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@article{Donini:2021:10.1042/BST20200840,
author = {Donini, R and Haslam, S and Kontoravdi, K},
doi = {10.1042/BST20200840},
journal = {Biochemical Society Transactions},
pages = {915--931},
title = {Glycoengineering Chinese hamster ovary cells: a short history},
url = {http://dx.doi.org/10.1042/BST20200840},
volume = {49},
year = {2021}
}

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TY  - JOUR
AB  - Biotherapeutic glycoproteins have revolutionised the field of pharmaceuticals, with new discoveries and continuous improvements underpinning the rapid growth of this industry. N-glycosylation is a critical quality attribute of biotherapeutic glycoproteins that influences the efficacy, half-life and immunogenicity of these drugs. This review will focus on the advances and future directions of remodelling N-glycosylation in Chinese hamster ovary (CHO) cells, which are the workhorse of recombinant biotherapeutic production, with particular emphasis on antibody products, using strategies such as cell line and protein backbone engineering.
AU  - Donini,R
AU  - Haslam,S
AU  - Kontoravdi,K
DO  - 10.1042/BST20200840
EP  - 931
PY  - 2021///
SN  - 0300-5127
SP  - 915
TI  - Glycoengineering Chinese hamster ovary cells: a short history
T2  - Biochemical Society Transactions
UR  - http://dx.doi.org/10.1042/BST20200840
UR  - http://hdl.handle.net/10044/1/87918
VL  - 49
ER  -

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