Summary
After obtaining my first degree and PhD from the University of Leeds, my postdoctoral research at Imperial College London on nematode parasite glycosylation laid the foundations of high sensitivity mass spectrometric analysis of complex mixtures of oligosaccharides which are now widely exploited in glycomic analysis. In recognition of this work I was awarded a Young Scientist Award by the organizing and program committees of the XIVth International Symposium on Glycoconjugates, Zurich, Switzerland. This was one of seven awarded at this biennial conference and the only one to a British scientist. My more recent research has encompassed the structural analysis of glycoconjugates from diverse biological origins ranging from bacteria to humans including the analysis of several cancer derived cell lines. I was appointed to a lectureship in 2002 at Imperial College London and that year I was invited by the International Steering Committee of the Consortium for Functional Glycomics (CFG) to serve as Director of its Analytical Glycotechnology Core when this facility was re-located from San Diego to Imperial College as recommended by the CFG’s International Advisory Board. The CFG is an NIH-funded large research initiative aiming to understand the role of carbohydrate-protein interactions in cell-cell communication. Seven scientific cores provide resources to the international scientific community. The Analytical Glycotechnology Core, which is the only core to be based outside the USA, is involved in glycomic profiling of mouse and human tissues and performing carbohydrate structure analysis on carbohydrate binding protein ligands and specific mouse and human cell lines. I am also a member of the Steering Committee of the EuroCarbDB consortium which is funded by the European Commission 6th Framework Programme. This consortium aims to develop and distribute web-based carbohydrate data bases and I lead the Imperial College component which is responsible for MS activities.
Publications
Journals
Makrydaki E, Donini R, Krueger A, et al., 2024, Immobilized enzyme cascade for targeted glycosylation, Nature Chemical Biology, ISSN:1552-4450
Sammon D, Krueger A, Busse-Wicher M, et al., 2023, Molecular mechanism of decision-making in glycosaminoglycan biosynthesis, Nature Communications, Vol:14, ISSN:2041-1723
Kikuchi C, Antonopoulos A, Wang S, et al., 2023, Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines, Nature Communications, Vol:14, ISSN:2041-1723
Conference
Gimeno-Molina B, Bayar E, Mountain K, et al., 2023, The role of cervical neutrophils in cervicovaginal inflammation in women at high-risk of delivering preterm, 12th International Workshop Reunion Island Reproductive Immunology, Immunological tolerance and Immunology of preeclampsia, ELSEVIER IRELAND LTD, Pages:31-31, ISSN:0165-0378
Mountain K, MacIntyre D, Chan D, et al., 2023, ABO blood group antigens and preterm birth risk, 12th International Workshop Reunion Island Reproductive Immunology, Immunological tolerance and Immunology of preeclampsia, ELSEVIER IRELAND LTD, Pages:37-37, ISSN:0165-0378