Publications
302 results found
Graham SA, Antonopoulos A, Hitchen PG, et al., 2011, Identification of Neutrophil Granule Glycoproteins as Lewis<SUP>x</SUP>-containing Ligands Cleared by the Scavenger Receptor C-type Lectin, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 24336-24349
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- Citations: 30
Hayee B, Antonopoulos A, Murphy EJ, et al., 2011, <i>G6PC3</i> mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction, GLYCOBIOLOGY, Vol: 21, Pages: 914-924, ISSN: 0959-6658
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- Citations: 69
Barthel SR, Antonopoulos A, Cedeno-Laurent F, et al., 2011, Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of <i>N</i>- and <i>O</i>-Glycans without Direct Incorporation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 21717-21731
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- Citations: 55
Blomme B, Van Steenkiste C, Grassi P, et al., 2011, Alterations of serum protein <i>N</i>-glycosylation in two mouse models of chronic liver disease are hepatocyte and not B cell driven, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol: 300, Pages: G833-G842, ISSN: 0193-1857
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- Citations: 23
von der Lieth C-W, Freire AA, Blank D, et al., 2011, EUROCarbDB: An open-access platform for glycoinformatics, GLYCOBIOLOGY, Vol: 21, Pages: 493-502, ISSN: 0959-6658
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- Citations: 85
Campomenosi P, Cinquetti R, Tallarita E, et al., 2011, Comparison of the baculovirus-insect cell and <i>Pichia pastoris</i> heterologous systems for the expression of the human tumor suppressor protein RNASET2, BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, Vol: 58, Pages: 39-49, ISSN: 0885-4513
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- Citations: 10
Ismail MN, Stone EL, Panico M, et al., 2011, High-sensitivity <i>O</i>-glycomic analysis of mice deficient in core 2 β1,6-<i>N</i>-acetylglucosaminyltransferases, GLYCOBIOLOGY, Vol: 21, Pages: 82-98, ISSN: 0959-6658
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- Citations: 38
Stansell E, Canis K, Haslam SM, et al., 2011, Simian Immunodeficiency Virus from the Sooty Mangabey and Rhesus Macaque Is Modified with O-Linked Carbohydrate, JOURNAL OF VIROLOGY, Vol: 85, Pages: 582-595, ISSN: 0022-538X
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- Citations: 20
Wild MK, Denecke J, Straeter R, et al., 2011, A new glycosylation deficiency syndrome, Joint Meeting of the European-Society-for-Microcirculation (ESM)/Society-of-Microcirculation-and-Vascular-Biology (GfMVB), Publisher: KARGER, Pages: 204-204, ISSN: 1018-1172
Magalhaes A, Gomes J, Ismail MN, et al., 2010, Fut2-Null Mice Display An Altered Gastric Mucosa Glycosylation Profile and Modified <i>Helicobacter pylori</i> Adhesion, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1460-1461, ISSN: 0959-6658
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- Citations: 1
Dell A, Morris H, Haslam S, 2010, Functional Glycomics: The Pivotal Role of Mass Spectrometry, Annual Conference of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1450-1450, ISSN: 0959-6658
Bateman AC, Karamanska R, Busch MG, et al., 2010, Glycan Analysis and Influenza A Virus Infection of Primary Swine Respiratory Epithelial Cells <i>THE IMPORTANCE OF NeuAc</i>α<i>2-6</i> <i>GLYCANS</i>, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 34016-34026
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- Citations: 79
Lo W-Y, Lagrange AH, Hernandez CC, et al., 2010, Glycosylation of β2 Subunits Regulates GABA<sub>A</sub> Receptor Biogenesis and Channel Gating, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 31348-31361
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- Citations: 32
Picco G, Julien S, Brockhausen I, et al., 2010, Over-expression of ST3Gal-I promotes mammary tumorigenesis, GLYCOBIOLOGY, Vol: 20, Pages: 1241-1250, ISSN: 0959-6658
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- Citations: 100
Fang M, Dewaele S, Zhao Y-P, et al., 2010, Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat, MOLECULAR CANCER, Vol: 9, ISSN: 1476-4598
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- Citations: 22
Harris EN, Parry S, Sutton-Smith M, et al., 2010, <i>N-</i>Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan, GLYCOBIOLOGY, Vol: 20, Pages: 991-1001, ISSN: 0959-6658
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- Citations: 14
Garner OB, Aguilar HC, Fulcher JA, et al., 2010, Endothelial Galectin-1 Binds to Specific Glycans on Nipah Virus Fusion Protein and Inhibits Maturation, Mobility, and Function to Block Syncytia Formation, PLOS PATHOGENS, Vol: 6, ISSN: 1553-7366
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- Citations: 52
Chavele K-M, Martinez-Pomares L, Domin J, et al., 2010, Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 120, Pages: 1469-1478, ISSN: 0021-9738
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- Citations: 40
Charlier E, Conde C, Zhang J, et al., 2010, SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity, Leukemia, Vol: 24, Pages: 821-832, ISSN: 0887-6924
