Publications
355 results found
Franks S, 2006, Genetic and environmental origins of obesity relevant to reproduction, REPRODUCTIVE BIOMEDICINE ONLINE, Vol: 12, Pages: 526-531, ISSN: 1472-6483
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- Citations: 37
Franks S, 2006, Diagnosis of polycystic ovarian syndrome: In defense of the Rotterdam criteria, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 91, Pages: 786-789, ISSN: 0021-972X
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- Citations: 176
Franks S, McCarthy MI, Hardy K, 2006, Development of polycystic ovary syndrome: involvement of genetic and environmental factors, INTERNATIONAL JOURNAL OF ANDROLOGY, Vol: 29, Pages: 278-284, ISSN: 0105-6263
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- Citations: 188
Smith D, Crotty TB, Murphy JF, et al., 2006, A steroid cell tumor outside the ovary is a rare cause of virilization, FERTILITY AND STERILITY, Vol: 85, ISSN: 0015-0282
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- Citations: 7
Stubbs SA, Hardy K, Da Silva-Buttkus P, et al., 2005, Anti-Mullerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 90, Pages: 5536-5543, ISSN: 0021-972X
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- Citations: 127
Bennett A, Sovio U, Ruokonen A, et al., 2005, No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort, DIABETOLOGIA, Vol: 48, Pages: 886-891, ISSN: 0012-186X
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- Citations: 15
Powell BL, Haddad L, Bennett A, et al., 2005, Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 90, Pages: 2988-2993, ISSN: 0021-972X
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- Citations: 53
Rice S, Christoforidis N, Gadd C, et al., 2005, Impaired insulin-dependent glucose metabolism in granulosa-lutein cells from anovulatory women with polycystic ovaries, HUMAN REPRODUCTION, Vol: 20, Pages: 373-381, ISSN: 0268-1161
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- Citations: 155
Taponen S, Martikainen H, Järvelin MR, et al., 2005, Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study, Obstetrical and Gynecological Survey, Vol: 60, Pages: 37-39, ISSN: 0029-7828
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- Citations: 2
Roberts R, Iatropoulou A, Ciantar D, et al., 2005, Follicle-stimulating hormone affects metaphase I chromosome alignment and increases aneuploidy in mouse oocytes matured in vitro, BIOLOGY OF REPRODUCTION, Vol: 72, Pages: 107-118, ISSN: 0006-3363
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- Citations: 120
Bennett AJ, Sovio U, Ruokonen A, et al., 2005, TNFalpha promoter variants-238 and-308, early growth and adult metabolic phenotypes: No associations observed in a large Finnish birth cohort, 65th Annual Meeting of the American-Diabetes-Association, Publisher: AMER DIABETES ASSOC, Pages: A289-A289, ISSN: 0012-1797
Hart R, Hickey M, Franks S, 2004, Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome, BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, Vol: 18, Pages: 671-683, ISSN: 1521-6934
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- Citations: 212
Roberts R, Stark J, Iatropoulou A, et al., 2004, Energy substrate metabolism of mouse cumulus-clocyte complexes: Response to follicle-stimulating hormone is mediated by the phosphatidylinositol 3-kinase pathway and is associated with oocyte maturation, BIOLOGY OF REPRODUCTION, Vol: 71, Pages: 199-209, ISSN: 0006-3363
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- Citations: 54
Gaasenbeek M, Powell BL, Sovio U, et al., 2004, Large-scale analysis of the relationship between <i>CYP11A</i> promoter variation, polycystic ovarian syndrome, and serum testosterone, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 89, Pages: 2408-2413, ISSN: 0021-972X
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- Citations: 77
Taponen S, Ahonkallio S, Martikainen H, et al., 2004, Prevalence of polycystic ovaries in women with self-reported symptoms of oligomenorrhoea and/or hirsutism:: Northern Finland Birth Cohort 1966 Study, HUMAN REPRODUCTION, Vol: 19, Pages: 1083-1088, ISSN: 0268-1161
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- Citations: 73
Taponen S, Martikainen H, Järvelin MR, et al., 2004, Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism:: Northern Finland Birth Cohort 1966 Study, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 89, Pages: 2114-2118, ISSN: 0021-972X
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- Citations: 79
Franks S, McCarthy M, 2004, Genetics of ovarian disorders: Polycystic ovary syndrome, REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, Vol: 5, Pages: 69-76, ISSN: 1389-9155
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- Citations: 54
Cela E, Robertson C, Rush K, et al., 2003, Prevalence of polycystic ovaries in women with androgenic alopecia, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 149, Pages: 439-442, ISSN: 0804-4643
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- Citations: 52
Webber LJ, Stubbs S, Stark J, et al., 2003, Formation and early development of follicles in the polycystic ovary, LANCET, Vol: 362, Pages: 1017-1021, ISSN: 0140-6736
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- Citations: 325
Franks S, 2003, Assessment and management of anovulatory infertility in polycystic ovary syndrome., Endocrinol Metab Clin North Am, Vol: 32, Pages: 639-651, ISSN: 0889-8529
PCOS is the most common cause of anovulatory infertility. Anovulation in PCOS is exacerbated by weight gain and improved by calorie restriction in overweight subjects. Fertility can usually be restored by appropriate choice of induction of ovulation, but careful monitoring is required, even when using clomiphene alone.
