Publications
313 results found
Wan Y, Xu J, Meng F, et al., 2010, Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice, CRITICAL CARE MEDICINE, Vol: 38, Pages: 2190-2198, ISSN: 0090-3493
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- Citations: 124
Kalaitzakis ME, Walls AJ, Pearce RK, et al., 2010, Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other Parkinsonian syndromes., Neurobiol Dis.
Pey P, Kalaitzakis ME, Sue G, et al., 2010, CD163: a marker of alternative microglial activation in Alzheimer's disease, 17th International Congress of Neuropathology (ICN 2010), Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 22-22, ISSN: 1015-6305
Kalaitzakis ME, Gentleman SM, Pearce RKB, 2010, Pathological Correlates of Visual Hallucinations in Parkinson's disease, 17th International Congress of Neuropathology (ICN 2010), Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 28-28, ISSN: 1015-6305
Gentleman SM, 2010, Neuropathology, Psychiatry. An evidence-based text, Editors: Puri, Treasaden, Publisher: Hodder Arnold, Pages: 435-444, ISBN: 978 034 0950050
Sastre M, Gentleman S, 2010, NSAIDs: How they work and their prospects as therapeutics in Alzheimer’s disease., Frontiers in Ageing Neuroscience, Vol: 2
Watts HR, Anderson PJ, Ma D, et al., 2010, Differential effects of amyloid-beta peptide aggregation status on in vivo retinal neurotoxicity., Eye and Brain., Vol: 2, Pages: 121-137
Kalaitzakis ME, Gentleman SM, Walls AJ, et al., 2010, Striatal amyloid-β pathology and dementia in Lewy body and related disorders, 14th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S319-S320, ISSN: 0885-3185
Kalaitzakis ME, Pearce RKB, Gentleman SM, 2009, Clinical correlates of pathology in the claustrum in Parkinson's disease and dementia with Lewy bodies, NEUROSCIENCE LETTERS, Vol: 461, Pages: 12-15, ISSN: 0304-3940
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- Citations: 32
Kalaitzakis ME, Graeber MB, Gentleman SM, et al., 2009, Parkinson Disease: Extranigral, Multisystem, and α-Synuclein "Plus", ARCHIVES OF NEUROLOGY, Vol: 66, Pages: 914-915, ISSN: 0003-9942
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- Citations: 6
Alafuzoff I, Ince PG, Arzberger T, et al., 2009, Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium, ACTA NEUROPATHOLOGICA, Vol: 117, Pages: 635-652, ISSN: 0001-6322
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- Citations: 203
Alafuzoff I, Al-Sarraj S, Arzberger T, et al., 2009, Reproducibility in the Assessment of Alzheimer's Disease and Lewy Body Disease-Related Pathologies: A Study by Brain Net Euro, 85th Annual Meeting of the American-Association-of-Neuropathologists, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 556-556, ISSN: 0022-3069
Alafuzoff I, Thal DR, Arzberger T, et al., 2009, Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium, ACTA NEUROPATHOLOGICA, Vol: 117, Pages: 309-320, ISSN: 0001-6322
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- Citations: 126
Kalaitzakis ME, Christian LM, Moran LB, et al., 2009, Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease, PARKINSONISM & RELATED DISORDERS, Vol: 15, Pages: 196-204, ISSN: 1353-8020
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- Citations: 100
Aruoma OI, Jen SSM, Watts HR, et al., 2009, Acute and chronic effects of intravitreally injected β-amyloid on the neurotransmitter system in the retina, TOXICOLOGY, Vol: 256, Pages: 92-100, ISSN: 0300-483X
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- Citations: 8
Kalaitzakis ME, Graeber MB, Gentleman SM, et al., 2009, Evidence against a reliable staging system of α-synuclein pathology in Parkinson's disease, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 35, Pages: 125-126, ISSN: 0305-1846
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- Citations: 13
Normahani P, Kalaitzakis ME, Pearce RKB, et al., 2009, Distribution of α-synuclein pathology in the spinal cord of Parkinson's disease patients, 110th Annual Meeting of the British-Neuropathological-Society, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 26-27, ISSN: 0305-1846
Shao E, Christian L, Kalaitzakis ME, et al., 2009, Cerebellar microglial activation in tremor dominant and akinetic-rigid Parkinson's disease, 110th Annual Meeting of the British-Neuropathological-Society, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 26-26, ISSN: 0305-1846
Alafuzoff I, Al-Sarraj S, Arzberger T, et al., 2009, Reproducibility in the assessment of Alzheimer's disease and Lewy body disease-related pathologies: a study by Brain Net Europe, 110th Annual Meeting of the British-Neuropathological-Society, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 12-13, ISSN: 0305-1846
