30 results found
Marshall DC, Holloway M, Korer M, et al., 2019, Do-it-yourself artificial pancreas systems in type 1 diabetes: perspectives of two adult users, a caregiver and three physicians, Diabetes Therapy, Vol: 10, Pages: 1553-1564, ISSN: 1869-6953
Advances in continuous glucose monitoring and insulin pumps have allowed people with type 1 diabetes (T1D) and caregivers to accurately and continuously measure their glucose levels and make adjustments to insulin infusion. In recent years, algorithms for subcutaneous insulin dosing have been developed that can respond to changes in glucose in an automated fashion and “close the loop”. At present, a first-generation ‘hybrid closed-loop’, ‘artificial pancreas’ or ‘automated insulin dosing’ system, Medtronic 670G, is available commercially. Further systems are in clinical trials. Frustrated by the slow pace of innovation, people affected by diabetes have united online under the hashtag ‘#WeAreNotWaiting,’ to disseminate open-source diabetes technologies. One dimension of #WeAreNotWaiting is “looping” with a do-it-yourself artificial pancreas. Here we provide the perspectives of two adults with T1D, the parent of a child with T1D and three physicians who detail their experience with these systems. These personal and clinical perspectives highlight very clear metabolic and psychological benefits of these systems in real-world settings.
Mohamed IA, Fisher A, Cooper P, et al., 2019, Use of continuous glucose monitoring in people with type 1 diabetes: Perspectives of two people with diabetes and physician perspective, Diabetes Therapy, Vol: 10, Pages: 333-340, ISSN: 1869-6953
This article details perspectives from two individuals with type 1 diabetes (T1DM) who use continuous glucose monitoring (CGM) devices to improve their quality of life and self-management of diabetes. It provides a unique perspective of how CGM can make living with T1DM safer and easier, while improving the time spent in the target glucose range (time in range). The perspectives of these two individuals highlight both the immediate need for improved access and support for CGM as well as the need for an understanding of the benefits of using non-medically approved technologies.
Howells L, McKay AJ, Hussain S, et al., 2016, Management of a patient at high risk of type 2 diabetes., London Journal of Primary Care, Vol: 8, Pages: 76-79, ISSN: 1757-1472
Rates of type 2 diabetes mellitus have risen rapidly over the past three to four decades. Thisarticle describes a typical patient presenting with intermediate hyperglycaemia in primary care.We suggest the appropriate action to reduce the risk of diabetes developing. Population-levelpreventive interventions, and adequate recognition and early management of those at risk ofdeveloping diabetes, could mitigate the impact of this evolving health epidemic.
Glucokinase is a key component of the neuronal glucose-sensing mechanism and is expressed in brain regions that control a range of homeostatic processes. In this review, we detail recently identified roles for neuronal glucokinase in glucose homeostasis and counter-regulatory responses to hypoglycaemia and in regulating appetite. We describe clinical implications from these advances in our knowledge especially for developing novel treatments for diabetes and obesity. Further research required to extend our knowledge and help our efforts to tackle the diabetes and obesity epidemics are suggested.
Hussain S, Richardson E, Ma Y, et al., 2015, Glucokinase activity in the arcuate nucleus regulates glucose intake, Journal of Clinical Investigation, Vol: 125, Pages: 337-384, ISSN: 1558-8238
The brain relies on a constant supply of glucose, its primary fuel, for optimal function. A taste-independent mechanism within the CNS that promotes glucose delivery to the brain has been postulated to maintain glucose homeostasis; however, evidence for such a mechanism is lacking. Here, we determined that glucokinase activity within the hypothalamic arcuate nucleus is involved in regulation of dietary glucose intake. In fasted rats, glucokinase activity was specifically increased in the arcuate nucleus but not other regions of the hypothalamus. Moreover, pharmacologic and genetic activation of glucokinase in the arcuate nucleus of rodent models increased glucose ingestion, while decreased arcuate nucleus glucokinase activity reduced glucose intake. Pharmacologic targeting of potential downstream glucokinase effectors revealed that ATP-sensitive potassium channel and P/Q calcium channel activity are required for glucokinase-mediated glucose intake. Additionally, altered glucokinase activity affected release of the orexigenic neurotransmitter neuropeptide Y in response to glucose. Together, our results suggest that glucokinase activity in the arcuate nucleus specifically regulates glucose intake and that appetite for glucose is an important driver of overall food intake. Arcuate nucleus glucokinase activation may represent a CNS mechanism that underlies the oft-described phenomena of the “sweet tooth” and carbohydrate craving.
Vermont L, Hussain S, Lam SJ, et al., 2014, Investigating hypoglycaemia awareness in type 1 diabetes during pregnancy, SCOTTISH MEDICAL JOURNAL, Vol: 59, Pages: E36-E36, ISSN: 0036-9330
Vermont L, Hussain S, Lam S, et al., 2014, PMM.46 Investigating Hypoglycaemia in Type 1 diabetes during pregnancy., Arch Dis Child Fetal Neonatal Ed, Vol: 99 Suppl 1
In pregnant type 1 diabetes patients the incidence of severe hypoglycaemia increases by 6-fold. This prospective observational study assesses the prevalence of impaired awareness of hypoglycaemia (IAH) and frequency of hypoglycaemia in pregnant type 1 diabetes patients.
