Imperial College London
Alternate

ProfessorSebastianJohnston

Faculty of Medicine, National Heart & Lung Institute

Asthma UK Clinical Chair
 
 
 
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Contact

 

+44 (0)7931 376 544s.johnston

 
 
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Assistant

 

Mr Christophe Tytgat +44 (0)20 7594 3849

 
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Location

 

343Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

753 results found

Dumitrascu D, Sanderson G, Mukaida N, Matsushima K, Holgate ST, Johnston SLet al., 1997, IL-8 AP-1 and kappa B-like sites are necessary for rhinovirus induction of IL-8 promoter activity in A549 cell., Publisher: MOSBY-YEAR BOOK INC, Pages: 1639-1639, ISSN: 0091-6749

Conference paper

Thomas LH, Papi A, Johnston SL, Warner Jet al., 1997, Effects of epithelial cell supernatants (ECS) on leukocyte function., Publisher: MOSBY-YEAR BOOK INC, Pages: 510-510, ISSN: 0091-6749

Conference paper

Johnston SL, 1997, Bronchial hyperresponsiveness and cytokines in virus-induced asthma exacerbations, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 27, Pages: 7-9, ISSN: 0954-7894

Journal article

Frew AJ, Bradding P, Johnston SL, Lackie P, Semper A, Shute A, Walls AF, Holgate STet al., 1997, Allergy, Mechanisms of Disease, Editors: Tomlinson, Heagerty, Weetman, UK, Publisher: Cambridge University Press, Pages: 129-159

Book chapter

Johnston SL, 1997, Influence of viral and bacterial respiratory infections on exacerbations and symptom severity in childhood asthma, PEDIATRIC PULMONOLOGY, Pages: 88-89, ISSN: 8755-6863

Journal article

Johnston SL, Pattemore PK, Sanderson G, Smith S, Campbell MJ, Josephs LK, Cunningham A, Robinson BS, Myint SH, Ward ME, Tyrrell DAJ, Holgate STet al., 1996, The relationship between upper respiratory infections and hospital admissions for asthma: A time-trend analysis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 154, Pages: 654-660, ISSN: 1073-449X

Journal article

Johnston SL, 1996, Cromolyns: Treatment for the common cold?, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 26, Pages: 989-994, ISSN: 0954-7894

Journal article

Rajakulasingam K, Johnston SL, Ducey J, Ritter W, Howarth PH, Holgate STet al., 1996, Effect of thromboxane A(2)-receptor antagonist on bradykinin-induced bronchoconstriction in asthma, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 80, Pages: 1973-1977, ISSN: 8750-7587

Journal article

Lindsay MA, Daniels I, Fletcher J, 1996, Investigation of the role of protein kinase C and tyrosine kinases during the rapid and sustained release of superoxide from adherent human neutrophils., Biochem Soc Trans, Vol: 24, ISSN: 0300-5127

Journal article

Cunningham A, Johnston SL, Julious SA, Lampe FC, Ward MEet al., 1996, Association between nasal sIGA to chronic Chlamydia pneumoniae infection and asthma exacerbations in children., Publisher: MOSBY-YEAR BOOK INC, Pages: 492-492, ISSN: 0091-6749

Conference paper

Papi A, Johnston SL, 1996, Rhinovirus infection increases ICAM-1 expression in pulmonary epithelium., Publisher: MOSBY-YEAR BOOK INC, Pages: 684-684, ISSN: 0091-6749

Conference paper

Johnston SL, Holgate ST, 1996, Epidemiology of respiratory tract infections, Viral and other infections of the human respiratory tract, Editors: Myint, Taylor-Robinson, London, Publisher: Chapman & Hall, Pages: 1-38

Book chapter

Johnston SL, 1996, Viral infections in children with existing asthma, From Genetics to Quality of Life, Editors: Chanez, Bousquet, Michel, Godard, Publisher: Hogrefe & Huber Pubs, Pages: 102-107

