Imperial College London

Dr Syed Sufyan Hussain

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 4843s.hussain

 
 
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Location

 

6N6Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

30 results found

Marshall DC, Holloway M, Korer M, Woodman J, Brackenridge A, Hussain Set al., 2019, Do-it-yourself artificial pancreas systems in type 1 diabetes: perspectives of two adult users, a caregiver and three physicians, Diabetes Therapy, Vol: 10, Pages: 1553-1564, ISSN: 1869-6953

Advances in continuous glucose monitoring and insulin pumps have allowed people with type 1 diabetes (T1D) and caregivers to accurately and continuously measure their glucose levels and make adjustments to insulin infusion. In recent years, algorithms for subcutaneous insulin dosing have been developed that can respond to changes in glucose in an automated fashion and “close the loop”. At present, a first-generation ‘hybrid closed-loop’, ‘artificial pancreas’ or ‘automated insulin dosing’ system, Medtronic 670G, is available commercially. Further systems are in clinical trials. Frustrated by the slow pace of innovation, people affected by diabetes have united online under the hashtag ‘#WeAreNotWaiting,’ to disseminate open-source diabetes technologies. One dimension of #WeAreNotWaiting is “looping” with a do-it-yourself artificial pancreas. Here we provide the perspectives of two adults with T1D, the parent of a child with T1D and three physicians who detail their experience with these systems. These personal and clinical perspectives highlight very clear metabolic and psychological benefits of these systems in real-world settings.

Journal article

Mohamed IA, Fisher A, Cooper P, Hussain Set al., 2019, Use of continuous glucose monitoring in people with type 1 diabetes: Perspectives of two people with diabetes and physician perspective, Diabetes Therapy, Vol: 10, Pages: 333-340, ISSN: 1869-6953

This article details perspectives from two individuals with type 1 diabetes (T1DM) who use continuous glucose monitoring (CGM) devices to improve their quality of life and self-management of diabetes. It provides a unique perspective of how CGM can make living with T1DM safer and easier, while improving the time spent in the target glucose range (time in range). The perspectives of these two individuals highlight both the immediate need for improved access and support for CGM as well as the need for an understanding of the benefits of using non-medically approved technologies.

Journal article

Howells L, McKay AJ, Hussain S, Majeed Aet al., 2016, Management of a patient at high risk of type 2 diabetes., London Journal of Primary Care, Vol: 8, Pages: 76-79, ISSN: 1757-1472

Rates of type 2 diabetes mellitus have risen rapidly over the past three to four decades. Thisarticle describes a typical patient presenting with intermediate hyperglycaemia in primary care.We suggest the appropriate action to reduce the risk of diabetes developing. Population-levelpreventive interventions, and adequate recognition and early management of those at risk ofdeveloping diabetes, could mitigate the impact of this evolving health epidemic.

Journal article

Gardiner JV, bloom SR, Hussain S, De Backer Iet al., 2016, INSIGHTS INTO THE ROLE OF NEURONAL GLUCOKINASE, American Journal of Physiology-Endocrinology and Metabolism, Vol: 311, Pages: E42-E55, ISSN: 1522-1555

Glucokinase is a key component of the neuronal glucose-sensing mechanism and is expressed in brain regions that control a range of homeostatic processes. In this review, we detail recently identified roles for neuronal glucokinase in glucose homeostasis and counter-regulatory responses to hypoglycaemia and in regulating appetite. We describe clinical implications from these advances in our knowledge especially for developing novel treatments for diabetes and obesity. Further research required to extend our knowledge and help our efforts to tackle the diabetes and obesity epidemics are suggested.

Journal article

Hussain S, Richardson E, Ma Y, Holton C, De Backer I, Buckley N, Dhillo W, Bewick G, Zhang S, Carling D, Bloom S, Gardiner Jet al., 2015, Glucokinase activity in the arcuate nucleus regulates glucose intake, Journal of Clinical Investigation, Vol: 125, Pages: 337-384, ISSN: 1558-8238

