Imperial College London
Alternate

ProfessorSimonGregson

Faculty of Medicine, School of Public Health

Professor in Demography and Behavioural Science
 
 
 
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Contact

 

+44 (0)20 7594 3279s.gregson

 
 
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Location

 

LG27Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gregson:2017:10.1136/bmjopen-2017-015898,
author = {Gregson, S and Mugurungi, O and Eaton, J and Takaruza, A and Rhead, R and Maswera, R and Mutsangwa, J and Mayini, J and Skovdal, M and Schaefer, R and Hallett, T and Sherr, L and Munyati, S and Mason, P and Campbell, C and Garnett, G and Nyamukapa, C},
doi = {10.1136/bmjopen-2017-015898},
journal = {BMJ Open},
title = {Documenting and explaining the HIV decline in east Zimbabwe: the Manicaland General Population Cohort},
url = {http://dx.doi.org/10.1136/bmjopen-2017-015898},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose: The Manicaland Cohort was established to provide robust scientific data on HIV prevalence and incidence, patterns of sexual risk behaviour, and the demographic impact of HIV in a sub-Saharan African population subject to a generalised HIV epidemic. The aims were later broadened to include provision of data on the coverage and effectiveness of national HIV control programmes including antiretroviral treatment (ART).Participants: General population open cohort located in 12 sites in Manicaland, east Zimbabwe, representing 4 major socio-economic strata (small towns, agricultural estates, roadside settlements, and subsistence farming areas). 9,109 of 11,453 (79.5%) eligible adults (men 17-54 years; women 15-44 years) were recruited in a phased household census between July 1998 and January 2000.  Five rounds of follow-up of the prospective household census and the open cohort were conducted at 2 or 3 year intervals between July 2001 and November 2013. Follow-up rates among surviving residents ranged between 77.0% (over 3 years) and 96.4% (2 years). Findings to date: HIV prevalence was 25.1% at baseline and had a substantial demographic impact with 10-fold higher mortality in HIV-infected adults than in uninfected adults and a reduction in the growth rate in the worst affected areas (towns) from 2.9% to 1.0%pa. HIV infection rates have been highest in young adults with earlier commencement of sexual activity and in those with older sexual partners and larger numbers of lifetime partners. HIV prevalence has since fallen to 15.8% and HIV incidence has also declined from 2.1% (1998-2003) to 0.63% (2009-2013) largely due to reduced sexual risk behaviour. HIV-associated mortality fell substantially after 2009 with increased availability of ART
AU  - Gregson,S
AU  - Mugurungi,O
AU  - Eaton,J
AU  - Takaruza,A
AU  - Rhead,R
AU  - Maswera,R
AU  - Mutsangwa,J
AU  - Mayini,J
AU  - Skovdal,M
AU  - Schaefer,R
AU  - Hallett,T
AU  - Sherr,L
AU  - Munyati,S
AU  - Mason,P
AU  - Campbell,C
AU  - Garnett,G
AU  - Nyamukapa,C
DO  - 10.1136/bmjopen-2017-015898
PY  - 2017///
SN  - 2044-6055
TI  - Documenting and explaining the HIV decline in east Zimbabwe: the Manicaland General Population Cohort
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2017-015898
UR  - http://hdl.handle.net/10044/1/48342
VL  - 7
ER  -
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