Book chapter

JOHNSTON SL, 1995, NATURAL AND EXPERIMENTAL RHINOVIRUS INFECTIONS OF THE LOWER RESPIRATORY-TRACT, 10th Transatlantic Airway Conference on the Biology of Viral Infections, Publisher: AMER LUNG ASSOC, Pages: S46-S52, ISSN: 1073-449X

Conference paper

JOHNSTON SL, PATTEMORE PK, SANDERSON G, SMITH S, LAMPE F, JOSEPHS L, SYMINGTON P, OTOOLE S, MYINT SH, TYRRELL DAJ, HOLGATE STet al., 1995, COMMUNITY STUDY OF ROLE OF VIRAL-INFECTIONS IN EXACERBATIONS OF ASTHMA IN 9-11 YEAR-OLD CHILDREN, BRITISH MEDICAL JOURNAL, Vol: 310, Pages: 1225-1229, ISSN: 0959-8138

Journal article

FRAENKEL DJ, BARDIN PG, SANDERSON G, LAMPE F, JOHNSTON SL, HOLGATE STet al., 1995, LOWER AIRWAYS INFLAMMATION DURING RHINOVIRUS COLDS IN NORMAL AND IN ASTHMATIC SUBJECTS, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 151, Pages: 879-886, ISSN: 1073-449X

Journal article

JOHNSTON SL, FREEZER NJ, RITTER W, OTOOLE S, HOWARTH PHet al., 1995, PROSTAGLANDIN D-2-INDUCED BRONCHOCONSTRICTION IS MEDIATED ONLY IN PART BY THE THROMBOXANE PROSTANOID RECEPTOR, EUROPEAN RESPIRATORY JOURNAL, Vol: 8, Pages: 411-415, ISSN: 0903-1936

Journal article

SEMINARIO MC, SQUILLACE D, BARDIN PG, FRAENKEL DJ, GLEICH GJ, JOHNSTON SLet al., 1995, INCREASED LEVELS OF EOSINOPHIL MAJOR BASIC-PROTEIN IN NASAL SECRETIONS IN RHINOVIRUS INFECTION, Publisher: MOSBY-YEAR BOOK INC, Pages: 259-259, ISSN: 0091-6749

Conference paper

JOHNSTON SL, DAVIES M, LAU LCK, WALTERS C, WALLS AF, PROUD D, HOWARTH PHet al., 1995, PRIOR LOCAL HYPERTHERMIA REDUCES NASAL BLOCKAGE, VASCULAR LEAKAGE AND MEDIATOR RELEASE AFTER NASAL ALLERGEN CHALLENGE, Publisher: MOSBY-YEAR BOOK INC, Pages: 192-192, ISSN: 0091-6749

Conference paper

Johnston SL, Tyrrell DAJ, 1995, Rhinoviruses, Diagnostic procedures for viral, rickettsial and chlamydial infections, Editors: Lennette, Schmidt, Washington DC, Publisher: American Public Health Association, Pages: 553-563

Book chapter

THOMAS LH, FRAENKEL DJ, BARDIN PG, JOHNSTON SL, HOLGATE ST, WARNER JAet al., 1994, LEUKOCYTE RESPONSES TO EXPERIMENTAL-INFECTION WITH HUMAN RHINOVIRUS, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 94, Pages: 1255-1262, ISSN: 0091-6749

Journal article

FRAENKEL DJ, BARDIN PG, SANDERSON G, LAMPE F, JOHNSTON SL, HOLGATE STet al., 1994, IMMUNOHISTOCHEMICAL ANALYSIS OF NASAL BIOPSIES DURING RHINOVIRUS EXPERIMENTAL COLDS, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 150, Pages: 1130-1136, ISSN: 1073-449X

Journal article

Johnston SL, Dalal A, Mason S, Wilson JW, Robinson BS, Holgate STet al., 1994, Detection of respiratory syncytial virus infection in nasal aspirate samples by flow cytometry., Clin Diagn Virol, Vol: 2, Pages: 279-289, ISSN: 0928-0197