Kalaitzakis ME, Gentleman SM, Pearce RKB, 2009, Pathological correlates of sleep disturbances in Parkinson's disease, 13th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S392-S392, ISSN: 0885-3185
Kalaitzakis ME, Gentleman SM, Pearce RKB, 2009, α-synuclein pathology in the claustrum is associated with dementia in Parkinson's disease, 13th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S301-S301, ISSN: 0885-3185
Anderson PJB, Watts HR, Jen S, et al., 2009, Differential effects of interleukin-1beta and S100B on amyloid precursor protein in rat retinal neurons., Clin Ophthalmol, Vol: 3, Pages: 235-242, ISSN: 1177-5467
PURPOSE: Interleukin-1beta (IL-1beta) and S100B calcium binding protein B (S100B) have been implicated in the pathogenesis of Alzheimer's disease. Both are present in and around senile plaques and have been shown to increase levels of amyloid precursor protein (APP) mRNA in vitro. However, it is not known how either of these substances affects APP in vivo. METHODS: We have studied the effects of IL-1beta and S100B on the expression and processing of APP using a retinal-vitreal model. We have also investigated the effect of amyloid beta peptide (Abeta) on APP in the same system and the regulation of S100B production by Abeta and IL-1beta from retinal glial cells. RESULTS: Retinal ganglion cells constitutively express APP. However, after intravitreal injection of IL-1beta or Abeta there was a marked reduction in APP levels as detected by Western blotting and IL-1beta produced a decrease in APP immunoreactivity (IR). Nissl staining showed that the integrity of the injected retinas was unchanged after injection. Two days after S100B injection, there was a small reduction in APP-IR but this was accompanied by the appearance of some intensely stained large ganglion cells and there was some up-regulation in APP holoprotein levels on Western blot. Seven days post-S100B injection, these large, highly stained cells had increased in number throughout the retina. Injection of Abeta and IL-1beta also caused an increase in S100B production within the retinal Müller glial cells. CONCLUSION: These results support the hypothesis that S100B (a glial-derived neurotrophic factor) and IL-1beta (a pro-inflammatory cytokine) can modulate the expression and processing of APP in vivo and so may contribute to the progression of Alzheimer's disease.
McGuinness L, Vontell RT, Dexter DT, et al., 2008, Optimisation of immunohistochemistry for visualising abnormal protein deposition in neurodegenerative disorders, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1726-1726, ISSN: 0300-9564
Gveric D, Nicholas R, Roncaroli F, et al., 2008, The UK multiple sclerosis tissue bank: target validation made easy, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1731-1731, ISSN: 0300-9564
Goldring K, McGuinness L, Vontell RT, et al., 2008, Clinicopathological classification of the first 100 cases donated to the UK PDS Tissue Bank at Imperial College, BrainNet Europe 2nd International Conference on Human Brain Tissue Research, Publisher: SPRINGER WIEN, Pages: 1724-1724, ISSN: 0300-9564
Gveric D, Nicholas R, Roncaroli F, et al., 2008, The UK Multiple Sclerosis Tissue Bank: resource for research, 13th Annual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/24th Congress of the European-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis/5th Congress of the Latin-Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis, Publisher: SAGE PUBLICATIONS LTD, Pages: S272-S272, ISSN: 1352-4585
Kalaitzakis ME, Graeber MB, Gentleman SM, et al., 2008, Controversies over the staging of α-synuclein pathology in Parkinson's disease, ACTA NEUROPATHOLOGICA, Vol: 116, Pages: 125-128, ISSN: 0001-6322
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- Citations: 51
Sastre M, Walter J, Gentleman SM, 2008, Interactions between APP secretases and inflammatory mediators, JOURNAL OF NEUROINFLAMMATION, Vol: 5, ISSN: 1742-2094
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- Citations: 146
Kalaitzakis ME, Graeber MB, Gentleman SM, et al., 2008, The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease:: a critical analysis of α-synuclein staging, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 34, Pages: 284-295, ISSN: 0305-1846
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- Citations: 163
Bell JE, Alafuzoff I, Al-Sarraj S, et al., 2008, Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium, ACTA NEUROPATHOLOGICA, Vol: 115, Pages: 497-507, ISSN: 0001-6322
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- Citations: 86
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