Publications
355 results found
Pinola P, Morin-Papunen LC, Bloigu A, et al., 2014, Anti-Mullerian hormone: correlation with testosterone and oligo- or amenorrhoea in female adolescence in a population-based cohort study, HUMAN REPRODUCTION, Vol: 29, Pages: 2317-2325, ISSN: 0268-1161
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- Citations: 33
Conway G, Dewailly D, Diamanti-Kandarakis E, et al., 2014, The polycystic ovary syndrome: a position statement from the European Society of Endocrinology, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 171, Pages: P1-P29, ISSN: 0804-4643
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- Citations: 409
Lashen H, Ong K, Dunger DB, et al., 2014, Testosterone levels and FAI in adolescent girls are related to the rate of childhood growth but not to intrauterine growth, 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 75-75, ISSN: 0268-1161
West S, Vaarasmaki M, Piltonen T, et al., 2014, Polycystic ovary syndrome and its symptoms increase the risk of pregnancy complications: population-based cohort study, 30th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 74-75, ISSN: 0268-1161
Laird M, Visser JA, van Houten ELAF, et al., 2014, Ovarian Abnormalities in Androgenized Mice, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Hardy K, Fenwick M, Mora J, et al., 2014, FSH Regulation of Preantral Follicle Growth and Gene Expression in the Mouse Ovary, ENDOCRINE REVIEWS, Vol: 35, ISSN: 0163-769X
Canoy D, Barber TM, Pouta A, et al., 2014, Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 170, Pages: 863-872, ISSN: 0804-4643
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- Citations: 30
Kristensen SG, Andersen K, Clement CA, et al., 2014, Expression of TGF-beta superfamily growth factors, their receptors, the associated SMADs and antagonists in five isolated size-matched populations of pre-antral follicles from normal human ovaries, Molecular Human Reproduction, Vol: 20, Pages: 293-308, ISSN: 1360-9947
In mammals, members of the transforming growth factor-beta (TGF-β) superfamily are known to have key roles in the regulation of follicular growth and development. The aim of the study was to evaluate the expression of TGF-β superfamily growth factors, their receptors, downstream SMAD signalling molecules and TGF-β/bone morphogenetic protein (BMP) antagonists during early human folliculogenesis. Human pre-antral follicles were enzymatically isolated from surplus ovarian tissue obtained from women having ovarian cortical tissue frozen for fertility preservation. A total of 348 human pre-antral follicles, ranging from 40 to 200 µm in diameter, were isolated from ovarian tissue obtained from 15 women, aged 24–34 years. Isolated pre-antral follicles were grouped according to diameter in five size-matched populations spanning the primordial, primary and secondary stage follicles and analysed by whole-genome microarray analysis. Selected proteins/genes were analysed by immunocytochemistry and quantitative RT–PCR. TGF-β superfamily genes with overall highest mRNA expressions levels included growth differentiation factors 9 (GDF9), BMP15, BMP6, BMP-receptor-2 (BMPR2), anti-Müllerian hormone receptor 2 (AMHR2), TGFβR3, inhibin-α (INHA) and intracellular SMAD3 and SMAD4. Moreover, genes which were differentially expressed from the primordial to the late secondary stage follicles included GDF9, BMP15, AMH, INHBB, TGFβR3, SMAD4 and antagonists Follistatin (FST) and GREM1. Collectively, these data indicate that the active TGF-β superfamily pathways in early human folliculogenesis consist of primarily GDF9 combined with possible synergistic effects of BMP15 through the BMPR2 and intracellular activation of SMAD3 and SMAD4, and that AMH and INHBB are engaged in intrafollicular events from the onset of follicular growth. Moreover, the presence of multiple TGF-β/BMP antagonists imply that certain growth factors are
Beale KE, Kinsey-Jones JS, Gardiner JV, et al., 2014, The Physiological Role of Arcuate Kisspeptin Neurons in the Control of Reproductive Function in Female Rats, ENDOCRINOLOGY, Vol: 155, Pages: 1091-1098, ISSN: 0013-7227
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- Citations: 36
West S, Vahasarja M, Bloigu A, et al., 2014, The impact of self-reported oligo-amenorrhea and hirsutism on fertility and lifetime reproductive success: results from the Northern Finland Birth Cohort 1966, HUMAN REPRODUCTION, Vol: 29, Pages: 628-633, ISSN: 0268-1161
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- Citations: 27
Louwers YV, Rayner NW, Herrera BM, et al., 2014, BMI-Associated Alleles Do Not Constitute Risk Alleles for Polycystic Ovary Syndrome Independently of BMI: A Case-Control Study, PLOS ONE, Vol: 9, ISSN: 1932-6203
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- Citations: 13
Comim FV, Hardy K, Franks S, 2013, Adiponectin and Its Receptors in the Ovary: Further Evidence for a Link between Obesity and Hyperandrogenism in Polycystic Ovary Syndrome, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 67
Comim FV, Teerds K, Hardy K, et al., 2013, Increased protein expression of LHCG receptor and 17α-hydroxylase/17-20-lyase in human polycystic ovaries, HUMAN REPRODUCTION, Vol: 28, Pages: 3086-3092, ISSN: 0268-1161
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- Citations: 28
Fenwick MA, Mora JM, Mansour YT, et al., 2013, Investigations of TGF-β Signaling in Preantral Follicles of Female Mice Reveal Differential Roles for Bone Morphogenetic Protein 15, ENDOCRINOLOGY, Vol: 154, Pages: 3423-3436, ISSN: 0013-7227
