Imperial College London

Professor Steve Gentleman

Faculty of MedicineDepartment of Brain Sciences

Professor of Neuropathology



+44 (0)20 7594 6586s.gentleman Website




E407Burlington DanesHammersmith Campus





Steve Gentleman is Professor of Neuropathology in the Department of Medicine at Imperial College London. Over the past 20 years he has run an active research team investigating the pathology of neurodegenerative disease and traumatic brain injury. In some of his early work he identified pathological changes in the brains of people who had died of a serious head injury which were very similar to those seen in the early stages of Alzheimer’s disease.This link, based on inflammatory mechanisms, is still the focus of research for his research team in collaboration with colleagues throughout the UK and USA. He also discovered that damage to the processes of nerve cells as a result of head injury was far more common than originally thought. In more recent years he has been part of a European consortium of neuropathologists who have been working to standardise the diagnosis of neurodegenerative diseases. Using this expertise he provides diagnostic support for the Parkinson’s UK and Multiple Sclerosis Society Tissue Banks at Imperial and is a member of the Medical Research Council Brain Bank Network management committee.

In addition to his research interests Steve has key teaching roles in the faculty of Medicine. He is the leader for the Life Cycle and Regulatory Systems theme and the course leader for a number of subjects including neuroscience, head and neck anatomy and aspects of the Neuroscience BSc. In addition he is the Director of Education for the Department of Medicine.

Current funding

  • National Institute on Aging (US)
  • UK Multiple Sclerosis Society
  • Parkinson's UK
  • Alzheimer Society/BUPA

Key research areas

Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, neurodegeneration, inflammation, brain banking



Reho P, Saez-Atienzar S, Ruffo P, et al., 2024, Differential methylation analysis in neuropathologically confirmed dementia with Lewy bodies., Commun Biol, Vol:7

Gentleman SM, Liu AKL, 2024, Neuropathological Assessment as an Endpoint in Clinical Trial Design., Methods Mol Biol, Vol:2785, Pages:261-270

Tsalenchuk M, Gentleman S, Marzi S, 2023, Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease, Npj Parkinson's Disease, Vol:9, ISSN:2373-8057, Pages:1-12

Kaivola K, Chia R, Ding J, et al., 2023, Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias., Cell Genom, Vol:3

Tauber CV, Schwarz SC, Roesler TW, et al., 2023, Different <i>MAPT</i> haplotypes influence expression of <i>total MAPT</i> in postmortem brain tissue, Acta Neuropathologica Communications, Vol:11, ISSN:2051-5960

More Publications