Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ollila:2019:10.1210/jc.2018-00570,
author = {Ollila, M-ME and Kaikkonen, K and Järvelin, M-R and Huikuri, HV and Tapanainen, JS and Franks, S and Piltonen, TT and Morin-Papunen, L},
doi = {10.1210/jc.2018-00570},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {1221--1231},
title = {Self-reported polycystic ovary syndrome is associated with hypertension: a Northern Finland Birth Cohort 1966 Study},
url = {http://dx.doi.org/10.1210/jc.2018-00570},
volume = {104},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Context: PCOS is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension. Objective: To investigate in a population-based set-up whether PCOS associates with the risk of hypertension independently of body-mass-index (BMI), and with cardiovascular manifestations. Design: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46. Setting: General community. Participants: Women who reported both oligo/amenorrhea and hirsutism at age 31 and/or diagnosis of PCOS by age 46 (self-reported PCOS [srPCOS], n=279) and women without PCOS symptoms or diagnosis (n=1577). Intervention: None. Main Outcome Measures: Blood pressure (BP), BMI, cardiovascular manifestations. Results: Use of antihypertensive medication was significantly more common in women with srPCOS. At age 31, women with srPCOS had significantly higher systolic (SBP) and diastolic BP (DBP) than control women (SBP: normal-weight: 119.9±13.2 vs. 116.9±11.4mmHg, P=0.017; overweight/obese: 126.1±14.3 vs. 123.0±11.9mmHg, P=0.031; and DBP: normal-weight: 75.5±10.0 vs. 72.4±9.6mmHg, P=0.003; overweight/obese: 80.7±11.8 vs. 78.0±10.6mmHg, P=0.031). At age 46, srPCOS was significantly associated with hypertension (AOR=1.56 [1.14-2.13]) independently of BMI, and with higher cardiovascular morbidity (6.8% vs. 3.4%, P=0.011). Hypertensive srPCOS displayed consistent, unfavorable changes in cardiac structure and function compared with controls. Conclusion: Women with srPCOS displayed higher BP compared with controls already at early age and srPCOS was associated with hypertension independently of overweight/obesity. srPCOS was associated with increased cardiovascular morbidity in premenopausal women, suggesting that cardiovascular disease risk factors should be screened and efficiently managed early enough in women with PCOS.
AU  - Ollila,M-ME
AU  - Kaikkonen,K
AU  - Järvelin,M-R
AU  - Huikuri,HV
AU  - Tapanainen,JS
AU  - Franks,S
AU  - Piltonen,TT
AU  - Morin-Papunen,L
DO  - 10.1210/jc.2018-00570
EP  - 1231
PY  - 2019///
SN  - 0021-972X
SP  - 1221
TI  - Self-reported polycystic ovary syndrome is associated with hypertension: a Northern Finland Birth Cohort 1966 Study
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/jc.2018-00570
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30445634
UR  - https://academic.oup.com/jcem/article/104/4/1221/5183251
UR  - http://hdl.handle.net/10044/1/66376
VL  - 104
ER  -
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