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@article{Surendran:2016:10.1038/ng.3654,
author = {Surendran, P and Drenos, F and Young, R and Warren, H and Cook, JP and Manning, AK and Grarup, N and Sim, X and Barnes, DR and Witkowska, K and Staley, JR and Tragante, V and Tukiainen, T and Yaghootkar, H and Masca, N and Freitag, DF and Ferreira, T and Giannakopoulou, O and Tinker, A and Harakalova, M and Mihailov, E and Liu, C and Kraja, AT and Nielsen, SF and Rasheed, A and Samuel, M and Zhao, W and Bonnycastle, LL and Jackson, AU and Narisu, N and Swift, AJ and Southam, L and Marten, J and Huyghe, JR and Stanáková, A and Fava, C and Ohlsson, T and Matchan, A and Stirrups, KE and Bork-Jensen, J and Gjesing, AP and Kontto, J and Perola, M and Shaw-Hawkins, S and Havulinna, AS and Zhang, H and Donnelly, LA and Groves, CJ and Rayner, NW and Neville, MJ and Robertson, NR and Yiorkas, AM and Herzig, KH and Kajantie, E and Zhang, W and Willems, SM and Lannfelt, L and Malerba, G and Soranzo, N and Trabetti, E and Verweij, N and Evangelou, E and Moayyeri, A and Vergnaud, AC and Nelson, CP },
doi = {10.1038/ng.3654},
journal = {Nature Genetics},
pages = {1151--1161},
title = {Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension},
url = {http://dx.doi.org/10.1038/ng.3654},
volume = {48},
year = {2016}
}

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TY  - JOUR
AB  - High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
AU  - Surendran,P
AU  - Drenos,F
AU  - Young,R
AU  - Warren,H
AU  - Cook,JP
AU  - Manning,AK
AU  - Grarup,N
AU  - Sim,X
AU  - Barnes,DR
AU  - Witkowska,K
AU  - Staley,JR
AU  - Tragante,V
AU  - Tukiainen,T
AU  - Yaghootkar,H
AU  - Masca,N
AU  - Freitag,DF
AU  - Ferreira,T
AU  - Giannakopoulou,O
AU  - Tinker,A
AU  - Harakalova,M
AU  - Mihailov,E
AU  - Liu,C
AU  - Kraja,AT
AU  - Nielsen,SF
AU  - Rasheed,A
AU  - Samuel,M
AU  - Zhao,W
AU  - Bonnycastle,LL
AU  - Jackson,AU
AU  - Narisu,N
AU  - Swift,AJ
AU  - Southam,L
AU  - Marten,J
AU  - Huyghe,JR
AU  - Stanáková,A
AU  - Fava,C
AU  - Ohlsson,T
AU  - Matchan,A
AU  - Stirrups,KE
AU  - Bork-Jensen,J
AU  - Gjesing,AP
AU  - Kontto,J
AU  - Perola,M
AU  - Shaw-Hawkins,S
AU  - Havulinna,AS
AU  - Zhang,H
AU  - Donnelly,LA
AU  - Groves,CJ
AU  - Rayner,NW
AU  - Neville,MJ
AU  - Robertson,NR
AU  - Yiorkas,AM
AU  - Herzig,KH
AU  - Kajantie,E
AU  - Zhang,W
AU  - Willems,SM
AU  - Lannfelt,L
AU  - Malerba,G
AU  - Soranzo,N
AU  - Trabetti,E
AU  - Verweij,N
AU  - Evangelou,E
AU  - Moayyeri,A
AU  - Vergnaud,AC
AU  - Nelson,CP
AU  - Poveda,A
AU  - Varga,TV
AU  - Caslake,M
AU  - de,Craen AJ
AU  - Trompet,S
AU  - Luan,J
AU  - Scott,RA
AU  - Harris,SE
AU  - Liewald,DC
AU  - Marioni,R
AU  - Menni,C
AU  - Farmaki,AE
AU  - Hallmans,G
AU  - Renström,F
AU  - Huffman,JE
AU  - Hassinen,M
AU  - Burgess,S
AU  - Vasan,RS
AU  - Felix,JF
AU  - CHARGE-Heart,Failure Consortium
AU  - Uria-Nickelsen,M
AU  - Malarstig,A
AU  - Reilly,DF
AU  - Hoek,M
AU  - Vogt,TF
AU  - Lin,H
AU  - Lieb,W
AU  - EchoGen,Consortium
AU  - Traylor,M
AU  - Markus,HS
AU  - METASTROKE,Consortium
AU  - Highland,HM
AU  - Justice,AE
AU  - Marouli,E
AU  - GIANT,Consortium
AU  - Lindström,J
AU  - Uusitupa,M
AU  - Komulainen,P
AU  - Lakka,TA
AU  - Rauramaa,R
AU  - Polasek,O
AU  - Rudan,I
AU  - Rolandsson,O
AU  - Franks,PW
AU  - Dedoussis,G
AU  - Spector,TD
AU  - EPIC-InterAct,Consortium
AU  - Jousilahti,P
AU  - Männistö,S
AU  - Deary,IJ
AU  - Starr,JM
AU  - Langenberg,C
AU  - Wareham,NJ
AU  - Brown,MJ
AU  - Dominiczak,AF
AU  - Connell,JM
AU  - Jukema,JW
AU  - Sattar,N
AU  - Ford,I
AU  - Packard,CJ
AU  - Esko,T
AU  - Mägi,R
AU  - Metspalu,A
AU  - de,Boer RA
AU  - van,der Meer P
AU  - van,der Harst P
AU  - Lifelines,Cohort Study
AU  - Gambaro,G
AU  - Ingelsson,E
AU  - Lind,L
AU  - de,Bakker PI
AU  - Numans,ME
AU  - Brandslund,I
AU  - Christensen,C
AU  - Petersen,ER
AU  - Korpi-Hyövälti,E
AU  - Oksa,H
AU  - Chambers,JC
AU  - Kooner,JS
AU  - Blakemore,AI
AU  - Franks,S
AU  - Jarvelin,MR
AU  - Husemoen,LL
AU  - Linneberg,A
AU  - Skaaby,T
AU  - Thuesen,B
AU  - Karpe,F
AU  - Tuomilehto,J
AU  - Doney,AS
AU  - Morris,AD
AU  - Palmer,CN
AU  - Holmen,OL
AU  - Hveem,K
AU  - Willer,CJ
AU  - Tuomi,T
AU  - Groop,L
AU  - Käräjämäki,A
AU  - Palotie,A
AU  - Ripatti,S
AU  - Salomaa,V
AU  - Alam,DS
AU  - Majumder,AA
AU  - Di,Ang
DO  - 10.1038/ng.3654
EP  - 1161
PY  - 2016///
SN  - 1546-1718
SP  - 1151
TI  - Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3654
UR  - http://hdl.handle.net/10044/1/40215
VL  - 48
ER  -

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