Iatropoulou K, Margara R, Roberts R, et al., 2003, Aneuploidy in immature human oocytes isolated from preantral follicles, 13th Genetics-Societys Mammalian Genetics and Development Workshop, Publisher: CAMBRIDGE UNIV PRESS, Pages: 229-230, ISSN: 0016-6723
Laitinen J, Taponen S, Martikainen H, et al., 2003, Body size from birth to adulthood as a predictor of self-reported polycystic ovary syndrome symptoms, INTERNATIONAL JOURNAL OF OBESITY, Vol: 27, Pages: 710-715, ISSN: 0307-0565
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- Citations: 113
Franks S, Roberts R, Hardy K, 2003, Gonadotrophin regimens and oocyte quality in women with polycystic ovaries., Reprod Biomed Online, Vol: 6, Pages: 181-184, ISSN: 1472-6483
The systemic endocrine environment during the later stages of follicle development has a crucial role in co-ordinating follicular and oocyte maturation before ovulation. Polycystic ovary syndrome (PCOS) is associated with abnormal circulating hormones, abnormal peri-follicular vascularity and significant abnormalities of granulosa cell function. After induction of ovulation, fertilization rates in vivo in women with PCOS are normal, but there is an increased risk of early pregnancy loss, particularly in obese patients. After in-vitro maturation of oocytes or following ovulation induction for IVF, oocyte and embryo quality in vitro are not obviously impaired in PCOS. In some reports however, specific endocrine abnormalities, such as hyperinsulinaemia/insulin resistance, have been noted to be associated with reduced fertilization rates and abnormal early embryonic development.
Taponen S, Martikainen H, Järvelin MR, et al., 2003, Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism:: Northern Finland birth cohort 1966 study, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 88, Pages: 141-147, ISSN: 0021-972X
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- Citations: 117
Gilling-Smith C, Franks S, 2003, Hirsutism & Virilization, In Gynaecology, Editors: Shaw, Soutter, Stanton, Edinburgh, Publisher: Churchill Livingstone, Pages: 387-399
Roberts R, Franks S, Hardy K, 2002, Culture environment modulates maturation and metabolism of human oocytes, HUMAN REPRODUCTION, Vol: 17, Pages: 2950-2956, ISSN: 0268-1161
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- Citations: 69
Sharpe RM, Franks S, 2002, Environment, lifestyle and infertility - an inter-generational issue, NATURE CELL BIOLOGY, Vol: 4, Pages: S33-S40, ISSN: 1465-7392
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- Citations: 86
Abbott DH, Dumesic DA, Franks S, 2002, Developmental origin of polycystic ovary syndrome - a hypothesis, JOURNAL OF ENDOCRINOLOGY, Vol: 174, ISSN: 0022-0795
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- Citations: 344
Haddad L, Evans JC, Gharani N, et al., 2002, Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 87, Pages: 2606-2610, ISSN: 0021-972X
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- Citations: 52
Franks S, 2002, Adult polycystic ovary syndrome begins in childhood, BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 16, Pages: 263-272, ISSN: 1521-690X
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- Citations: 81
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