The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-independent mechanism within the CNS that promotes glucose delivery to the brain has been postulated to maintain glucose homeostasis; however, evidence for such a mechanism is lacking. Here, we determined that glucokinase activity within the hypothalamic arcuate nucleus is involved in regulation of dietary glucose intake. In fasted rats, glucokinase activity was specifically increased in the arcuate nucleus but not other regions of the hypothalamus. Moreover, pharmacologic and genetic activation of glucokinase in the arcuate nucleus of rodent models increased glucose ingestion, while decreased arcuate nucleus glucokinase activity reduced glucose intake. Pharmacologic targeting of potential downstream glucokinase effectors revealed that ATP-sensitive potassium channel and P/Q calcium channel activity are required for glucokinase-mediated glucose intake. Additionally, altered glucokinase activity affected release of the orexigenic neurotransmitter neuropeptide Y in response to glucose. Together, our results suggest that glucokinase activity in the arcuate nucleus specifically regulates glucose intake and that appetite for glucose is an important driver of overall food intake. Arcuate nucleus glucokinase activation may represent a CNS mechanism that underlies the oft-described phenomena of the “sweet tooth” and carbohydrate craving.

Journal article

Vermont L, Hussain S, Lam SJ, Jarvis S, Cheng F, Jairam C, Jones B, Dornhorst Aet al., 2014, Investigating hypoglycaemia awareness in type 1 diabetes during pregnancy, SCOTTISH MEDICAL JOURNAL, Vol: 59, Pages: E36-E36, ISSN: 0036-9330

Journal article

Vermont L, Hussain S, Lam S, Jarvis S, Cheng F, Jairam C, Jones B, Dornhorst Aet al., 2014, PMM.46 Investigating Hypoglycaemia in Type 1 diabetes during pregnancy., Arch Dis Child Fetal Neonatal Ed, Vol: 99 Suppl 1

In pregnant type 1 diabetes patients the incidence of severe hypoglycaemia increases by 6-fold. This prospective observational study assesses the prevalence of impaired awareness of hypoglycaemia (IAH) and frequency of hypoglycaemia in pregnant type 1 diabetes patients.

Journal article

Hussain SS, Ghandi K, Dornhorst A, 2014, Investigating hypoglycaemia awareness in an outpatient type 1 diabetes clinic., DIabetes UK Annual Professional Conference

Conference paper

Hussain SS, Ghandi K, Dornhorst A, 2014, A comparison of methods used to assess impaired awareness of hypoglycaemia in Type 1 Diabetes, DIABETIC MEDICINE, Vol: 31, Pages: 129-129, ISSN: 0742-3071

Journal article

Vermont L, Hussain SS, Lam SJ, Jarvis S, Cheng F, Jairam C, Jones B, Dornhorst Aet al., 2014, Investigating hypoglycaemia awareness in Type 1 diabetes during pregnancy, DIABETIC MEDICINE, Vol: 31, Pages: 147-147, ISSN: 0742-3071

Journal article

Hussain SS, De Silva A, Bloom SR, 2014, Control of Food intake and Appetite - in Modern Nutrition in Health and Disease, Publisher: Lippincott Williams & Wilkins, ISBN: 9781605474618

Book

Hussain SS, Richardson E, Beale K, Buckley N, Bloom SR, Gardiner JVet al., 2013, A Novel Technique to Investigate Post-Prandial Responses to Sugar Solutions in Rats., Presented at the American Diabetes Association Jun 2012 (72nd scientific sessions, Philadelphia, USA)

Conference paper

Hussain SS, Bloom SR, 2013, The regulation of food intake by the gut-brain axis: implications for obesity, INTERNATIONAL JOURNAL OF OBESITY, Vol: 37, Pages: 625-633, ISSN: 0307-0565

Journal article

Hussain SS, 2013, Feeling Nervy about Diabetes? Perhaps it’s all in your head. TheEndocrinologist. http://www.endocrinology.org/endocrinologist/107/107.pdf#page=16

Report

Ali S, Hussain S M H T C, 2013, MCB: Ramadan and Diabetes: A guide for patients. http://www.mcb.org.uk/uploads/Ramadan%20and%20diabetes%20-%20A%20guide%20for%20patients%202013.pdf

Report

Hussain SS, Richardson E, Buckley N, Bewick GA, Bloom SR, Gardiner JVet al., 2013, Investigating glucose responsive neuropeptide release using a static hypothalamic incubation system, ICE/ESE Florence, 2012

