Imperial College London

DrSatomiInoue

Faculty of Natural SciencesDepartment of Life Sciences

Sponsored Researcher
 
 
 
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s.inoue

 
 
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1.12Diamond Light Source LtdHarwell Science and Innovation Campus

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Summary

 

Publications

Publication Type
Year
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26 results found

Ghilarov D, Inaba-Inoue S, Stepien P, Qu F, Michalczyk E, Pakosz Z, Nomura N, Ogasawara S, Walker GC, Rebuffat S, Iwata S, Heddle JG, Beis Ket al., 2021, Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides, Science Advances, Vol: 7, Pages: 1-10, ISSN: 2375-2548

Antibiotic metabolites and antimicrobial peptides mediate competition between bacterial species. Many of them hijack inner and outer membrane proteins to enter cells. Sensitivity of enteric bacteria to multiple peptide antibiotics is controlled by the single inner membrane protein SbmA. To establish the molecular mechanism of peptide transport by SbmA and related BacA, we determined their cryo–electron microscopy structures at 3.2 and 6 Å local resolution, respectively. The structures show a previously unknown fold, defining a new class of secondary transporters named SbmA-like peptide transporters. The core domain includes conserved glutamates, which provide a pathway for proton translocation, powering transport. The structures show an outward-open conformation with a large cavity that can accommodate diverse substrates. We propose a molecular mechanism for antibacterial peptide uptake paving the way for creation of narrow-targeted therapeutics.

Journal article

Inaba S, Shiota A, Yoshida T, Oda Met al., 2019, Site-specific observation of the conformational change of a protein with N-15-labeled Tyr residues using NMR, ANALYTICAL BIOCHEMISTRY, Vol: 574, Pages: 34-38, ISSN: 0003-2697

Journal article

Oda M, Xi Z, Inaba S, Slack RL, Ishima Ret al., 2019, Binding thermodynamics of metal ions to HIV-1 ribonuclease H domain, JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, Vol: 135, Pages: 2647-2653, ISSN: 1388-6150

Journal article

Inaba S, Kamiya N, Bekker G-J, Kawai F, Oda Met al., 2019, Folding thermodynamics of PET-hydrolyzing enzyme Cut190 depending on Ca2+ concentration, JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, Vol: 135, Pages: 2655-2663, ISSN: 1388-6150

Journal article

Inaba-Inoue S, Inoue K, Hikima T, Sekiguchi H, Rambo Ret al., 2019, CRYSTAL AND SOLUTION STRUCTURES OF SH2 DOMAIN OF SIGNALING MOLECULE IN COMPLEX WITH THE CO-STIMULATORY RECEPTOR CD28, ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, Vol: 75, Pages: E69-E69, ISSN: 2053-2733

Journal article

Hosoe Y, Numoto N, Inaba S, Ogawa S, Morii H, Abe R, Ito N, Oda Met al., 2019, Structural and functional properties of Grb2 SH2 dimer in CD28 binding, BIOPHYSICS AND PHYSICOBIOLOGY, Vol: 16, Pages: 80-88

Journal article

Oda M, Yamagami Y, Inaba S, Oida T, Yamamoto M, Kitajima S, Kawai Fet al., 2018, Enzymatic hydrolysis of PET: functional roles of three Ca2+ ions bound to a cutinase-like enzyme, Cut190*, and its engineering for improved activity, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, Vol: 102, Pages: 10067-10077, ISSN: 0175-7598

Journal article

Numoto N, Kamiya N, Bekker G-J, Yamagami Y, Inaba S, Ishii K, Uchiyama S, Kawai F, Ito N, Oda Met al., 2018, Structural Dynamics of the PET-Degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-Bound States Elucidates the Ca2+-Driven Catalytic Cycle, BIOCHEMISTRY, Vol: 57, Pages: 5289-5300, ISSN: 0006-2960

Journal article

Hosoe Y, Inaba S, Sekiguchi H, Sasaki YC, Oda Met al., 2018, DNA-binding induced conformational change of c-Myb R2R3 analyzed using diffracted X-ray tracking, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 503, Pages: 338-343, ISSN: 0006-291X

Journal article

Oda M, Inaba S, Kamiya N, Bekker G-J, Mikami Bet al., 2018, Structural and thermodynamic characterization of endo-1,3-beta-glucanase: Insights into the substrate recognition mechanism, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Vol: 1866, Pages: 415-425, ISSN: 1570-9639

Journal article

Shiota A, Inaba S, Oda M, 2018, Effects of active site residues of 3-hydroxysteroid dehydrogenase from pseudomonas sp b-0831 on its catalysis and cofactor binding, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol: 82, Pages: 1702-1707, ISSN: 0916-8451

