Imperial College London
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DrSarahFilippi

Faculty of Natural Sciences, Department of Mathematics

Reader in Statistical Machine Learning
 
 
 
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Contact

 

+44 (0)20 7594 8562s.filippi

 
 
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Location

 

523Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sonntag:2019:10.3389/fped.2019.00251,
author = {Sonntag, H-J and Filippi, S and Pipis, S and Custovic, A},
doi = {10.3389/fped.2019.00251},
journal = {Frontiers in Pediatrics},
title = {Blood biomarkers of sensitization and asthma},
url = {http://dx.doi.org/10.3389/fped.2019.00251},
volume = {7},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Biomarkers are essential to determine different phenotypes of childhood asthma, andfor the prediction of response to treatments. In young preschool children with asthma,aeroallergen sensitization, and blood eosinophil count of 300/µL or greater may identifythose who can benefit from the daily use of inhaled corticosteroids (ICS). We proposethat every preschool child who is considered for ICS treatment should have these twofeatures measured as a minimum before a decision is made on the commencementof long-term preventive treatment. In practice, IgE-mediated sensitization should beconsidered as a quantifiable variable, i.e., we should use the titer of sIgE antibodies orthe size of skin prick test response. A number of other blood biomarkers may proveuseful (e.g., allergen-specific IgG/IgE antibody ratios amongst sensitized individuals,component-resolved diagnostics which measures sIgE response to a large number ofallergenic molecules, assessment of immune responses to viruses, level of serum CC16,etc.), but it remains unclear whether these can be translated into clinically useful tests.Going forward, a more integrated approach which takes into account multiple domainsof asthma, from the pattern of symptoms and blood biomarkers to genetic risk andlung function measures, is needed if we are to move toward a stratified approach toasthma management.
AU  - Sonntag,H-J
AU  - Filippi,S
AU  - Pipis,S
AU  - Custovic,A
DO  - 10.3389/fped.2019.00251
PY  - 2019///
SN  - 2296-2360
TI  - Blood biomarkers of sensitization and asthma
T2  - Frontiers in Pediatrics
UR  - http://dx.doi.org/10.3389/fped.2019.00251
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000472225500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71471
VL  - 7
ER  -
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