Imperial College London
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Dr Shlomi Haar

Faculty of Medicine, Department of Brain Sciences

Edmond and Lily Safra Research Fellow and UK DRI Fellow
 
 
 
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Contact

 

s.haar Website

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fingher:2017:10.1016/j.cortex.2016.12.024,
author = {Fingher, N and Dinstein, I and Ben-Shachar, M and Haar, S and Dale, AM and Eyler, L and Pierce, K and Courchesne, E},
doi = {10.1016/j.cortex.2016.12.024},
journal = {Cortex},
pages = {291--305},
title = {Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers},
url = {http://dx.doi.org/10.1016/j.cortex.2016.12.024},
volume = {97},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Interhemispheric functional connectivity abnormalities are often reported in autism and it is thus not surprising that structural defects of the corpus callosum (CC) are consistently found using both traditional MRI and DTI techniques. Past DTI studies however, have subdivided the CC into 2 or 3 segments without regard for where fibers may project to within the cortex, thus placing limitations on our ability to understand the nature, timing and neurobehavioral impact of early CC abnormalities in autism. Leveraging a unique cohort of 97 toddlers (68 autism; 29 typical) we utilized a novel technique that identified seven CC tracts according to their cortical projections. Results revealed that younger (<2.5 years old), but not older toddlers with autism exhibited abnormally low mean, radial, and axial diffusivity values in the CC tracts connecting the occipital lobes and the temporal lobes. Fractional anisotropy and the cross sectional area of the temporal CC tract were significantly larger in young toddlers with autism. These findings indicate that water diffusion is more restricted and unidirectional in the temporal CC tract of young toddlers who develop autism. Such results may be explained by a potential overabundance of small caliber axons generated by excessive prenatal neural proliferation as proposed by previous genetic, animal model, and postmortem studies of autism. Furthermore, early diffusion measures in the temporal CC tract of the young toddlers were correlated with outcome measures of autism severity at later ages. These findings regarding the potential nature, timing, and location of early CC abnormalities in autism add to accumulating evidence, which suggests that altered inter-hemispheric connectivity, particularly across the temporal lobes, is a hallmark of the disorder.
AU  - Fingher,N
AU  - Dinstein,I
AU  - Ben-Shachar,M
AU  - Haar,S
AU  - Dale,AM
AU  - Eyler,L
AU  - Pierce,K
AU  - Courchesne,E
DO  - 10.1016/j.cortex.2016.12.024
EP  - 305
PY  - 2017///
SN  - 0010-9452
SP  - 291
TI  - Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers
T2  - Cortex
UR  - http://dx.doi.org/10.1016/j.cortex.2016.12.024
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418987100023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0010945217300138?via%3Dihub
UR  - http://hdl.handle.net/10044/1/79945
VL  - 97
ER  -
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