Emeritus ProfessorStephenFranks

Joseph-Horne R, Mason H, Batty S, White D, Hillier S, Urquhart M, Franks Set al., 2002, Luteal phase progesterone excretion in ovulatory women with polycystic ovaries, HUMAN REPRODUCTION, Vol: 17, Pages: 1459-1463, ISSN: 0268-1161

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• Citations: 36

Nardo LG, Buckett WM, White D, Digesu AG, Franks S, Khullar Vet al., 2002, Three-dimensional assessment of ultrasound features in women with clomiphene citrate-resistant polycystic ovarian syndrome (PCOS): ovarian stromal volume does not correlate with biochemical indices, HUMAN REPRODUCTION, Vol: 17, Pages: 1052-1055, ISSN: 0268-1161

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• Citations: 18

Gilling-Smith C, Franks S, 2002, Hirsutism, Oxford Textbook of Endocrinology and Diabetes, Pages: 1148-1159, ISBN: 9780192630452

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Gilling-Smith C, Franks S, 2002, Ovary, Comprehensive Clinical Endocrinology, Pages: 375-393, ISBN: 9780723431855

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Webber LJ, Franks S, 2002, The breast, Oxford Textbook of Endocrinology and Diabetes, Pages: 1202-1213, ISBN: 9780192630452

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Franks S, Cela E, Gharani N, Waterworth D, McCarthy Met al., 2002, Polycystic ovary syndrome:candidate genes for hyperandrogenism and hyperinsulinaemia, Genetics in Endocrinology, Pages: 267-273, ISBN: 9780781714969

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Franks S, Gharani N, McCarthy M, 2002, Role of genes encoding steroidogenic enzymes in polycystic ovary syndrome, Polycystic Ovary Syndrome, Pages: 247-259, ISBN: 9780824707460

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Sharpe RM, Franks S, 2002, Environment, lifestyle and infertility - an inter-generational issue, NATURE MEDICINE, Vol: 8, Pages: 33-40, ISSN: 1078-8956

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• Citations: 19

Gilling-Smith C, Franks S, 2002, Ovary, In Comprehensive Clinical Endocrinology, Editors: Thorner, Besser, London, Publisher: Mosby, Pages: 375-393

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Franks S, White DM, 2002, Low-dose gonadotrophin treatment in polycystic ovary syndrome:the 'step-up' protocol, Ovulation Induction (Series-European practice in gynaecology and obstetrics,3), ISBN: 9782842993160

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Franks S, 2002, Female endocrinology, Oxford textbook of endocrinology and diabetes, Pages: 1063-1226, ISBN: 9780192630452

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Franks S, 2001, Are women with polycystic ovary syndrome at increased risk of cardiovascular disease? Too early to be sure, but not too early to act!, AMERICAN JOURNAL OF MEDICINE, Vol: 111, Pages: 665-666, ISSN: 0002-9343

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• Citations: 9

Haddad L, Evans J, Franks S, McCarthy MIet al., 2001, Variation at the calpain 10 gene implicated in Type 2 diabetes susceptibility, plays no role in the pathogenesis of polycystic ovary syndrome., AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 69, Pages: 567-567, ISSN: 0002-9297

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Clément F, Monniaux D, Stark J, Hardy K, Thalabard JC, Franks S, Claude Det al., 2001, Mathematical model of FSH-induced cAMP production in ovarian follicles, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 281, Pages: E35-E53, ISSN: 0193-1849

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• Citations: 25

Clément F, Monniaux D, Stark J, Hardy K, Thalabard JC, Franks S, Claude Det al., 2001, Mathematical model of FSH-induced cAMP production in ovarian follicles., Am J Physiol Endocrinol Metab, Vol: 281, Pages: E35-E53, ISSN: 0193-1849

During the terminal part of their development, ovarian follicles become totally dependent on gonadotropin supply to pursue their growth and maturation. Both gonadotropins, follicle-stimulating hormone (FSH) and luteining hormone (LH), operate mainly through stimulatory G protein-coupled receptors, their signal being transduced by the activation of the enzyme adenylyl cyclase and the production of second-messenger cAMP. In this paper, we develop a mathematical model of the dynamics of the coupling between FSH receptor stimulation and cAMP synthesis. This model takes the form of a set of nonlinear, ordinary differential equations that describe the changes in the different states of FSH receptors (free, bound, phosphorylated, and internalized), coupling efficiency (activated adenylyl cyclase), and cAMP response. Classical analysis shows that, in the case of constant FSH signal input, the system converges to a unique, stable equilibrium state, whose properties are here investigated. The system also appears to be robust to nonconstant input. Particular attention is given to the influence of biologically relevant parameters on cAMP dynamics.

