Imperial College London

Prof Steve Matthews

Faculty of Natural SciencesDepartment of Life Sciences

Professor of Chemical and Structural Biology



+44 (0)20 7594 5315s.j.matthews Website




602Sir Ernst Chain BuildingSouth Kensington Campus





I have published over 200 papers, marrying new biological insight with quantitative and structural data.  A major focus of my group is a better understanding of the interplay between pathogenic organisms, their hosts and the environment, and defining molecular mechanisms relevant to disease. 

Selected Publications

Journal Articles

Chorev DS, Tang H, Rouse SL, et al., 2020, The use of sonicated lipid vesicles for mass spectrometry of membrane protein complexes, Nature Protocols, Vol:15, ISSN:1754-2189, Pages:1690-1706

Murphy P, Xu Y, Rouse SL, et al., 2019, Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer

Miliara X, Tatsuta T, Berry J-L, et al., 2019, Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-15

Chorev DS, Baker LA, Wu D, et al., 2018, Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry, Science, Vol:362, ISSN:0036-8075, Pages:829-+

Darvill N, Blake T, Rouse S, et al., 2018, Structural basis of phosphatidic acid sensing by APH in apicomplexan parasites, Structure, Vol:26, ISSN:0969-2126, Pages:1059-1071.e6

rouse S, hawthorne, berry, et al., 2017, A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis, Nature Communications, Vol:8, ISSN:2041-1723

Grundy GJ, Polo LM, Zeng Z, et al., 2016, PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)., Nature Communications, Vol:7, ISSN:2041-1723

Taylor JD, Hawthorne WJ, Lo J, et al., 2016, Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones, Scientific Reports, Vol:6, ISSN:2045-2322

Wong CT, Xu Y, Gupta A, et al., 2015, Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family, Nature Communications, Vol:6, ISSN:2041-1723

Matthews SJ, Miliara X, Garnett J, et al., 2015, Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes, EMBO Reports, Vol:16, ISSN:1469-221X, Pages:824-835

Evans ML, Chorell E, Taylor JD, et al., 2015, The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation, Molecular Cell, Vol:57, ISSN:1097-2765, Pages:445-455

Young JC, Clements A, Lang AE, et al., 2014, The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation, Nature Communications, Vol:5, ISSN:2041-1723

Xu Y, Plechanovova A, Simpson P, et al., 2014, Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4, Nature Communications, Vol:5, ISSN:2041-1723

Cehovin A, Simpson PJ, McDowell MA, et al., 2013, Specific DNA recognition mediated by a type IV pilin, Proceedings of the National Academy of Sciences of the United States of America, Vol:110, ISSN:0027-8424, Pages:3065-3070

Hughes S, Elustondo F, Di Fonzo A, et al., 2012, Crystal structure of human CDC7 kinase in complex with its activator DBF4, Nature Structural & Molecular Biology, Vol:19, ISSN:1545-9993, Pages:1101-+

James E, Liu M, Sheppard C, et al., 2012, Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2, Molecular Cell, Vol:47, ISSN:1097-2765, Pages:755-766

Garnett JA, Martinez-Santos VI, Saldana Z, et al., 2012, Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus, Proceedings of the National Academy of Sciences of the United States of America, Vol:109, ISSN:0027-8424, Pages:3950-3955

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