Imperial College London
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Emeritus ProfessorStephenFranks

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2109s.franks Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 4217

 
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Location

 

5009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Couto:2017:10.1038/ijo.2017.126,
author = {Couto, Alves A and Valcarcel, B and Makinen, V and Morin-Papunen, L and Sebert, S and Kangas, AJ and Sioninen, P and Das, S and De, Iorio M and Coin, L and Ala-Korpela, M and Jarvelin, MR and Franks, S},
doi = {10.1038/ijo.2017.126},
journal = {International Journal of Obesity},
pages = {1331--1340},
title = {Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity},
url = {http://dx.doi.org/10.1038/ijo.2017.126},
volume = {41},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance, and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels.Design and Methods: We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3,127). Subjects were 31 years old at examination. The main analyses were adjusted for waist circumference (WC) as a proxy measure of central obesity. Subsequently, metabolite concentrations were compared between cases and controls within pre-defined WC strata. On each stratum, additional metabolomics association analyses with testosterone levels were conducted separately among cases and controls.Results: Overall, women with PCOS showed more adverse metabolite profiles than the controls. Four lipid fractions in different subclasses of very low density lipoprotein (VLDL) were associated with PCOS, after adjusting for WC and correction for multiple testing (P<0.002). In stratified analysis the PCOS women within large WC strata (≥98 cm) had significantly lower high density lipoprotein (HDL) levels, ApoA1 and albumin values compared to the controls. Testosterone levels were significantly associated with VLDL and serum lipids in PCOS cases with large WC but not in the controls. The higher testosterone levels, adjusted for WC, adversely associated with insulin levels and HOMA IR in cases but not in the controls.Conclusions: Our findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long term health of women with PCOS.
AU  - Couto,Alves A
AU  - Valcarcel,B
AU  - Makinen,V
AU  - Morin-Papunen,L
AU  - Sebert,S
AU  - Kangas,AJ
AU  - Sioninen,P
AU  - Das,S
AU  - De,Iorio M
AU  - Coin,L
AU  - Ala-Korpela,M
AU  - Jarvelin,MR
AU  - Franks,S
DO  - 10.1038/ijo.2017.126
EP  - 1340
PY  - 2017///
SN  - 1476-5497
SP  - 1331
TI  - Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity
T2  - International Journal of Obesity
UR  - http://dx.doi.org/10.1038/ijo.2017.126
UR  - http://hdl.handle.net/10044/1/47983
VL  - 41
ER  -
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