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@article{Postema:2019:10.1038/s41467-019-13005-8,
author = {Postema, MC and van, Rooij D and Anagnostou, E and Arango, C and Auzias, G and Behrmann, M and Busatto, Filho G and Calderoni, S and Calvo, R and Daly, E and Deruelle, C and Di, Martino A and Dinstein, I and Duran, FLS and Durston, S and Ecker, C and Ehrlich, S and Fair, D and Fedor, J and Feng, X and Fitzgerald, J and Floris, DL and Freitag, CM and Gallagher, L and Glahn, DC and Gori, I and Haar, S and Hoekstra, L and Jahanshad, N and Jalbrzikowski, M and Janssen, J and King, JA and Kong, XZ and Lazaro, L and Lerch, JP and Luna, B and Martinho, MM and McGrath, J and Medland, SE and Muratori, F and Murphy, CM and Murphy, DGM and O'Hearn, K and Oranje, B and Parellada, M and Puig, O and Retico, A and Rosa, P and Rubia, K and Shook, D and Taylor, MJ and Tosetti, M and Wallace, GL and Zhou, F and Thompson, PM and Fisher, SE and Buitelaar, JK and Francks, C},
doi = {10.1038/s41467-019-13005-8},
journal = {Nature Communications},
pages = {1--12},
title = {Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets},
url = {http://dx.doi.org/10.1038/s41467-019-13005-8},
volume = {10},
year = {2019}
}

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TY  - JOUR
AB  - Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen’s d = −0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.
AU  - Postema,MC
AU  - van,Rooij D
AU  - Anagnostou,E
AU  - Arango,C
AU  - Auzias,G
AU  - Behrmann,M
AU  - Busatto,Filho G
AU  - Calderoni,S
AU  - Calvo,R
AU  - Daly,E
AU  - Deruelle,C
AU  - Di,Martino A
AU  - Dinstein,I
AU  - Duran,FLS
AU  - Durston,S
AU  - Ecker,C
AU  - Ehrlich,S
AU  - Fair,D
AU  - Fedor,J
AU  - Feng,X
AU  - Fitzgerald,J
AU  - Floris,DL
AU  - Freitag,CM
AU  - Gallagher,L
AU  - Glahn,DC
AU  - Gori,I
AU  - Haar,S
AU  - Hoekstra,L
AU  - Jahanshad,N
AU  - Jalbrzikowski,M
AU  - Janssen,J
AU  - King,JA
AU  - Kong,XZ
AU  - Lazaro,L
AU  - Lerch,JP
AU  - Luna,B
AU  - Martinho,MM
AU  - McGrath,J
AU  - Medland,SE
AU  - Muratori,F
AU  - Murphy,CM
AU  - Murphy,DGM
AU  - O'Hearn,K
AU  - Oranje,B
AU  - Parellada,M
AU  - Puig,O
AU  - Retico,A
AU  - Rosa,P
AU  - Rubia,K
AU  - Shook,D
AU  - Taylor,MJ
AU  - Tosetti,M
AU  - Wallace,GL
AU  - Zhou,F
AU  - Thompson,PM
AU  - Fisher,SE
AU  - Buitelaar,JK
AU  - Francks,C
DO  - 10.1038/s41467-019-13005-8
EP  - 12
PY  - 2019///
SN  - 2041-1723
SP  - 1
TI  - Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-019-13005-8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000493438700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41467-019-13005-8
UR  - http://hdl.handle.net/10044/1/75315
VL  - 10
ER  -

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