Publications
205 results found
Chatterjee J, Farthing A, Joglekar-Pai P, et al., 2012, Total laparoscopic hysterectomy for early stage endometrial cancer in obese and morbidly obese women., Journal of Obstetrics and Gynaecology, Vol: 32, Pages: 580-584
Naji O, Abdallah Y, de Vaate AJB, et al., 2012, Standardized Approach for Imaging and Measuring Cesarean Section Scars Using Ultrasonography EDITORIAL COMMENT, OBSTETRICAL & GYNECOLOGICAL SURVEY, Vol: 67, Pages: 404-405, ISSN: 0029-7828
Chatterjee J, Haslinda Abdul Aziz N, Maine C, et al., 2012, Role of PD-L1 in In-vitro Interaction Between T-cells and Ovarian Tumour Cells, 22nd.Biennial Conference of European Association for Cancer Research, ISSN: 0959-8049
Stavraka C, MacLaran K, Gabra H, et al., 2012, A study to evaluate the cause of bone demineralisation in gynaecological cancer survivors.
Saso S, Rao C, Ashrafian H, et al., 2012, Positive pre-resection pleural lavage cytology is associated with increased risk of lung cancer recurrence in patients undergoing surgical resection: a meta-analysis of 4450 patients, THORAX, Vol: 67, Pages: 526-532, ISSN: 0040-6376
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- Citations: 14
Kyrgiou M, Stasinou SM, Arbyn M, et al., 2012, Management of low-grade squamous intra-epithelial lesions of the uterine cervix: Repeat cytology versus immediate referral to colposcopy, Cochrane Database of Systematic Reviews, Vol: 2012
This is the protocol for a review and there is no abstract. The objectives are as follows: The aim of this review will be to assess whether women with low-grade squamous intra-epithelial lesions (LSILs) should be referred immediately to colposcopy or have repeat cytology.
Van Calster B, Timmerman D, Valentin L, et al., 2012, Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol., BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 119, Pages: 662-671, ISSN: 1470-0328
Objective To compare guidelines from the Royal College of Obstetricians and Gynaecologists (RCOG) based on the Risk of Malignancy Index (RMI) with a protocol based on logistic regression model LR2 developed by the International Ovarian Tumour Analysis (IOTA) group for triaging women with an ovarian mass as low, moderate, or high risk of malignancy. Design and setting Observational diagnostic study conducted between 2005 and 2007 at 21 oncology referral centres, referral centres for ultrasonography and general hospitals. Sample In all, 1938 women undergoing surgery for an ovarian mass. Methods RCOG guidelines use the RMI to triage women as low (RMI < 25), moderate (25-250), or high (above > 250) risk. The IOTA protocol uses LR2s estimated probability of malignancy (< 0.05 indicates low risk, 0.05 but < 0.25 moderate risk, and 0.25 high risk). Main outcome measure Percentages of benign, borderline and invasive tumours classified as low, moderate or high risk. Results The IOTA and RCOG protocols classified 71.1% and 62.1% of benign tumours as low risk, respectively (difference 9.0; 95% CI 6.2-11.9, P < 0.0001). Of invasive tumours, 88.6% and 73.6% were labelled high risk (difference 15.0; 10.6-19.4, P < 0.0001), and 3.0% and 5.2% were labelled low risk (difference) 2.2;) 4.6 to 0.2, P = 0.07) respectively by each protocol. Similar results were found after stratification for menopausal status. Conclusions The IOTA protocol was more accurate for triage than the RCOG protocol. The IOTA protocol would avoid major surgery for more women with benign tumours while still appropriately referring more women with an invasive tumour to a gynaecological oncologist.
Clancy NT, Sauvage V, Saso S, et al., 2012, Registration and analysis of multispectral images acquired during uterine transplantation surgery, OSA Biomed
Stavraka C, Ford A, Ghaem-Maghami S, et al., 2012, A study of symptoms described by ovarian cancer survivors, GYNECOLOGIC ONCOLOGY, Vol: 125, Pages: 59-64, ISSN: 0090-8258
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- Citations: 54
Naji O, Abdallah Y, De Vaate AJB, et al., 2012, Standardized approach for imaging and measuring Cesarean section scars using ultrasonography, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 39, Pages: 252-259, ISSN: 0960-7692
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- Citations: 98
Rahman NA, Bennink HJTC, Chrusciel M, et al., 2012, A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3, FASEB JOURNAL, Vol: 26, Pages: 324-333, ISSN: 0892-6638
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- Citations: 8
Saso S, Ghaem-Maghami S, Chatterjee J, et al., 2012, Abdominal radical trachelectomy in West London, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 119, Pages: 187-193, ISSN: 1470-0328
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- Citations: 38
Saso S, Logan K, Abdallah Y, et al., 2012, Use of cyclosporine in uterine transplantation., J Transplant, Vol: 2012
Uterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine graft while posing a minimal risk to the fetus. Cyclosporine A (CsA) is an immunosuppressant widely used by transplant recipients. It is currently being tested as a potential immunosuppressant to be used during UTn. Its effect on the mother and fetus and its influence upon the graft during pregnancy have been of major concern. We review the role of CsA in UTn and its effect on pregnant transplant recipients and their offspring.
