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@article{Dhariwal:2022:10.1183/2312508X.10030120,
author = {Dhariwal, J and Padayachee, Y and Johnston, SL},
doi = {10.1183/2312508X.10030120},
journal = {ERS Monograph},
pages = {204--218},
title = {Respiratory viruses and eosinophilic airway inflammation},
url = {http://dx.doi.org/10.1183/2312508X.10030120},
volume = {2022},
year = {2022}
}

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TY  - JOUR
AB  - Eosinophils are widely acknowledged as key cells in driving type 2 immune responses against parasitic infection and in mediating allergic disease. Advances in our understanding have suggested that eosinophils may play an important additional role in the host immune response against a range of respiratory virus infections in both health and disease. Eosinophils exert these effects through a diverse range of mechanisms spanning innate and adaptive immunity, including immune sensing via Toll-like receptors, acting as antigen-presenting cells and the secretion of potent antiviral molecules. Recent evidence that anti-IL-5/IL-5 receptor therapies markedly reduce asthma exacerbations in those with activated eosinophilic pathways indicates that eosinophils clearly play an important role in asthma exacerbation pathogenesis. The mechanisms of viral exacerbations in patients treated with biologics are not yet fully understood and further work is needed to assess the impact of eosinophil depletion in this patient cohort.
AU  - Dhariwal,J
AU  - Padayachee,Y
AU  - Johnston,SL
DO  - 10.1183/2312508X.10030120
EP  - 218
PY  - 2022///
SN  - 2312-508X
SP  - 204
TI  - Respiratory viruses and eosinophilic airway inflammation
T2  - ERS Monograph
UR  - http://dx.doi.org/10.1183/2312508X.10030120
VL  - 2022
ER  -

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