Imperial College London
Mr Shady G. Hosny

Mr Shady G. Hosny

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Research Fellow
 
 
 
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Contact

 

s.hosny

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Khatri:2021:10.1136/bmjopen-2021-050830,
author = {Khatri, C and Ward, AE and Nepogodiev, D and Ahmed, I and Chaudhry, D and Dhaif, F and Bankhad-Kendall, B and Kaafarani, H and Bretherton, C and Mahmood, A and Marais, L and Parsons, N and Bhangu, A and Metcalfe, A and Parsons, N and Khatri, C and Siaw-Acheampong, K and Chaudhry, D and Dawson, BE and Evans, JP and Glasbey, JC and Gujjuri, RR and Heritage, E and Jones, CS and Kamarajah, SK and Khatri, C and Keatley, JM and Lawday, S and Li, E and Mckay, SC and Nepogodiev, D and Pellino, G and Tiwari, A and Simoes, JFF and Trout, IM and Venn, ML and Wilkin, RJW and Bhangu, A and Ademuyiwa, AO and Agarwal, A and Al, Ameer E and Alderson, D and Alser, O and Arnaud, AP and Augestad, KM and Bankhead-Kendall, B and Benson, RA and Chakrabortee, S and Blanco-Colino, R and Brar, A and Bravo, AM and Breen, KA and Buarque, IL and Caruana, E and Cunha, MF and Davidson, GH and Desai, A and Di, Saverio S and Edwards, J and Elhadi, M and Farik, S and Fiore, M and Fitzgerald, JE and Ford, S and Gallo, },
doi = {10.1136/bmjopen-2021-050830},
journal = {BMJ Open},
pages = {1--10},
title = {Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study},
url = {http://dx.doi.org/10.1136/bmjopen-2021-050830},
volume = {11},
year = {2021}
}
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TY  - JOUR
AB  - Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.Setting Prospective, international, multicentre, observational cohort study.Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before t
AU  - Khatri,C
AU  - Ward,AE
AU  - Nepogodiev,D
AU  - Ahmed,I
AU  - Chaudhry,D
AU  - Dhaif,F
AU  - Bankhad-Kendall,B
AU  - Kaafarani,H
AU  - Bretherton,C
AU  - Mahmood,A
AU  - Marais,L
AU  - Parsons,N
AU  - Bhangu,A
AU  - Metcalfe,A
AU  - Parsons,N
AU  - Khatri,C
AU  - Siaw-Acheampong,K
AU  - Chaudhry,D
AU  - Dawson,BE
AU  - Evans,JP
AU  - Glasbey,JC
AU  - Gujjuri,RR
AU  - Heritage,E
AU  - Jones,CS
AU  - Kamarajah,SK
AU  - Khatri,C
AU  - Keatley,JM
AU  - Lawday,S
AU  - Li,E
AU  - Mckay,SC
AU  - Nepogodiev,D
AU  - Pellino,G
AU  - Tiwari,A
AU  - Simoes,JFF
AU  - Trout,IM
AU  - Venn,ML
AU  - Wilkin,RJW
AU  - Bhangu,A
AU  - Ademuyiwa,AO
AU  - Agarwal,A
AU  - Al,Ameer E
AU  - Alderson,D
AU  - Alser,O
AU  - Arnaud,AP
AU  - Augestad,KM
AU  - Bankhead-Kendall,B
AU  - Benson,RA
AU  - Chakrabortee,S
AU  - Blanco-Colino,R
AU  - Brar,A
AU  - Bravo,AM
AU  - Breen,KA
AU  - Buarque,IL
AU  - Caruana,E
AU  - Cunha,MF
AU  - Davidson,GH
AU  - Desai,A
AU  - Di,Saverio S
AU  - Edwards,J
AU  - Elhadi,M
AU  - Farik,S
AU  - Fiore,M
AU  - Fitzgerald,JE
AU  - Ford,S
AU  - Gallo,G
AU  - Ghosh,D
AU  - Gomes,GMA
AU  - Griffiths,E
AU  - Halkias,C
AU  - Harrison,EM
AU  - Hutchinson,P
AU  - Isik,A
AU  - Kaafarani,H
AU  - Kolias,A
AU  - Lawani,I
AU  - Lederhuber,H
AU  - Leventoglu,S
AU  - Loffler,MW
AU  - Martin,J
AU  - Mashbari,H
AU  - Mazingi,D
AU  - Mohan,H
AU  - Moore,R
AU  - Moszkowicz,D
AU  - Ng-Kamstra,JS
AU  - Metallidis,S
AU  - Moug,S
AU  - Niquen,M
AU  - Ntirenganya,F
AU  - Outani,O
AU  - Pata,F
AU  - Pinkney,TD
AU  - Pockney,P
AU  - Radenkovic,D
AU  - Ramos-De,la Medina A
AU  - Roberts,K
AU  - Santos,I
AU  - Schache,A
AU  - Schnitzbauer,A
AU  - Stewart,GD
AU  - Shaw,R
AU  - Shu,S
AU  - Soreide,K
AU  - Spinelli,A
AU  - Sundar,S
AU  - Tabiri,S
AU  - Townend,P
AU  - Tsoulfas,G
AU  - van,Ramshorst G
AU  - Vidya,R
AU  - Vimalachandran,D
AU  - Wright,N
AU  - Simoes,JFF
AU  - Mak,JKC
AU  - Kulkarni,R
AU  - Sharma,N
AU  - Nankivell,P
AU  - Tirotta,F
AU  - Parente,A
AU  - Breik,O
AU  - Kisiel,A
AU  - Cato,LD
AU  - Saeed,S
AU  - Bhangu,A
AU  - Griffiths,E
AU  - Pathanki,AM
AU  - Ford,S
AU  - Desai,A
AU  - Almond,M
AU  - Kamal,M
AU  - Chebaro,A
AU  - Lecolle,K
AU  - Truant,S
AU  - El,Amrani M
AU  - Zerbib,P
AU  - Pruvot,FR
AU  - Mathieu,D
AU  - Surmei,E
AU  - Mattei,L
AU  - Marin,H
AU  - Dudek,J
AU  - Singhal,T
AU  - El-Hasani,S
AU  - Nehra,D
AU  - Walters,A
AU  - Cuschieri,J
AU  - Davidson,GH
AU  - Ho,M
AU  - Wade,RG
AU  - Johnstone,J
AU  - Bourke,G
AU  - Brunelli,A
AU  - Elkadi,H
AU  - Otify,M
AU  - Pompili,C
AU  - Burke,JR
AU  - Bagouri,E
AU  - Chowdhury,M
AU  - Abual-Rub,Z
AU  - Kaufmann,A
AU  - Munot,S
AU  - Lo,T
AU  - Young,A
AU  - Kowal,M
AU  - Wall,J
AU  - Peckham-Cooper,A
AU  - Winter,SC
AU  - Belcher,E
AU  - Stavroulias,D
AU  - Di,Chiara F
AU  - Wallwork,K
AU  - Qureishi,A
AU  - Lami,M
AU  - Sravanam,S
AU  - Mastoridis,S
AU  - Shah,K
AU  - Chidambaram,S
AU  - Sm
DO  - 10.1136/bmjopen-2021-050830
EP  - 10
PY  - 2021///
SN  - 2044-6055
SP  - 1
TI  - Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2021-050830
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000725083500020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://bmjopen.bmj.com/content/11/11/e050830
UR  - http://hdl.handle.net/10044/1/93660
VL  - 11
ER  -
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