Bacterial pathogens cause many diseases in humans and are frequently well controlled by treatment with antibiotics. However, antibiotics are increasingly becoming inefficient. In addition to the well-documented cases of antibiotic resistance, persistence, characterised by relapsing infections following antibiotic treatment, is a major problem. We investigate Salmonella persisters during infection.
After completing my Ph.D. at Universite Paris 5- Necker, Paris, France, in 2006 with Dr Vladimir Pelicic, I joined the CMBI in the Department of Medicine at Imperial College London as a Research Associate in the laboratory of Prof David Holden in 2007. I have been awarded a Junior Research Fellowship by Imperial College London in 2012 and started my own research group as a Senior Research Fellow to study the formation and biology of Salmonella persisters during infection of the host in 2013. I became a senior lecturer of the MRC Centre for Molecular Bacteriology of Infection at Imperial College London and a Lister Research Prize fellow since 2017. I moved my lab to Harvard Medical School in the Department of Microbiology in summer 2019.
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et al., 2020, Salmonella effector SteE converts the mammalian serine/threonine kinase GSK3 into a tyrosine kinase to direct macrophage polarization., Cell Host and Microbe, Vol:27, ISSN:1931-3128, Pages:41-53.e6
et al., 2020, Salmonella-driven polarization of granuloma macrophages antagonizes TNF-mediated pathogen restriction during persistent infection, Cell Host and Microbe, Vol:27, ISSN:1931-3128, Pages:54-67.E5
Ronneau S, Helaine S, 2019, Clarifying the Link between Toxin-Antitoxin Modules and Bacterial Persistence, Journal of Molecular Biology, Vol:431, ISSN:0022-2836, Pages:3462-3471