Emeritus ProfessorStephenFranks

Collins J, Diedrich K, Franks S, Geraedts JP, Jacobs PA, Karges B, Kennedy S, Marozzi A, Regan L, Baird DT, Crosignani PG, Devroey P, Diczfalusy E, Evers JL, Fauser BC, Fraser L, Gianaroli L, Glasier A, Liebaers I, Ragni G, Sunde A, Tarlatzis B, Van Steirteghem Aet al., 2008, Genetic aspects of female reproduction, Human Reproduction Update, Vol: 14, Pages: 293-307

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Barber TM, Bennett AJ, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta, Pouta A, Hartikainen AL, Elliott P, Lindgren CM, Freathy RM, Koch K, Ouwehand WH, Karpe F, Conway GS, Wass JA, Järvelin MR, Franks S, McCarthy MIet al., 2008, Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome, Diabetalogia, Vol: 51, Pages: 1153-1158

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Barber TM, Hazell M, Christodoulides C, Golding SJ, Alvey C, Burling K, Vidal-Puig A, Groome NP, Wass JA, Franks S, McCarthy MIet al., 2008, Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition, Journal of Clinical Endocrinology and Metabolism, Vol: 97, Pages: 2859-2865

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Franks S, 2008, Polycystic ovary syndrome in adolescents, INTERNATIONAL JOURNAL OF OBESITY, Vol: 32, Pages: 1035-1041, ISSN: 0307-0565

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• Citations: 121

Franks S, Stark J, Hardy K, 2008, Follicle dynamics and anovulation in polycystic ovary syndrome, HUMAN REPRODUCTION UPDATE, Vol: 14, Pages: 367-378, ISSN: 1355-4786

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• Citations: 381

Collins J, Diedrich K, Franks S, Geraedts JPM, Jacobs PA, Karges B, Kennedy S, Marozzi A, Regan L, Baird DT, Crosignani PG, Devroey P, Diczfalusy E, Evers JLH, Fauser BCJM, Fraser L, Gianaroli L, Glasier A, Liebaers I, Ragni G, Sunde A, Tarlatzis B, Van Steirteghem Aet al., 2008, Genetic aspects of female reproduction, HUMAN REPRODUCTION UPDATE, Vol: 14, Pages: 293-307, ISSN: 1355-4786

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• Citations: 51

Barber TM, Casanueva FF, Karpe F, Lage M, Franks S, McCarthy MI, Wass JAHet al., 2008, Ghrelin levels are suppressed and show a blunted response to oral glucose in women with polycystic ovary syndrome, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 158, Pages: 511-516, ISSN: 0804-4643

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• Citations: 39

Barber TM, Golding SJ, Alvey C, Wass JA, Karpe F, Franks S, McCarthy MIet al., 2008, Global adiposity rather than abnormal regional fat distribution characterizes women with polycystic ovary syndrome, Journal of Clinical Endocrinology and Metabolism, Vol: 93, Pages: 999-1004

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Tarlatzis BC, Fauser BC, Legro RS, Norman RJ, Hoeger K, Pasquali R, Franks S, Messinis I, Casper R, Homburg R, Lobo R, Rebar R, Fleming R, Carr B, Bouchard P, Chang RJ, Hugues JN, Azziz R, Kolibianakis EM, Griesinger G, Diedrich K, Balen A, Farquhar C, Devroey P, Ho PC, Collins J, Goulis DG, Eijkemans R, Crosignani PG, DeCherney A, Van Steirteghem Aet al., 2008, Consensus on infertility treatment related to polycystic ovary syndrome, Human Reproduction, Vol: 23, Pages: 462-477

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Franks S, Layton A, Glasier A, 2008, Cyproterone acetate/ethinyl estradiol for acne and hirsutism: time to revise prescribing policy, HUMAN REPRODUCTION, Vol: 23, Pages: 231-232, ISSN: 0268-1161

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• Citations: 26

Bennett AJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Hartkainen AL, Franks S, Elliott P, Jarvelin MR, McCarthy MIet al., 2008, No evidence that established type 2 diabetes susceptiblity variants in the PPARG and KCNJ11 gene have pleiotropic effects on early growth, Diabetologia, Vol: 51, Pages: 82-85

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Franks S, 2007, How good are we at diagnosing polycystic ovary syndrome?, CLINICAL ENDOCRINOLOGY, Vol: 67, Pages: 809-810, ISSN: 0300-0664

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• Citations: 2

Stubbs SA, Stark J, Dilworth SM, Franks S, Hardy Ket al., 2007, Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 92, Pages: 4418-4426, ISSN: 0021-972X

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• Citations: 84

Hart R, Sloboda DM, Doherty DA, Norman R, Franks S, Newnham J, Dickinson J, Hickey Met al., 2007, The effect of intrauterine exposure to maternal androgens on the incidence of Polycystic Ovarian Syndrome in a cohort of Australian adolescents - The Raine cohort, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S54-S54, ISSN: 0378-3782

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Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI, Lingard SJ, Diakonov I, Patterson M, Ghatei M, Bloom SR, Franks S, Huhtaniemi I, Hardy K, Withers DJet al., 2007, Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse, BIOLOGY OF REPRODUCTION, Vol: 76, Pages: 1045-1053, ISSN: 0006-3363

