Bacterial pathogens cause many diseases in humans and are frequently well controlled by treatment with antibiotics. However, antibiotics are increasingly becoming inefficient. In addition to the well-documented cases of antibiotic resistance, persistence, characterised by relapsing infections following antibiotic treatment, is a major problem. We investigate Salmonella persisters during infection.
After completing my Ph.D. at Universite Paris 5- Necker, Paris, France, in 2006 with Dr Vladimir Pelicic, I joined the CMBI in the Department of Medicine at Imperial College London as a Research Associate in the laboratory of Prof David Holden in 2007. I have been awarded a Junior Research Fellowship by Imperial College London in 2012 and started my own research group as a Senior Research Fellow to study the formation and biology of Salmonella persisters during infection of the host in 2013. I became a senior lecturer of the MRC Centre for Molecular Bacteriology of Infection at Imperial College London and a Lister Research Prize fellow since 2017. I moved my lab to Harvard Medical School in the Department of Microbiology in summer 2019.
et al., 2022, Antibiotic tolerance and persistence have distinct fitness trade-offs., Plos Pathog, Vol:18
et al., 2022, The Biological Significance of Pyruvate Sensing and Uptake in Salmonella enterica Serovar Typhimurium, Microorganisms, Vol:10
Ronneau S, Hill PWS, Helaine S, 2021, Antibiotic persistence and tolerance: not just one and the same, Current Opinion in Microbiology, Vol:64, ISSN:1369-5274, Pages:76-81
et al., 2021, Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing, Nature Chemical Biology, Vol:17, ISSN:1552-4450, Pages:1296-1304
Moldoveanu AL, Rycroft JA, Helaine S, 2021, Impact of bacterial persisters on their host, Current Opinion in Microbiology, Vol:59, ISSN:1369-5274, Pages:65-71