Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Honorary Research Associate







Chelsea WingRoyal Brompton Campus





Samantha Irving is an Clinical Scientist working at the NHLI researching non-invasive pulmonary function testing in children with lung disease. The main focus of her research is the multiple breath washout test, and measures of ventilation inhomogeneity.

Dr Irving completed her PhD at Imperial College in 2015.  She currently holds an NIHR Clinical Lecturer Fellowship and combines this with her clinical work at the Royal Brompton Hospital.  She is also an NIHR advocate for Health Scientists.


Irving, S. J., Ives, A., Davies, G., Donovan, J., Edey, A. J., Gill, S. S., Nair, A., Saunders, C., Wijesekera, N. T., Alton, E. W., Hansell, D., Hogg, C., Davies, J. C. & Bush, A. (2013) Lung clearance index and high-resolution computed tomography scores in primary ciliary dyskinesia. American Journal of Respiratory and Critical Care Medicine. 188 (5), 545-549.

Irving S, Carr S, Hogg C, Loebinger M, Shoemark A, Bush.  Lung Clearance Index (LCI) is Stable in Most Primary Ciliary Dyskinesia (PCD) Patients Managed in a Specialist Centre: a Pilot Study. Lung 2017 Aug;195(4):441-443.

Irving S, Dixon M, Fassad MR, Frost E, Hayward J, Kilpin K, Ollosson S, Onoufriadis A, Patel MP, Scully J, Carr SB, Mitchison HM, Loebinger MR, Hogg C, Shoemark A, Bush A. Primary Ciliary Dyskinesia Due to Microtubular Defects is Associated with Worse Lung Clearance Index. Lung 2018; 196: 231–238.

Irving S, Fleming L, Ahmad F, Biggart E, Bingham Y, Cook J, Hall P, Jamalzadeh A, Nagakumar P, Bossley C, Gupta A, Macleod K, Saglani S, Bush A. Lung clearance index (LCI) and steroid response in paediatric severe asthma. Pediatric Pulmonology 2020 Feb 6. doi: 10.1002/ppul.2467

Ahmad, F, Irving, S, Alton, EW, Davies, JC, Macleod, K, Rosenthal, MR, Saunders, C, Bush, A, Saglani, S, Fleming, L. Multi-breath washouts in children can be shortened without compromising quality European Respiratory Journal, 2015 Dec;46(6):1814-6

Grillo L, Irving S, Hansell DM, Nair A, Annan B, Ward S, Bilton D, Main E, Davies J, Bush A, Wilson R, Loebinger MR. The reproducibility and responsiveness of the lung clearance index in bronchiectasis, European Respiratory Journal 2015 Dec;46(6):1645-53.

 Downing, S. Irving, Y. Bingham, L. Fleming , A. Bush , S. Saglani Feasibility of lung clearance index in a clinical setting in pre-school children, European Respiratory Journal 2016 Oct;48(4):1074-1080.

O'Reilly R, Ullmann N, Irving S, Bossley CJ, Sonnappa S, Zhu J, Oates T, Banya W, Jeffery PK, Bush A, Saglani S. Increased airway smooth muscle in preschool wheezers who have asthma at school age.  Journal of Allergy and Clinical Immunology. 2013 Apr;131(4):1024-32,

Saunders C, Bayfield K, Irving S, Short C, Bush A, Davies JC.  Developments in multiple breath washout testing in children with cystic fibrosis. Curr Med Res Opin. 2017 Apr;33(4):613-620

Irving, S. J., Davies, J. C., Alton, E. W. & Bush, A. (2014) Lung clearance index in primary ciliary dyskinesia and bronchiectasis. American Journal of Respiratory and Critical Care Medicine. 189 (9), 1147-1148.

Bush, A. & Irving, S. (2015a) Nitrogen washout measurements of lung clearance index (LCI). Thorax. 70 (9), 896-897.

Bush, A. & Irving, S. (2015b) Wavering in the breeze: is multiple breath washout useful in primary ciliary dyskinesia? Thorax. 70 (4), 305-306.