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• Citations: 23

Barber TM, Bennett AJ, Gloyn AL, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Weedon MN, Hartikainen A-L, Wass JAH, Jarvelin M-R, Zeggini E, Franks S, McCarthy MIet al., 2007, Relationship between E23K (an established type II diabetes-susceptibility variant within <i>KCNJ11</i>), polycystic ovary syndrome and androgen levels, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 15, Pages: 679-684, ISSN: 1018-4813

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• Citations: 12

Webber LJ, Stubbs SA, Stark J, Margara RA, Trew GH, Lavery SA, Hardy K, Franks Set al., 2007, Prolonged survival in culture of preantral follicles from polycystic ovaries, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 92, Pages: 1975-1978, ISSN: 0021-972X

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• Citations: 66

Barber TM, Wass JAH, McCarthy MI, Franks Set al., 2007, Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome, CLINICAL ENDOCRINOLOGY, Vol: 66, Pages: 513-517, ISSN: 0300-0664

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• Citations: 190

Forsdike RA, Hardy K, Bull L, Stark J, Webber LJ, Stubbs S, Robinson JE, Franks Set al., 2007, Disordered follicle development in ovaries of prenatally androgenized ewes, JOURNAL OF ENDOCRINOLOGY, Vol: 192, Pages: 421-428, ISSN: 0022-0795

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• Citations: 71

Barber TM, Bennett AJ, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Hartikainen AL, Elliott P, Wass JAH, Jarvelin MR, Zeggini E, Franks S, McCarthy MIet al., 2007, Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants withinthe TCF7L2 gene and PCOS, Diabetologia, Vol: 50, Pages: 2318-2322

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Kousta E, Franks S, 2007, Long-term health consequences of polycystic ovary syndrome, POLYCYSTIC OVARY SYNDROME, 2ND EDITION, Editors: Kovacs, Norman, Publisher: CAMBRIDGE UNIV PRESS, Pages: 81-101

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• Citations: 4

Franks S, 2007, Anovulation in Polycystic Ovary Syndrome, INSULIN RESISTANCE AND POLYCYSTIC OVARIAN SYNDROME: PATHOGENESIS, EVALUATION, AND TREATMENT, Editors: DiamantiKandarakis, Nestler, Panidis, Pasquali, Publisher: HUMANA PRESS INC, Pages: 299-304, ISBN: 978-1-58829-763-1

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• Citations: 1

Das S, Bennett AJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Hartikainen AL, Franks S, Elliott P, Poulton J, Jarvelin MR, McCarthy MIet al., 2007, Detailed analysis of variation around mitochondrial position 16189 in a large Finnish cohort reveals no significant associations with early growth or metabolic phenotypes at age 31 years, Journal of Clinical Endocrinology & Metabolism, Vol: 92, Pages: 3219-3223

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Sorensen MB, Franks S, Robertson C, Pennell DJ, Collins Pet al., 2006, Severe endothelial dysfunction in young women with polycystic ovary syndrome is only partially explained by known cardiovascular risk factors, CLINICAL ENDOCRINOLOGY, Vol: 65, Pages: 655-659, ISSN: 0300-0664

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• Citations: 41

Roy P, Franks S, Read M, Huhtaniemi ITet al., 2006, Determination of androgen bioactivity in human serum samples using a recombinant cell based <i>in vitro</i> bioassay, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol: 101, Pages: 68-77, ISSN: 0960-0760

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• Citations: 21

Barber TM, McCarthy MI, Wass JAH, Franks Set al., 2006, Obesity and polycystic ovary syndrome, Clinical Endocrinology, Vol: 65, Pages: 137-145, ISSN: 0300-0664

The aetiology of Polycystic Ovary Syndrome (PCOS) is complex and multifactorial. There is much evidence, however, to suggest that adipose tissue plays an important role in the development and maintenance of PCOS pathology. There is a close correlation between adiposity and symptom severity in women with PCOS, and even modest reductions in weight generally translate into significant improvements in menstrual regularity, fertility and hyperandrogenic features. This review article considers the various mechanisms that might underlie this link between excess adiposity and PCOS – including the effects of differential insulin sensitivity, abnormal steroid hormone metabolism and adipocytokine secretion. Greater attention to the therapeutic options available to reduce the impact of excess adiposity on ovarian and metabolic function is essential to the management of PCOS.

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Gorry A, White DM, Franks S, 2006, Infertility in polycystic ovary syndrome - Focus on low-dose gonadotropin treatment, ENDOCRINE, Vol: 30, Pages: 27-33, ISSN: 1355-008X

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• Citations: 62

Franks S, 2006, Candidate genes in women with polycystic ovary syndrome, FERTILITY AND STERILITY, Vol: 86, Pages: S15-S15, ISSN: 0015-0282

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• Citations: 3

Draper N, Powell BL, Franks S, Conway GS, Stewart PM, McCarthy MIet al., 2006, Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome, CLINICAL ENDOCRINOLOGY, Vol: 65, Pages: 64-70, ISSN: 0300-0664

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• Citations: 23

Koivunen R, Pouta A, Franks S, Sovio U, Hartikainen AL, McCarthy MI, Ruokonen A, Martikainen H, Jarvelin MR, Morin-Papunen Let al., 2006, Fecundability and miscarriages in women with self-reported symptoms of oligomenorrhoea and/or hirsutism: Northern Finland birth cohort 1966 study, 22nd Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology, Publisher: OXFORD UNIV PRESS, Pages: I103-I104, ISSN: 0268-1161

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