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Franks S, Gharani N, McCarthy M, 2001, Genetics and infertility II - Candidate genes in polycystic ovary syndrome, HUMAN REPRODUCTION UPDATE, Vol: 7, Pages: 405-410, ISSN: 1355-4786

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• Citations: 92

Russell SH, Small CJ, Stanley SA, Franks S, Ghatei MA, Bloom SRet al., 2001, The <i>in vitro</i> role of tumour necrosis factor-alpha and interleukin-6 in the hypothalamic-pituitary gonadal axis, JOURNAL OF NEUROENDOCRINOLOGY, Vol: 13, Pages: 296-301, ISSN: 0953-8194

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• Citations: 51

Franks S, 2001, Abnormalities of steroidogenesis in polycystic ovaries., BIOLOGY OF REPRODUCTION, Vol: 64, Pages: 86-86, ISSN: 0006-3363

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Franks S, 2000, Is there a doctor on the plane?, MEDICAL EDUCATION, Vol: 34, Pages: 1043-1043, ISSN: 0308-0110

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Gilling-Smith C, Mason H, Willis D, Franks S, Beard RWet al., 2000, In-vitro ovarian steroidogenesis in women with pelvic congestion, HUMAN REPRODUCTION, Vol: 15, Pages: 2570-2576, ISSN: 0268-1161

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• Citations: 3

Bonser J, Walker J, Purohit A, Reed MJ, Potter BVL, Willis DS, Franks S, Mason HDet al., 2000, Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production, JOURNAL OF ENDOCRINOLOGY, Vol: 167, Pages: 465-471, ISSN: 0022-0795

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• Citations: 28

Kousta E, Cela E, Lawrence N, Penny A, Millauer B, White D, Wilson H, Robinson S, Johnston D, McCarthy M, Franks Set al., 2000, The prevalence of polycystic ovaries in women with a history of gestational diabetes, CLINICAL ENDOCRINOLOGY, Vol: 53, Pages: 501-507, ISSN: 0300-0664

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• Citations: 63

Franks S, Mason H, Willis D, 2000, Follicular dynamics in the polycystic ovary syndrome, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 163, Pages: 49-52, ISSN: 0303-7207

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• Citations: 156

Franks S, Gilling-Smith C, Gharani N, McCarthy Met al., 2000, Pathogenesis of polycystic ovary syndrome: evidence for a genetically determined disorder of ovarian androgen production., Hum Fertil (Camb), Vol: 3, Pages: 77-79

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women of reproductive age. It is the major cause of anovulatory infertility and of hirsutism but its aetiology remains uncertain. The most consistent biochemical abnormality is hypersecretion of androgens. In this review, evidence is presented to support the view that a genetically determined abnormality of ovarian androgen secretion is the primary cause of the syndrome. Molecular genetic studies have demonstrated that CYP11a, the gene encoding P450 cholesterol side chain cleavage, is a major susceptibility locus for development of hyperandrogenism in PCOS.

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Hardy K, Wright CS, Franks S, Winston RMLet al., 2000, <i>In vitro</i> maturation of oocytes, BRITISH MEDICAL BULLETIN, Vol: 56, Pages: 588-602, ISSN: 0007-1420

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• Citations: 49

Kousta E, White DM, Cela E, McCarthy MI, Franks Set al., 1999, The prevalence of polycystic ovaries in women with infertility, HUMAN REPRODUCTION, Vol: 14, Pages: 2720-2723, ISSN: 0268-1161

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• Citations: 76

Franks S, Gharani N, McCarthy T, 1999, Genetic abnormalities in polycystic ovary syndrome, ANNALES D ENDOCRINOLOGIE, Vol: 60, Pages: 131-133, ISSN: 0003-4266

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• Citations: 23

Franks S, Gilling-Smith C, Watson H, Willis Det al., 1999, Insulin action in the normal and polycystic ovary, ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, Vol: 28, Pages: 361-+, ISSN: 0889-8529

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• Citations: 163

Wright CS, Margara R, Trew G, Winston RML, Franks S, Hardy Ket al., 1999, The development and hormone production of small human ovarian follicles <i>in vitro</i>, HUMAN REPRODUCTION, Vol: 14, Pages: 16-17, ISSN: 0268-1161

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Wright CS, Hovatta O, Margara R, Trew G, Winston RML, Franks S, Hardy Ket al., 1999, Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles, HUMAN REPRODUCTION, Vol: 14, Pages: 1555-1562, ISSN: 0268-1161

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• Citations: 197