HYPOTHESES: (i) Flow cytometry has the potential for rapid detection of respiratory viral antigens. (ii) This technique can be applied to viral diagnosis in clinical samples. OBJECTIVES AND STUDY DESIGN: (i) To study the identification of six common respiratory viral pathogens by flow cytometry, in virus infected and uninfected cultured cells, as models of positive and negative clinical samples. (ii) To compare flow cytometry with the established techniques of viral isolation and immunofluorescent microscopy in the diagnosis of respiratory syncytial virus infection in 68 naso-pharyngeal aspirates taken from children and sent to the virology laboratory for routine virological diagnosis. RESULTS: (i) For each virus analysed, populations of infected and non-infected cells were clearly discernable, confirming potential for this method in rapid viral diagnosis in clinical samples. (ii) Two definitions were employed for a sample to be positive by flow cytometry, these were compared with the combined established techniques. The sensitivity, specificity, positive and negative predictive values of flow cytometry were 41%, 98%, 92% and 71% for the first definition and 74%, 88%, 80% and 84% for the second definition respectively. CONCLUSIONS: As tested in this study, flow cytometry is less sensitive than established techniques as well as recently developed rapid diagnostic techniques for the diagnosis of respiratory syncytial virus infection. Further evaluation of the potential of flow cytometry in rapid viral diagnosis is warranted.

Journal article

OHLIN A, HOOVERLITTY H, SANDERSON G, PAESSENS A, JOHNSTON SL, HOLGATE ST, HUGUENEL E, GREVE JMet al., 1994, SPECTRUM OF ACTIVITY OF SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 AGAINST RHINOVIRUS REFERENCE STRAINS AND FIELD ISOLATES, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 38, Pages: 1413-1415, ISSN: 0066-4804

Journal article

SPENCE DPS, JOHNSTON SL, CALVERLEY PMA, DHILLON P, HIGGINS C, RAMHAMADANY E, TURNER S, WINNING A, WINTER J, HOLGATE STet al., 1994, THE EFFECT OF THE ORALLY-ACTIVE PLATELET-ACTIVATING-FACTOR ANTAGONIST WEB-2086 IN THE TREATMENT OF ASTHMA, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 149, Pages: 1142-1148, ISSN: 1073-449X

Journal article

BARDIN PG, FRAENKEL DJ, SANDERSON G, DORWARD M, LAU LCK, JOHNSTON SL, HOLGATE STet al., 1994, AMPLIFIED RHINOVIRUS COLDS IN ATOPIC SUBJECTS, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 24, Pages: 457-464, ISSN: 0954-7894

Journal article

BARDIN PG, JOHNSTON SL, SANDERSON G, ROBINSON BS, PICKETT MA, FRAENKEL DJ, HOLGATE STet al., 1994, DETECTION OF RHINOVIRUS INFECTION OF THE NASAL-MUCOSA BY OLIGONUCLEOTIDE IN-SITU HYBRIDIZATION, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 10, Pages: 207-213, ISSN: 1044-1549

Journal article

CHANARIN N, JOHNSTON SL, 1994, LEUKOTRIENES AS A TARGET IN ASTHMA THERAPY, DRUGS, Vol: 47, Pages: 12-24, ISSN: 0012-6667

Journal article

TERAN LM, JOHNSTON SL, SHUTE JK, CHURCH MK, HOLGATE STet al., 1994, INCREASED LEVELS OF INTERLEUKIN-8 IN THE NASAL ASPIRATES OF CHILDREN WITH VIRUS-ASSOCIATED ASTHMA, Publisher: MOSBY-YEAR BOOK INC, Pages: 272-272, ISSN: 0091-6749

Conference paper

Cunningham A, Johnston SL, Julious S, Ward Met al., 1994, The role of chlamydia pneumoniae and other pathogens in acute episodes of asthma, Proceedings of the Eighth Symposium on Human Chlamydia Infections, Editors: Orfilla, Pages: 480-484

Book chapter

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