Hussain SS, Ghandi K, Dornhorst A, 2014, Investigating hypoglycaemia awareness in an outpatient type 1 diabetes clinic., DIabetes UK Annual Professional Conference
Hussain SS, Ghandi K, Dornhorst A, 2014, A comparison of methods used to assess impaired awareness of hypoglycaemia in Type 1 Diabetes, DIABETIC MEDICINE, Vol: 31, Pages: 129-129, ISSN: 0742-3071
Vermont L, Hussain SS, Lam SJ, et al., 2014, Investigating hypoglycaemia awareness in Type 1 diabetes during pregnancy, DIABETIC MEDICINE, Vol: 31, Pages: 147-147, ISSN: 0742-3071
Hussain SS, De Silva A, Bloom SR, 2014, Control of Food intake and Appetite - in Modern Nutrition in Health and Disease, Publisher: Lippincott Williams & Wilkins, ISBN: 9781605474618
Hussain SS, Richardson E, Beale K, et al., 2013, A Novel Technique to Investigate Post-Prandial Responses to Sugar Solutions in Rats., Presented at the American Diabetes Association Jun 2012 (72nd scientific sessions, Philadelphia, USA)
Hussain SS, Bloom SR, 2013, The regulation of food intake by the gut-brain axis: implications for obesity, INTERNATIONAL JOURNAL OF OBESITY, Vol: 37, Pages: 625-633, ISSN: 0307-0565
Hussain SS, 2013, Feeling Nervy about Diabetes? Perhaps it’s all in your head. TheEndocrinologist. http://www.endocrinology.org/endocrinologist/107/107.pdf#page=16
Ali S, Hussain S M H T C, 2013, MCB: Ramadan and Diabetes: A guide for patients. http://www.mcb.org.uk/uploads/Ramadan%20and%20diabetes%20-%20A%20guide%20for%20patients%202013.pdf
Hussain SS, Richardson E, Buckley N, et al., 2013, Investigating glucose responsive neuropeptide release using a static hypothalamic incubation system, ICE/ESE Florence, 2012
Gandhi K, Hussain SS, Charatsi E, et al., 2013, Investigating hypoglycaemia awareness in an outpatient Type 1 diabetes clinic, DIABETIC MEDICINE, Vol: 30, Pages: 148-148, ISSN: 0742-3071
Beale KEL, Gardiner JV, Bewick GA, et al., 2013, Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 168, Pages: 403-410, ISSN: 0007-1188
Hussain SS, 2012, Diabetes - The silent epidemic. http://healthpad.net/publication/28/the-silent-epidemic/
Hussain SS, Rirchardson E, Buckley N, et al., 2011, The effect of glucose on hypothalamic neuropeptide Y and CART release investigated using static incubation of hypothalamic explants. Endocrine Abstracts (2011) 25 P155. Presented at Society for Endocrinology, BES 2010 and presented at Endo 2010 (93rd Annual Endocrine Society meeting, USA)
Hussain SS, Bloom SR, 2011, The pharmacological treatment and management of obesity, Postgrad Med., Vol: 1, Pages: 34-44
Hussein SS, Cheent KS, Khan SA, et al., 2010, Management of recurrent bleeding from facial arteriovenous malformations in end-stage liver disease., International Journal of Hepatology, Vol: 1, Pages: 53-54
We report the management by arterial embolisation of recurrent significant bleeding from a facial arteriovenous malformation (AVM) in a patient with end-stage liver disease. Given their propensity to re-bleed, AVMs are often refractory to other forms of treatment,including surgery. Evidence from the management of facial AVMs and our case suggests that embolisation may offer a better initial management strategy in patients with end-stage liver disease related facial AVMs.
Richardson E, Hussain SS, Counsell JR, et al., 2010, The Role of Ventromedial Hypothalamic Glucose-Sensing Neurons during Glucoprivation., 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, ISSN: 0163-769X
Hussain SS, Woolf R, Patel D, et al., 2010, A case of a mediastinal paraganglioma. Endocrine Abstracts (2009). Presented at 4th SfE Hammersmith Multidisciplinary Endocrine Symposium and SfE National Clinical Cases meeting 2010
Richardson E, Hussain S, Counsell JR, et al., 2010, Investigating the role of ventromedial hypothalamic glucose-sensing neurones in the response to hypoglycaemia. Endocrine Abstracts (2010) 21 P178. Presented at Society for Endocrinology, BES 2010, Harrogate, UK.
Hussain SS, Harborne A, Britton M, 2008, Audit of the investigation and diagnosis of hyponatraemia in elderly medical in-patients. Endocrine Abstracts. 2008;15: P47. Presented at Society for Endocrinology, BES 2008.
Hussain SS, Rastogi A, Kan C, et al., 2008, Uptake of influenza vaccine in general medical patients Rheumatology 2008; 47(2): ii119 (409). Presented at the British Society for Rheumatology Annual meeting 2008
Hussain SS, Ebbs AM, Curtin NJ, et al., 2007, Delayed haemolytic transfusion reaction due to anti-Jk(b) in a patient with non-Hodgkin's lymphoma-transient nature of anti-Jk(b) and the importance of early serological diagnosis, TRANSFUSION MEDICINE, Vol: 17, Pages: 197-199, ISSN: 0958-7578
Hurles ME, Willey D, Matthews L, et al., 2004, Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots., Genome Biol., Vol: 8
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