Professor Steve Gentleman

Faculty of Medicine, Department of Brain Sciences

Professor of Neuropathology

Contact

Location

E407Burlington DanesHammersmith Campus

Summary

Steve Gentleman is Professor of Neuropathology in the Department of Medicine at Imperial College London. Over the past 20 years he has run an active research team investigating the pathology of neurodegenerative disease and traumatic brain injury. In some of his early work he identified pathological changes in the brains of people who had died of a serious head injury which were very similar to those seen in the early stages of Alzheimer’s disease.This link, based on inflammatory mechanisms, is still the focus of research for his research team in collaboration with colleagues throughout the UK and USA. He also discovered that damage to the processes of nerve cells as a result of head injury was far more common than originally thought. In more recent years he has been part of a European consortium of neuropathologists who have been working to standardise the diagnosis of neurodegenerative diseases. Using this expertise he provides diagnostic support for the Parkinson’s UK and Multiple Sclerosis Society Tissue Banks at Imperial and is a member of the Medical Research Council Brain Bank Network management committee.

In addition to his research interests Steve has key teaching roles in the faculty of Medicine. He is the leader for the Life Cycle and Regulatory Systems theme and the course leader for a number of subjects including neuroscience, head and neck anatomy and aspects of the Neuroscience BSc. In addition he is the Director of Education for the Department of Medicine.

Current funding

National Institute on Aging (US)
UK Multiple Sclerosis Society
Parkinson's UK
Alzheimer Society/BUPA

Key research areas

Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, neurodegeneration, inflammation, brain banking

Publications

Journals

Reho P, Saez-Atienzar S, Ruffo P, et al.Reho P, Saez-Atienzar S, Ruffo P, Solaiman S, Shah Z, Chia R, Kaivola K, Traynor BJ, Tilley BS, Gentleman SM, Hodges AK, Aarsland D, Monuki ES, Newell KL, Woltjer R, Albert MS, Dawson TM, Rosenthal LS, Troncoso JC, Pletnikova O, Serrano GE, Beach TG, Easwaran HP, Scholz SW close, 2024, Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies., Commun Biol, Vol:7

Gentleman SM, Liu AKL, 2024, Neuropathological Assessment as an Endpoint in Clinical Trial Design., Methods Mol Biol, Vol:2785, Pages:261-270

Tsalenchuk M, Gentleman S, Marzi S, 2023, Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease, Npj Parkinson's Disease, Vol:9, ISSN:2373-8057, Pages:1-12

Kaivola K, Chia R, Ding J, et al.Kaivola K, Chia R, Ding J, Rasheed M, Fujita M, Menon V, Walton RL, Collins RL, Billingsley K, Brand H, Talkowski M, Zhao X, Dewan R, Stark A, Ray A, Solaiman S, Alvarez Jerez P, Malik L, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Masellis M, Keith J, Black SE, Ferrucci L, Resnick SM, Tanaka T, American Genome Center, International LBD Genomics Consortium, International ALS/FTD Consortium, PROSPECT Consortium, Topol E, Torkamani A, Tienari P, Foroud TM, Ghetti B, Landers JE, Ryten M, Morris HR, Hardy JA, Mazzini L, D'Alfonso S, Moglia C, Calvo A, Serrano GE, Beach TG, Ferman T, Graff-Radford NR, Boeve BF, Wszolek ZK, Dickson DW, Chiò A, Bennett DA, De Jager PL, Ross OA, Dalgard CL, Gibbs JR, Traynor BJ, Scholz SW close, 2023, Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias., Cell Genom, Vol:3

Tauber CV, Schwarz SC, Roesler TW, et al.Tauber CV, Schwarz SC, Roesler TW, Arzberger T, Gentleman S, Windl O, Krumbiegel M, Reis A, Ruf VC, Herms J, Hoeglinger GU close, 2023, Different <i>MAPT</i> haplotypes influence expression of <i>total MAPT</i> in postmortem brain tissue, Acta Neuropathologica Communications, Vol:11, ISSN:2051-5960

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