Summary
The main focus of the research group is in translational research in gynaecological cancers. In particular biomarker discovery and development (specifically immunological markers) in ovarian and endometrial cancers. The biomarkers are now in the process of being tested for diagnosis and surgical prognosis. The concept of predicting surgical outcome in ovarian cancer is a step in developing personalised medicine and providing patients with best care possible.
Recent advances in oncolgy have improved survival in patients with cancer but research into surgery may have additional benefits for the patient. Clinical research into optimal treatment of cervival preinvasive lesions has been a focus. We have shown that clear margins of resection has a significant effect on reducing risk of recurrence from preinvasive disease.
Publications
Journals
Aboagye E, Lu H, Lou H, et al., 2023, Tumour and local lymphoid tissue interaction determines prognosis in high grade serous ovarian cancer, Cell Reports Medicine, Vol:4, ISSN:2666-3791, Pages:1-24
Li X, Marcus D, Russell J, et al., 2023, An integrated clinical-MR radiomics model to estimate survival time in patients with endometrial cancer, Journal of Magnetic Resonance Imaging, Vol:57, ISSN:1053-1807, Pages:1922-1933
Li X, Aboagye E, Michele D, et al., 2023, Prediction of deep myometrial infiltration, clinical risk category, histological type, and lymphovascular space invasion in women with endometrial cancer based on clinical and T2-weighted MRI radiomic features, Cancers, Vol:15, ISSN:2072-6694
Dannhorn A, Doria ML, McKenzie J, et al., 2023, Targeted Desorption Electrospray Ionization Mass Spectrometry Imaging for Drug Distribution, Toxicity, and Tissue Classification Studies, Metabolites, Vol:13
Oxley S, Kalra A, Sideris M, et al., 2023, Impact of Multiple COVID-19 Waves on Gynaecological Cancer Services in the UK, Cancers, Vol:15