged increase in cell death slows the migration of cells from the crypt to the villus. This investigation highlights which injuries (acute or chronic) may be regenerated and which cause disruption of healthy epithelial homeostasis.
AU  - Filippi,SL
AU  - Muraro,D
AU  - Parker,A
AU  - Vaux,L
AU  - Almet,A
AU  - Fletcher,A
AU  - Watson,A
AU  - Pin,C
AU  - Maini,P
AU  - Byrne,H
DO  - 10.1098/rsif.2018.0037
PY  - 2018///
SN  - 1742-5662
TI  - Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2018.0037
UR  - http://hdl.handle.net/10044/1/62027
VL  - 15
ER  -
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