Summary
I have published over 200 papers, marrying new biological insight with quantitative and structural data. A major focus of my group is a better understanding of the interplay between pathogenic organisms, their hosts and the environment, and defining molecular mechanisms relevant to disease.
Selected Publications
Journal Articles
Vadas O, Pacheco NDS, Chao K, et al., 2023, Structural and regulatory insights into the glideosome- associated connector from Toxoplasma gondii, Elife, Vol:12, ISSN:2050-084X
Zhang K, Li S, Wang Y, et al., 2022, Bacteriophage protein PEIP is a potent<i> Bacillus</i><i> subtilis</i> enolase inhibitor, Cell Reports, Vol:40, ISSN:2211-1247
Kelsall IR, McCrory EH, Xu Y, et al., 2022, HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation, EMBO Journal, Vol:41, ISSN:0261-4189
Zhang P, Zhao X, Wang Y, et al., 2022, Bacteriophage protein Gp46 is a cross-species inhibitor of nucleoid-associated HU proteins, Proceedings of the National Academy of Sciences of the United States of America, Vol:119, ISSN:0027-8424
Murphy P, Xu Y, Rouse SL, et al., 2020, Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer, Nature Communications, Vol:11, ISSN:2041-1723
Broncel M, Dominicus C, Vigetti L, et al., 2020, Profiling of myristoylation in <i>Toxoplasma</i> <i>gondii</i> reveals an <i>N</i>-myristoylated protein important for host cell penetration, Elife, Vol:9, ISSN:2050-084X
Sewell L, Stylianou F, Xu Y, et al., 2020, NMR insights into the pre-amyloid ensemble and secretion targeting of the curli subunit CsgA, Scientific Reports, Vol:10, ISSN:2045-2322
Chorev DS, Tang H, Rouse SL, et al., 2020, The use of sonicated lipid vesicles for mass spectrometry of membrane protein complexes, Nature Protocols, Vol:15, ISSN:1754-2189, Pages:1690-1706
Matthews S, McKenna S, Malito E, et al., 2020, Structure, dynamics and immunogenicity of a catalytically inactive CXC Chemokine-degrading Protease SpyCEP from Streptococcus pyogenes, Computational and Structural Biotechnology Journal, Vol:18, ISSN:2001-0370, Pages:650-660
Murphy P, Xu Y, Rouse SL, et al., 2019, Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer
Miliara X, Tatsuta T, Berry J-L, et al., 2019, Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins, Nature Communications, Vol:10, ISSN:2041-1723, Pages:1-15
Chorev DS, Baker LA, Wu D, et al., 2018, Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry, Science, Vol:362, ISSN:0036-8075, Pages:829-+
rouse S, hawthorne, berry, et al., 2017, A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis, Nature Communications, Vol:8, ISSN:2041-1723
Hughes S, Elustondo F, Di Fonzo A, et al., 2012, Crystal structure of human CDC7 kinase in complex with its activator DBF4, Nature Structural & Molecular Biology, Vol:19, ISSN:1545-9993, Pages:1101-+
James E, Liu M, Sheppard C, et al., 2012, Structural and Mechanistic Basis for the Inhibition of <i>Escherichia coli</i> RNA Polymerase by T7 Gp2, Molecular Cell, Vol:47, ISSN:1097-2765, Pages:755-766
Garnett JA, Martinez-Santos VI, Saldana Z, et al., 2012, Structural insights into the biogenesis and biofilm formation by the <i>Escherichia coli</i> common pilus, Proceedings of the National Academy of Sciences of the United States of America, Vol:109, ISSN:0027-8424, Pages:3950-3955