Conference paper

Gandhi K, Hussain SS, Charatsi E, Dornhorst Aet al., 2013, Investigating hypoglycaemia awareness in an outpatient Type 1 diabetes clinic, DIABETIC MEDICINE, Vol: 30, Pages: 148-148, ISSN: 0742-3071

Journal article

Beale KEL, Gardiner JV, Bewick GA, Hostomska K, Patel NA, Hussain SS, Jayasena CN, Ebling FJP, Jethwa PH, Prosser HM, Lattanzi R, Negri L, Ghatei MA, Bloom SR, Dhillo WSet al., 2013, Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 403-410, ISSN: 0007-1188

Journal article

Hussain SS, 2012, Diabetes - The silent epidemic. http://healthpad.net/publication/28/the-silent-epidemic/

Report

Hussain SS, Rirchardson E, Buckley N, Bewick GA, Bloom SR, Gardiner JVet al., 2011, The effect of glucose on hypothalamic neuropeptide Y and CART release investigated using static incubation of hypothalamic explants. Endocrine Abstracts (2011) 25 P155. Presented at Society for Endocrinology, BES 2010 and presented at Endo 2010 (93rd Annual Endocrine Society meeting, USA)

Conference paper

Hussain SS, Bloom SR, 2011, The pharmacological treatment and management of obesity, Postgrad Med., Vol: 1, Pages: 34-44

Journal article

Hussein SS, Cheent KS, Khan SA, Jackson JE, Crossey MM, Thomas HC, Taylor-Robinson SDet al., 2010, Management of recurrent bleeding from facial arteriovenous malformations in end-stage liver disease., International Journal of Hepatology, Vol: 1, Pages: 53-54

We report the management by arterial embolisation of recurrent significant bleeding from a facial arteriovenous malformation (AVM) in a patient with end-stage liver disease. Given their propensity to re-bleed, AVMs are often refractory to other forms of treatment,including surgery. Evidence from the management of facial AVMs and our case suggests that embolisation may offer a better initial management strategy in patients with end-stage liver disease related facial AVMs.

Journal article

Richardson E, Hussain SS, Counsell JR, Leavy E, Bewick GA, Bloom SR, Gardiner JVet al., 2010, The Role of Ventromedial Hypothalamic Glucose-Sensing Neurons during Glucoprivation., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X

Conference paper

Hussain SS, Woolf R, Patel D, Jackson JA, Meeran Ket al., 2010, A case of a mediastinal paraganglioma. Endocrine Abstracts (2009). Presented at 4th SfE Hammersmith Multidisciplinary Endocrine Symposium and SfE National Clinical Cases meeting 2010

Conference paper

Richardson E, Hussain S, Counsell JR, Bewick GA, Bloom SR, Gardiner JVet al., 2010, Investigating the role of ventromedial hypothalamic glucose-sensing neurones in the response to hypoglycaemia. Endocrine Abstracts (2010) 21 P178. Presented at Society for Endocrinology, BES 2010, Harrogate, UK.

Conference paper

Styles K, Rastogi A, Hussain S, Abraham Set al., 2009, Methodology and results, CLINICAL MEDICINE, Vol: 9, Pages: 506-507, ISSN: 1470-2118

Journal article

Hussain SS, Harborne A, Britton M, 2008, Audit of the investigation and diagnosis of hyponatraemia in elderly medical in-patients. Endocrine Abstracts. 2008;15: P47. Presented at Society for Endocrinology, BES 2008.

Conference paper

Hussain SS, Rastogi A, Kan C, Lam A, Abraham S, Macworth-Young Cet al., 2008, Uptake of influenza vaccine in general medical patients Rheumatology 2008; 47(2): ii119 (409). Presented at the British Society for Rheumatology Annual meeting 2008

Conference paper

Hussain SS, Ebbs AM, Curtin NJ, Keidan AJet al., 2007, Delayed haemolytic transfusion reaction due to anti-Jk(b) in a patient with non-Hodgkin's lymphoma-transient nature of anti-Jk(b) and the importance of early serological diagnosis, TRANSFUSION MEDICINE, Vol: 17, Pages: 197-199, ISSN: 0958-7578

Journal article

Hurles ME, Willey D, Matthews L, Hussain SSet al., 2004, Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots., Genome Biol., Vol: 8

Journal article

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