Saso S, Chatterjee J, Sousa C, et al., 2011, Immunology of Uterine Transplantation, A Road Map for Human Uterus Transplantation
Soutter P, Ghaem-Maghami S, 2011, Histological recurrence and depth of loop treatment of the cervix in women of reproductive age: incomplete excision versus adverse pregnancy outcome, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 118, Pages: 1536-1536, ISSN: 1470-0328
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- Citations: 2
Davies DM, Pereira ACP, van der Stegen SJCT, et al., 2011, Flexible targeting of diverse ErbB dimers that drive tumorigenesis using genetically targeted T-cells, Publisher: MARY ANN LIEBERT INC, Pages: A118-A118, ISSN: 1043-0342
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- Citations: 1
Pereira ACP, Brewig N, Ghaem-Maghami S, et al., 2011, Immunotherapy of Epithelial Ovarian Cancer using Vγ9 Vδ2 T-cells pre-treated with Zoledronic Acid, Publisher: MARY ANN LIEBERT INC, Pages: A120-A120, ISSN: 1043-0342
Saso S, Chatterjee J, Georgiou E, et al., 2011, Endometrial cancer, BMJ-BRITISH MEDICAL JOURNAL, Vol: 343, ISSN: 1756-1833
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- Citations: 96
Ghaem-Maghami S, De-Silva D, Tipples M, et al., 2011, Determinants of success in treating cervical intraepithelial neoplasia, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 118, Pages: 679-684, ISSN: 1470-0328
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- Citations: 40
Saso S, Chatterjee J, Georgiou E, et al., 2011, Meta-analysis of survival data, An Atlas of Gynecologic Oncology, Editors: Smith, del Priore, Coleman, Monaghan, Smith, Del, Coleman, New York, USA, Publisher: InformaHealth care, ISBN: 9780415450591
Steer P, 2011, Fertility-sparing surgery for young women with early-stage cervical cancer, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 118, Pages: 377-377, ISSN: 1470-0328
Smith JR, Ghaem-Maghami S, McIndoe A, et al., 2011, Acupuncture for the induction of labour: a double-blind randomised controlled study Reply, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 118, Pages: 377-378, ISSN: 1470-0328
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- Citations: 1
Ghaem-Maghami S, Gore M, 2011, Ovarian Cancer Immunology and Immunotherapy, EMERGING THERAPEUTIC TARGETS IN OVARIAN CANCER, Editors: Kaye, Brown, Gabra, Gore, Publisher: SPRINGER, Pages: 203-221, ISBN: 978-1-4419-7215-6
Ghaem-Maghami S, 2011, Isolated groin recurrence in vulval squamous cell cancer (VSCC). The importance of node count (vol 31, pg 510, 2010), EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, Vol: 32, Pages: 4-4, ISSN: 0392-2936
Butler J, Kehoe S, Shepherd J, et al., 2010, Referrals to secondary care Referral rates for postmenopausal bleeding are not respectable, BRITISH MEDICAL JOURNAL, Vol: 341, ISSN: 1756-1833
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- Citations: 1
Butler J, Kehoe S, Shepherd J, et al., 2010, Referrals to secondary care. Referral rates for postmenopausal bleeding are not respectable., BMJ, Vol: 341
Pereira AP, Brewig N, Ghaem-Maghami S, et al., 2010, Immunotherapy of epithelial ovarian cancer using CAR engrafted T-cells: <i>in vitro</i> development, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 153-153, ISSN: 0019-2805
Brewig N, Parente-Pereira A, Maher J, et al., 2010, An <i>in</i>-<i>vivo</i> xenograft model to study simultaneous targeting of cancer cells and immunosuppressive tumour-infiltrating myeloid cells, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 151-151, ISSN: 0019-2805
Ellis PE, Ghaem-Maghami S, 2010, Molecular Characteristics and Risk Factors in Endometrial Cancer <i>What Are the Treatment and Preventative Strategies</i>?, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 20, Pages: 1207-1216, ISSN: 1048-891X
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- Citations: 8
Cloke B, Shah K, Kaneda H, et al., 2010, The poly(c)-binding protein-1 regulates expression of the androgen receptor., Endocrinology, Vol: 8, Pages: 3954-3964
The androgen receptor (AR) is a ligand-dependent transcription factor, expressed in male and female reproductive organs, and essential for normal reproduction in both sexes. The levels of AR are tightly controlled in androgen-responsive cells in which it plays a central role in the regulation of target gene expression. The AR is abundantly expressed in human endometrial stromal cells (HESCs), but levels decline markedly after differentiation into decidual cells in vivo and in primary cultures. Decidualization profoundly down-regulated AR protein levels with no discernible effect on either AR mRNA or protein stability, suggesting that loss of the receptor was a consequence of translational inhibition. Here we show that HESCs express three RNA-binding proteins, Hu antigen R and the poly(C)-binding proteins PCBP1 and PCBP2, that reportedly target the 3'-untranslated region of AR transcripts. Only PCBP1 expression was enhanced in secretory endometrium in vivo and in decidualizing HESCs. Furthermore, knockdown of PCBP1 in decidualizing cells was sufficient to restore AR protein levels, indicating that loss of the AR protein is primarily the consequence of a translational block. PCBP1 also blocked AR translation in a cell-free system, although this did not require binding to the 3'-untranslated region of the receptor mRNA. Furthermore, knockdown of PCBP1 in the prostate cancer LNCaP cell line also increased AR protein. Therefore, PCBP1 plays a major role in the dynamic expression of AR in both male and female androgen-responsive cells.
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