Publications

BibTex format

@article{Attems:2021:10.1007/s00401-020-02255-2,
author = {Attems, J and Toledo, JB and Walker, L and Gelpi, E and Gentleman, S and Halliday, G and Hortobagyi, T and Jellinger, K and Kovacs, GG and Lee, EB and Love, S and McAleese, KE and Nelson, PT and Neumann, M and Parkkinen, L and Polvikoski, T and Sikorska, B and Smith, C and Grinberg, LT and Thal, DR and Trojanowski, JQ and McKeith, IG},
doi = {10.1007/s00401-020-02255-2},
journal = {Acta Neuropathologica},
pages = {159--172},
title = {Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study},
url = {http://dx.doi.org/10.1007/s00401-020-02255-2},
volume = {141},
year = {2021}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues (McKeith), the modified McKeith system by Leverenz and colleagues (Leverenz), and the Unified Staging System by Beach and colleagues (Beach). All of these systems use semi-quantitative scoring (4- or 5-tier scales) of Lewy pathology (LP; i.e., Lewy bodies and Lewy neurites) in defined cortical and subcortical areas. While these systems are widely used, some suffer from low inter-rater reliability and/or an inability to unequivocally classify all cases with LP. To address these limitations, we devised a new system, the LP consensus criteria (LPC), which is based on the McKeith system, but applies a dichotomous approach for the scoring of LP (i.e., “absent” vs. “present”) and includes amygdala-predominant and olfactory-only stages. α-Synuclein-stained slides from brainstem, limbic system, neocortex, and olfactory bulb from a total of 34 cases with LP provided by the Newcastle Brain Tissue Resource (NBTR) and the University of Pennsylvania brain bank (UPBB) were scanned and assessed by 16 raters, who provided diagnostic categories for each case according to Braak, McKeith, Leverenz, Beach, and LPC systems. In addition, using LP scores available from neuropathological reports of LP cases from UPBB (n = 202) and NBTR (n = 134), JT (UPBB) and JA (NBTR) assigned categories according to all staging systems to these cases. McKeith, Leverenz, and LPC systems reached good (Krippendorff’s α ≈ 0.6), while both Braak and Beach systems had lower (Krippendorff’s α ≈ 0.4) inter-rater reliability, respectively. Using the LPC system, all cases could be unequivocally classified by the majority of raters, which was also seen for 97.1% when the Beach system was used. However, a
AU  - Attems,J
AU  - Toledo,JB
AU  - Walker,L
AU  - Gelpi,E
AU  - Gentleman,S
AU  - Halliday,G
AU  - Hortobagyi,T
AU  - Jellinger,K
AU  - Kovacs,GG
AU  - Lee,EB
AU  - Love,S
AU  - McAleese,KE
AU  - Nelson,PT
AU  - Neumann,M
AU  - Parkkinen,L
AU  - Polvikoski,T
AU  - Sikorska,B
AU  - Smith,C
AU  - Grinberg,LT
AU  - Thal,DR
AU  - Trojanowski,JQ
AU  - McKeith,IG
DO  - 10.1007/s00401-020-02255-2
EP  - 172
PY  - 2021///
SN  - 0001-6322
SP  - 159
TI  - Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study
T2  - Acta Neuropathologica
UR  - http://dx.doi.org/10.1007/s00401-020-02255-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000605104600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/86310
VL  - 141
ER  -

Download

Professor Steve Gentleman

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)