Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barber:2019:10.1177/1179558119874042,
author = {Barber, TM and Hanson, P and Weickert, MO and Franks, S},
doi = {10.1177/1179558119874042},
journal = {Clinical Medicine Insights : Reproductive Health},
pages = {1179558119874042--1179558119874042},
title = {Obesity and polycystic ovary syndrome: implications for pathogenesis and novel management strategies},
url = {http://dx.doi.org/10.1177/1179558119874042},
volume = {13},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive, hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition, exacerbated by obesity. There is a close link between obesity and PCOS based on epidemiological data, and more recently corroborated through genetic studies. There are many mechanisms mediating the effects of weight-gain and obesity on the development of PCOS. The metabolic effects of insulin resistance and steroidogenic and reproductive effects of hyperinsulinaemia are important mechanisms. Adipokine production by subcutaneous and visceral fat appears to play a part in metabolic function. However, given the complexity of PCOS pathogenesis, it is important also to consider possible effects of PCOS on further weight-gain, or at least on hampering attempts at weight-loss and maintenance through lifestyle changes. Possible mediators of these effects include changes in energy expenditure, mental ill health, or physical inactivity. In this brief review, we discuss the main mechanisms that underlie the association between obesity and PCOS, from divergent perspectives of weight-gain contributing to development of PCOS and vice versa. We also consider novel management options for women with obesity and PCOS.
AU  - Barber,TM
AU  - Hanson,P
AU  - Weickert,MO
AU  - Franks,S
DO  - 10.1177/1179558119874042
EP  - 1179558119874042
PY  - 2019///
SN  - 1179-5581
SP  - 1179558119874042
TI  - Obesity and polycystic ovary syndrome: implications for pathogenesis and novel management strategies
T2  - Clinical Medicine Insights : Reproductive Health
UR  - http://dx.doi.org/10.1177/1179558119874042
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31523137
UR  - http://hdl.handle.net/10044/1/74003
VL  - 13
ER  -
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