Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Barber:2021:10.1111/cen.14421,
author = {Barber, TM and Franks, S},
doi = {10.1111/cen.14421},
journal = {Clinical Endocrinology},
pages = {531--541},
title = {Obesity and polycystic ovary syndrome},
url = {http://dx.doi.org/10.1111/cen.14421},
volume = {95},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The increased global prevalence of obesity over the last 40years has driven a rise in prevalence of obesityrelated comorbidities, including polycystic ovary syndrome (PCOS). On a background of genetic susceptibility, PCOS often becomes clinically manifest following weight gain, commonly during adolescence. A common endocrinopathy affecting between 6%10% of reproductiveage women, PCOS presents with the cardinal features of hyperandrogenism, reproductive and metabolic dysfunction. PCOS associates with insulin resistance, independently of (but amplified by) obesity. Insulin resistance in PCOS is characterized by abnormal postreceptor signalling within the phosphatidylinositolkinase (PI3K) pathway. Multiple factors (including most notably, weight gain) contribute towards the severity of insulin resistance in PCOS. Compensatory hyperinsulinaemia ensues, resulting in overstimulation of the (intact) postreceptor mitogenactivated protein kinase (MAPK) insulin pathway, with consequent implications for steroidogenesis and ovarian function. In this concise review, we explore the effects of weight gain and obesity on the pathogenesis of PCOS from the perspective of its three cardinal features of hyperandrogenism, reproductive and metabolic dysfunction, with a focus on the central mediating role of the insulin pathway. We also consider key lifestyle strategies for the effective management of obese and overweight women with PCOS.
AU  - Barber,TM
AU  - Franks,S
DO  - 10.1111/cen.14421
EP  - 541
PY  - 2021///
SN  - 0300-0664
SP  - 531
TI  - Obesity and polycystic ovary syndrome
T2  - Clinical Endocrinology
UR  - http://dx.doi.org/10.1111/cen.14421
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000613188500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/cen.14421
UR  - http://hdl.handle.net/10044/1/86545
VL  - 95
ER  -
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