Imperial College London
Portrait Picture

Dr Shlomi Haar

Faculty of Medicine, Department of Brain Sciences

Edmond and Lily Safra Research Fellow and UK DRI Fellow
 
 
 
//

Contact

 

s.haar Website

 
 
//

Location

 

Sir Michael Uren HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Dinstein:2017:10.1101/103788,
author = {Dinstein, I and Haar, S and Atsmon, S and Schtaerman, H},
doi = {10.1101/103788},
title = {No evidence of early head circumference enlargements in children later diagnosed with autism in Israel},
url = {http://dx.doi.org/10.1101/103788},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Large controversy exists regarding the potential existence and clinical significance of larger brain volumes in toddlers who later develop autism. Assessing this relationship is important for determining the clinical utility of early head circumference (HC) measures and for assessing the validity of the early overgrowth hypothesis of autism, which suggests that early accelerated brain development may be a hallmark of the disorder</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We performed a retrospective comparison of HC, height, and weight measurements between 66 toddlers who were later diagnosed with autism and 66 matched controls. These toddlers represent an unbiased regional sample from a single health service provider in the southern district of Israel. Using 4-12 measurements between birth and the age of two, we were able to characterize individual HC, height, and weight development with high precision and fit a negative exponential growth model to the data of each toddler with exceptional accuracy</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The analyses revealed that HC sizes and growth rates were not significantly larger in toddlers with autism even when stratifying the autism group based on verbal capabilities at the time of diagnosis. In addition, there were no significant correlations between ADOS scores at the time of diagnosis and HC at any time-point during the first two years of life</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These negative results add to accumulating evidence, which suggest that brain volume is not necessarily larger in toddlers who develop autism. While early brain overgrowth may characterize specific individuals with autism, it is
AU  - Dinstein,I
AU  - Haar,S
AU  - Atsmon,S
AU  - Schtaerman,H
DO  - 10.1101/103788
PY  - 2017///
TI  - No evidence of early head circumference enlargements in children later diagnosed with autism in Israel
UR  - http://dx.doi.org/10.1101/103788
ER  -
Download