Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Siemienowicz:2021:10.1016/j.mce.2020.111042,
author = {Siemienowicz, KJ and Coukan, F and Franks, S and Rae, MT and Duncan, WC},
doi = {10.1016/j.mce.2020.111042},
journal = {Molecular and Cellular Endocrinology},
title = {Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS)},
url = {http://dx.doi.org/10.1016/j.mce.2020.111042},
volume = {519},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to metabolic dysfunction in PCOS. We hypothesised that aberrant adipogenesis during adolescence, and downstream metabolic perturbations, contributes to the metabolic phenotype of adult PCOS. We used prenatally androgenised (PA) sheep as a clinically realistic model of PCOS. During adolescence, but not during fetal or early life of PA sheep, adipogenesis was decreased in subcutaneous adipose tissue (SAT) accompanied by decreased leptin, adiponectin, and increased FFAs. In adulthood, PA sheep developed adipocyte hypertrophy in SAT paralleled by increased expression of inflammatory markers, elevated FFAs and increased expression of genes linked to fat accumulation in visceral adipose tissue. This study provides better understanding into the pathophysiology of PCOS from puberty to adulthood and identifies opportunity for early clinical intervention to normalise adipogenesis and ameliorate the metabolic phenotype.
AU  - Siemienowicz,KJ
AU  - Coukan,F
AU  - Franks,S
AU  - Rae,MT
AU  - Duncan,WC
DO  - 10.1016/j.mce.2020.111042
PY  - 2021///
SN  - 0303-7207
TI  - Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS)
T2  - Molecular and Cellular Endocrinology
UR  - http://dx.doi.org/10.1016/j.mce.2020.111042
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33010309
UR  - http://hdl.handle.net/10044/1/84004
VL  - 519
ER  -
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