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- Citations: 36
Barber TM, Franks S, 2013, Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome., Expert Rev Endocrinol Metab, Vol: 8, Pages: 427-429
Sam A, Busbridge M, Amin A, et al., 2013, Hepcidin levels in diabetes mellitus and polycystic ovary syndrome, Diabetic Medicine, Vol: 30, Pages: 1495-1499, ISSN: 0742-3071
Stubbs SA, Webber LJ, Stark J, et al., 2013, Role of Insulin-like Growth Factors in Initiation of Follicle Growth in Normal and Polycystic Human Ovaries, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 98, Pages: 3298-3305, ISSN: 0021-972X
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- Citations: 34
Barber TM, Franks S, 2013, Adipocyte biology in polycystic ovary syndrome, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 373, Pages: 68-76, ISSN: 0303-7207
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- Citations: 64
Franks S, 2013, Special Issue: Polycystic Ovary Syndrome: Models, Manifestations and Management Preface, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 373, Pages: 1-1, ISSN: 0303-7207
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- Citations: 2
Morin-Papunen L, West S, Pinola P, et al., 2013, Menstrual disorders at age 16 are associated with an increased risk of polycystic ovary syndrome and infertility at age 26, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 6-7, ISSN: 0268-1161
Pinola P, Morin-Papunen L, Dunger DB, et al., 2013, AMH levels at age 16 are predictive of future cycle irregularity and hyperandrogenism in girls, 29th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), Publisher: OXFORD UNIV PRESS, Pages: 28-28, ISSN: 0268-1161
Barber TM, Franks S, 2013, Genetics of Polycystic Ovary Syndrome, POLYCYSTIC OVARY SYNDROME: NOVEL INSIGHT INTO CAUSES AND THERAPY, Editors: Macut, Pfeifer, Yildiz, DiamantiKandarakis, Publisher: KARGER, Pages: 28-39, ISBN: 978-3-318-02238-4
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- Citations: 57
Pinola P, Lashen H, Bloigu A, et al., 2012, Menstrual disorders in adolescence: a marker for hyperandrogenaemia and increased metabolic risks in later life? Finnish general population-based birth cohort study, HUMAN REPRODUCTION, Vol: 27, Pages: 3279-3286, ISSN: 0268-1161
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- Citations: 31
Wojciechowski P, Lipowska A, Rys P, et al., 2012, Impact of <i>FTO</i> genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis, DIABETOLOGIA, Vol: 55, Pages: 2636-2645, ISSN: 0012-186X
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- Citations: 66
Wojciechowski P, Lipowska A, Rys P, et al., 2012, Impact of <i>FTO</i> genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis (vol 55, pg 2636, 2012), DIABETOLOGIA, Vol: 55, Pages: 2858-2859, ISSN: 0012-186X
Coviello AD, Haring R, Wellons M, et al., 2012, A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation, PLOS Genetics, Vol: 8, ISSN: 1553-7390
Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroidhormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes(T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide associationstudy (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBGconcentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.86102106), PRMT6 (rs17496332, 1p13.3,p = 1.4610211), GCKR (rs780093, 2p23.3,p= 2.2610216), ZBTB10 (rs440837, 8q21.13,p= 3.4610209), JMJD1C (rs7910927, 10q21.3,p = 6.1610235), SLCO1B1 (rs4149056, 12p12.1, p= 1.9610208), NR2F2 (rs8023580, 15q26.2, p= 8.3610212), ZNF652 (rs2411984,17q21.32, p= 3.5610214), TDGF3 (rs1573036, Xq22.3, p= 4.1610214), LHCGR (rs10454142, 2p16.3, p= 1.3610207), BAIAP2L1(rs3779195, 7q21.3, p= 2.7610208), and UGT2B15 (rs293428, 4q13.2, p= 5.5610206). These genes encompass multiple biologicpathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptorfunction, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer.We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 wassignificant in men only (men p = 2.5610208, women p = 0.66, heterogeneity p = 0.003). Additionally, three loci showed strongsex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger inwomen. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion ofvariance explained at the locus. Using an independent study of 1,129 individual
Franks S, 2012, The investigation and management of hirsutism, JOURNAL OF FAMILY PLANNING AND REPRODUCTIVE HEALTH CARE, Vol: 38, Pages: 182-186, ISSN: 1471-1893
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- Citations: 20
Franks S, 2012, Animal Models and the Developmental Origins of Polycystic Ovary Syndrome: Increasing Evidence for the Role of Androgens in Programming Reproductive and Metabolic Dysfunction, ENDOCRINOLOGY, Vol: 153, Pages: 2536-2538, ISSN: 0013-7227
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- Citations: 38
Baird DT, Balen A, Escobar-Morreale HF, et al., 2012, Health and fertility in World Health Organization group 2 anovulatory women, HUMAN REPRODUCTION UPDATE, Vol: 18, Pages: 586-599, ISSN: 1355-4786
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- Citations: 67
Mora JM, Fenwick MA, Castle L, et al., 2012, Characterization and Significance of Adhesion and Junction-Related Proteins in Mouse Ovarian Follicles, BIOLOGY OF REPRODUCTION, Vol: 86, ISSN: 0006-3363
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- Citations: 88
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