Takamatsu S, Antonopoulos A, Ohtsubo K, et al., 2010, Physiological and glycomic characterization of <i>N</i>-acetylglucosaminyltransferase-IVa and -IVb double deficient mice, GLYCOBIOLOGY, Vol: 20, Pages: 485-497, ISSN: 0959-6658
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- Citations: 46
Wada Y, Dell A, Haslam SM, et al., 2010, Comparison of Methods for Profiling <i>O</i>-Glycosylation HUMAN PROTEOME ORGANISATION HUMAN DISEASE GLYCOMICS/PROTEOME INITIATIVE MULTI-INSTITUTIONAL STUDY OF IgA1, MOLECULAR & CELLULAR PROTEOMICS, Vol: 9, Pages: 719-727, ISSN: 1535-9476
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- Citations: 119
Coombs PJ, Harrison R, Pemberton S, et al., 2010, Identification of Novel Contributions to High-affinity Glycoprotein-Receptor Interactions using Engineered Ligands, JOURNAL OF MOLECULAR BIOLOGY, Vol: 396, Pages: 685-696, ISSN: 0022-2836
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- Citations: 22
North SJ, Huang H-H, Sundaram S, et al., 2010, Glycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals <i>N</i>-Glycans of a Novel Size and Complexity, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 5759-5775
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- Citations: 163
North SJ, Jang-Lee J, Harrison R, et al., 2010, Chapter Two - Mass Spectrometric Analysis of Mutant Mice, Pages: 27-77, ISSN: 0076-6879
Abstract Mass spectrometry (MS) has proven to be the preeminent tool for the rapid, high-sensitivity analysis of the primary structure of glycans derived from diverse biological sources including cells, fluids, secretions, tissues, and organs. These analyses are anchored by matrix-assisted laser desorption ionization time of flight (MALDI-TOF) analysis of permethylated derivatives of glycan pools released from the samples, to produce glycomic mass fingerprints. The application of complimentary techniques, such as chemical and enzymatic digestions, GC–MS linkage analysis, and tandem mass spectrometry (MS/MS) utilizing both electrospray (ES) and MALDI-TOF/TOF, together with bioinformatic tools allows the elucidation of incrementally more detailed structural information from the sample(s) of interest. The mouse as a model organism offers many advantages in the study of human biology, health, and disease; it is a mammal, shares 99% genetic homology with humans and its genome supports targeted mutagenesis in specific genes to produce knockouts efficiently and precisely. Glycomic analyses of tissues and organs from mice genetically deficient in one or more glycosylation gene and comparison with data collected from wild-type samples enables the facile identification of changes and perturbations within the glycome. The Consortium for Functional Glycomics (CFG) has been applying such MS-based glycomic analyses to a range of murine tissues from both wild-type and glycosylation-knockout mice in order to provide a repository of structural data for the glycobiology community. In this chapter, we describe in detail the methodologies used to prepare, derivatize, purify, and analyze glycan pools from mouse organs and tissues by MS. We also present a summary of data produced from the CFG systematic structural analysis of wild-type and knockout mouse tissues, together with a detailed example of a glycomic analysis of the Mgat4a knockout mouse.
Peyfoon E, Meyer B, Hitchen PG, et al., 2010, The <i>S</i>-Layer Glycoprotein of the Crenarchaeote <i>Sulfolobus acidocaldarius</i> Is Glycosylated at Multiple Sites with Chitobiose-Linked <i>N</i>-Glycans, ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL, Vol: 2010, ISSN: 1472-3646
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- Citations: 64
Magalhaes A, Gomes J, Ismail MN, et al., 2009, Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated <i>Helicobacter pylori</i> adhesion to gastric mucosa, GLYCOBIOLOGY, Vol: 19, Pages: 1525-1536, ISSN: 0959-6658
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- Citations: 82
Karamanska R, Nichols J, Dell A, et al., 2009, Glycomic Characterization of Human and Pig Respiratory Tissues-Defining Targets for Influenza Virus, Annual Meeting of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1333-1333, ISSN: 0959-6658
Babu P, North SJ, Jang-Lee J, et al., 2009, Structural characterisation of neutrophil glycans by ultra sensitive mass spectrometric glycomics methodology, GLYCOCONJUGATE JOURNAL, Vol: 26, Pages: 975-986, ISSN: 0282-0080
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- Citations: 60
North SJ, Hitchen PG, Haslam SM, et al., 2009, Mass spectrometry in the analysis of <i>N</i>-linked and <i>O</i>-linked glycans, CURRENT OPINION IN STRUCTURAL BIOLOGY, Vol: 19, Pages: 498-506, ISSN: 0959-440X
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- Citations: 166
Montpetit ML, Stocker PJ, Schwetz TA, et al., 2009, Regulated and aberrant glycosylation modulate cardiac electrical signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 16517-16522, ISSN: 0027-8424
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- Citations: 84
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