Journal article

Inaba S, Fukada H, Oda M, 2018, Effect of a salt-bridge between inter-repeats on the 3D structure of the c-Myb DNA-binding domain revealed by thermodynamic analysis, JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, Vol: 131, Pages: 335-341, ISSN: 1388-6150

Journal article

Usui D, Inaba S, Kamatari YO, Ishiguro N, Oda Met al., 2017, Light-chain residue 95 is critical for antigen binding and multispecificity of monoclonal antibody G2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 490, Pages: 1205-1209, ISSN: 0006-291X

Journal article

Usui D, Inaba S, Sekiguchi H, Sasaki YC, Tanaka T, Oda Met al., 2017, First observation of metal ion-induced structural fluctuations of alpha-helical peptides by using diffracted X-ray tracking, BIOPHYSICAL CHEMISTRY, Vol: 228, Pages: 81-86, ISSN: 0301-4622

Journal article

Miki A, Inaba S, Maruno T, Kobayashi Y, Oda Met al., 2017, Tryptophan introduction can change -glucan binding ability of the carbohydrate-binding module of endo-1,3--glucanase, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol: 81, Pages: 951-957, ISSN: 0916-8451

Journal article

Sato Y, Inaba S, Fukada H, Azuma T, Oda Met al., 2017, Pronounced effect of hapten binding on thermal stability of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain, MOLECULAR IMMUNOLOGY, Vol: 85, Pages: 130-136, ISSN: 0161-5890

Journal article

Inaba S, Numoto N, Ogawa S, Morii H, Ikura T, Abe R, Ito N, Oda Met al., 2017, Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 292, Pages: 1052-1060

Journal article

INABA S, 2017, Structural and Functional Analysis of DNA-binding Protein under Physiological Conditions, Seibutsu Butsuri, Vol: 57, Pages: 257-258, ISSN: 0582-4052

Journal article

Sato Y, Tanaka Y, Inaba S, Sekiguchi H, Maruno T, Sasaki YC, Fukada H, Kobayashi Y, Azuma T, Oda Met al., 2016, Structural dynamics of a single-chain Fv antibody against (4-hydroxy-3-nitrophenyl)acetyl, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Vol: 91, Pages: 151-157, ISSN: 0141-8130

Journal article

Oda M, Tanabe Y, Noda M, Inaba S, Krayukhina E, Fukada H, Uchiyama Set al., 2016, Structural and binding properties of laminarin revealed by analytical ultracentrifugation and calorimetric analyses, CARBOHYDRATE RESEARCH, Vol: 431, Pages: 33-38, ISSN: 0008-6215

Journal article

Inaba S, Fukada H, Oda M, 2016, Thermodynamic effects of a linker region between two repeats of a protein, c-Myb R2R3, on its stability and structural dynamics, JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, Vol: 123, Pages: 1763-1767, ISSN: 1388-6150

Journal article

Inaba S, Fukada H, Oda M, 2016, Folding thermodynamics of c-Myb DNA-binding domain in correlation with its alpha-helical contents, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Vol: 82, Pages: 725-732, ISSN: 0141-8130

Journal article

Inaba S, Maeno A, Sakurai K, Narayanan SP, Ikegami T, Akasaka K, Oda Met al., 2015, Functional conformer of c-Myb DNA-binding domain revealed by variable temperature studies, FEBS JOURNAL, Vol: 282, Pages: 4497-4514, ISSN: 1742-464X

Journal article

Miki A, Inaba S, Baba T, Kihira K, Fukada H, Oda Met al., 2015, Structural and physical properties of collagen extracted from moon jellyfish under neutral pH conditions, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Vol: 79, Pages: 1603-1607, ISSN: 0916-8451

Journal article

Inaba S, Fukada H, Ikegami T, Oda Met al., 2013, Thermodynamic effects of multiple protein conformations on stability and DNA binding, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol: 537, Pages: 225-232, ISSN: 0003-9861

Journal article

Nakabayashi M, Tsukahara Y, Iwasaki-Miyamoto Y, Mihori-Shimazaki M, Yamada S, Inaba S, Oda M, Shimizu M, Makishima M, Tokiwa H, Ikura T, Ito Net al., 2013, Crystal Structures of Hereditary Vitamin D-Resistant Rickets-Associated Vitamin D Receptor Mutants R270L and W282R Bound to 1,25-Dihydroxyvitamin D-3 and Synthetic Ligands, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 56, Pages: 6745-6760, ISSN: 0022-2623

Journal article

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