Imperial College London
Alternate

DrSarahGerver

Faculty of Medicine, Department of Infectious Disease

Honorary Lecturer
 
 
 
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Contact

 

s.gerver Website

 
 
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Location

 

Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Gerver:2011,
author = {Gerver, SM and Xu, F and Tian, L and Griffin, J and Garnett, GP and Markowitz, LE and Hallett, TB},
title = {Incidence Rate of Herpes Simplex Virus type 2 (HSV-2) in the US, 1988-2008},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Background: HSV-2 infection remains a major public health problem in the US, where the prevalence is 16.2% in persons aged 14-49. In this report, we provide national estimates of new HSV-2 infections in the US and examine trends in incidence over the past two decades.Methods: A simple catalytic model was used to estimate HSV-2 force of infection (FOI), defined as the incidence of HSV-2 in the susceptible population, from National Health and Nutrition Examination Surveys (NHANES) in the US from 1988 through 2008.  HSV-2 serology was included in the nationally representative surveys during 1988-1994 (NHANES III) and in continuous NHANES from 1999-2008. Incidence rates and trends over time were estimated by age, sex and race/ethnic group for non-Hispanic whites, non-Hispanic blacks, and Mexican-Americans.Results: HSV-2 FOI rates were highest in non-Hispanic blacks and lowest in non-Hispanic whites, with the FOI among 25 year old non-Hispanic black women more than 13 times greater than white men of the same age.  Rates were highest between ages 25-35 years for all sex-race/ethnicity groups (peak in non-Hispanic white and black women aged 25 years, in non-Hispanic white and black men aged 35 years and in Mexican-American women in their early-thirties) except for Mexican-American men, for whom there was less variation in FOI by age. Over the last twenty years, age-adjusted FOI rates were stable for the sex-race/ethnicity groups examined except for non-Hispanic white and Mexican-American women, in which there were decreases after 2002 and 2001, respectively.  FOI rates were lower in men than women among non-Hispanic blacks and Mexican-Americans, and in non-Hispanic whites prior to 2002. Overall, the estimated number of new HSV-2 infections in 2007-2008, among these three groups, aged 14-49 years, was in excess of 750,000, with 48% (~360,000) occurring in women and 52% (~392,000) in men.  Nearly half (45%) of all infections occurred in persons under 25 years old (34% and 57
AU  - Gerver,SM
AU  - Xu,F
AU  - Tian,L
AU  - Griffin,J
AU  - Garnett,GP
AU  - Markowitz,LE
AU  - Hallett,TB
PY  - 2011///
TI  - Incidence Rate of Herpes Simplex Virus type 2 (HSV-2) in the US, 1988-2008
ER  -
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