Imperial College London
Alternate

Prof Steve Matthews

Faculty of Natural Sciences, Department of Life Sciences

Professor of Chemical and Structural Biology
 
 
 
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Contact

 

+44 (0)20 7594 5315s.j.matthews Website

 
 
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Location

 

602Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rouse:2018:10.1016/j.jmb.2018.05.004,
author = {Rouse, SL and Matthews, SJ and Dueholm, MS},
doi = {10.1016/j.jmb.2018.05.004},
journal = {Journal of Molecular Biology},
pages = {3685--3695},
title = {Ecology and biogenesis of functional amyloids in pseudomonas},
url = {http://dx.doi.org/10.1016/j.jmb.2018.05.004},
volume = {430},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Functional amyloids can be found in the extracellular matrix produced by many bacteria during biofilm growth. They mediate the initial attachment of bacteria to surfaces and provide stability and functionality to mature biofilms. Efficient amyloid biogenesis requires a highly coordinated system of amyloid subunits, molecular chaperones and transport systems. The functional amyloid of Pseudomonas (Fap) represents such a system. Here, we review the phylogenetic diversification of the Fap system, its potential ecological role and the dedicated machinery required for Fap biogenesis, with a particular focus on the amyloid exporter FapF, the structure of which has been recently resolved. We also present a sequence covariance-based in silico model of the FapC fiber-forming subunit. Finally, we highlight key questions that remain unanswered and we believe deserve further attention by the scientific community.
AU  - Rouse,SL
AU  - Matthews,SJ
AU  - Dueholm,MS
DO  - 10.1016/j.jmb.2018.05.004
EP  - 3695
PY  - 2018///
SN  - 0022-2836
SP  - 3685
TI  - Ecology and biogenesis of functional amyloids in pseudomonas
T2  - Journal of Molecular Biology
UR  - http://dx.doi.org/10.1016/j.jmb.2018.05.004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29753779
UR  - http://hdl.handle.net/10044/1/60323
VL  - 430
ER  -
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