Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pölönen:2022:10.1530/EJE-22-0462,
author = {Pölönen, J and Pinola, P and Ronkainen, J and Blakemore, AI and Buxton, JL and Tapanainen, JS and Franks, S and Piltonen, TT and Sebert, S and Morin-Papunen, L},
doi = {10.1530/EJE-22-0462},
journal = {European Journal of Endocrinology},
pages = {651--661},
title = {Polycystic ovary syndrome and leukocyte telomere length: cross-sectional and longitudinal changes},
url = {http://dx.doi.org/10.1530/EJE-22-0462},
volume = {187},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective Telomeres are DNA-protein complexes that protect chromosome ends from DNA damage and are surrogate biomarkers of cellular ageing. Current evidence, almost entirely from cross-sectional observations, supports negative associations between leukocyte telomere length (LTL) and adverse lifestyle factors and cardio-metabolic risk factors. Polycystic ovary syndrome (PCOS), the most common gynecological endocrine disorder, is associated with inflammation and oxidative stress, both factors associated with accelerated telomere attrition. We therefore hypothesized that LTL would be shorter and decrease more rapidly in women with PCOS in comparison to a control population. Design Population-based cohort study: women of Northern Finland Birth Cohort 1966, with clinical examinations at ages 31 and 46. The sample included self-reported PCOS (PCOS) (age 31:N=190; age 46:N=207) and referent women (age 31:N=1054; age 46:N=1324) with data on LTL. Methods The association between LTL and PCOS at ages 31 and 46 was analyzed by linear regression models adjusted for BMI, smoking, alcohol consumption and socioeconomic status at the corresponding age. Results Women with PCOS had similar mean LTL at ages 31 and 46 (P>0.4 for both). The mean LTL change between ages 31 and 46 did not differ between groups (P=0.19). However, we observed a significant LTL attrition between ages 31 and 46 in the reference population (P<0.001), but not in women with PCOS (P=0.96). Conclusions This finding may suggest a difference in LTL attrition rate in women with PCOS, an unexpected finding that might affect their risk of age-related disease. Further research is needed to clarify the underlying mechanisms.
AU  - Pölönen,J
AU  - Pinola,P
AU  - Ronkainen,J
AU  - Blakemore,AI
AU  - Buxton,JL
AU  - Tapanainen,JS
AU  - Franks,S
AU  - Piltonen,TT
AU  - Sebert,S
AU  - Morin-Papunen,L
DO  - 10.1530/EJE-22-0462
EP  - 661
PY  - 2022///
SN  - 0804-4643
SP  - 651
TI  - Polycystic ovary syndrome and leukocyte telomere length: cross-sectional and longitudinal changes
T2  - European Journal of Endocrinology
UR  - http://dx.doi.org/10.1530/EJE-22-0462
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36074951
UR  - https://eje.bioscientifica.com/view/journals/eje/187/5/EJE-22-0462.xml
UR  - http://hdl.handle.net/10044/1/99807
VL  - 187
ER  -
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