Publications
381 results found
Ewing AV, Biggart GD, Hale CR, et al., 2015, Comparison of pharmaceutical formulations: ATR-FTIR spectroscopic imaging to study drug-carrier interactions, INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 495, Pages: 112-121, ISSN: 0378-5173
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- Citations: 22
Gabrienko AA, Martyanov ON, Kazarian SG, 2015, Effect of Temperature and Composition on the Stability of Crude Oil Blends Studied with Chemical Imaging <i>in Situ</i>, ENERGY & FUELS, Vol: 29, Pages: 7114-7123, ISSN: 0887-0624
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- Citations: 21
Chan KLA, Kazarian SG, 2015, Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells, Chemical Society Reviews, Vol: 45, Pages: 1850-1864, ISSN: 1460-4744
FTIR spectroscopic imaging is a label-free, non-destructive and chemically specific technique that can be utilised to study a wide range of biomedical applications such as imaging of biopsy tissues, fixed cells and live cells, including cancer cells. In particular, the use of FTIR imaging in attenuated total reflection (ATR) mode has attracted much attention because of the small, but well controlled, depth of penetration and corresponding path length of infrared light into the sample. This has enabled the study of samples containing large amounts of water, as well as achieving an increased spatial resolution provided by the high refractive index of the micro-ATR element. This review is focused on discussing the recent developments in FTIR spectroscopic imaging, particularly in ATR sampling mode, and its applications in the biomedical science field as well as discussing the future opportunities possible as the imaging technology continues to advance.
Wrobel TP, Vichi A, Baranska M, et al., 2015, Micro-Attenuated Total Reflection Fourier Transform Infrared (Micro ATR FT-IR) Spectroscopic Imaging with Variable Angles of Incidence, APPLIED SPECTROSCOPY, Vol: 69, Pages: 1170-1174, ISSN: 0003-7028
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- Citations: 20
Sroka-Bartnicka A, Kimber JA, Borkowski L, et al., 2015, The biocompatibility of carbon hydroxyapatite/β-glucan composite for bone tissue engineering studied with Raman and FTIR spectroscopic imaging, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 407, Pages: 7775-7785, ISSN: 1618-2642
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- Citations: 33
Kharintsev SS, Fishman AI, Kazarian SG, et al., 2015, Polarization of near-field light induced with a plasmonic nanoantenna, PHYSICAL REVIEW B, Vol: 92, ISSN: 1098-0121
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- Citations: 13
Ewing AV, Wray PS, Clarke GS, et al., 2015, Evaluating drug delivery with salt formation: Drug disproportionation studied in situ by ATR-FTIR imaging and Raman mapping, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 111, Pages: 248-256, ISSN: 0731-7085
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- Citations: 28
Byrne B, Kazarian SG, Boulet-Audet M, 2015, Cleaning-in-place for immunoaffinity resin monitored by in situ ATR-FTIR spectroscopy, Analytical and Bioanalytical Chemistry, Vol: 407, Pages: 7111-7122, ISSN: 1618-2650
In the next ten years, the pharmaceutical industry anticipates that revenue from biotherapeutics will overtake those generated from small drug molecules. Despite effectively treating a range of chronic and life-threatening diseases, the high cost of biotherapeutics limits their use. For biotherapeutic monoclonal antibodies (mAbs), an important production cost is the affinity resin used for protein capture. Cleaning-in-place (CIP) protocols aim to optimise the lifespan of the resin by slowing binding capacity decay. Binding assays can determine resin capacity from the mobile phase, but do not reveal the underlying causes of Protein A ligand degradation. The focus needs to be on the stationary phase to examine the effect of CIP on the resin. To directly determine both the local Protein A ligand concentration and conformation on two Protein A resins, we developed a method based on attenuated total reflection (ATR) Fourier Transform Infrared (FTIR) spectroscopy. ATR-FTIR spectroscopic imaging revealed that applying a carefully controlled load to agarose beads produces an even and reproducible contact with the internal reflection element. This allowed detection and quantification of the binding capacity of the stationary phase. ATR-FTIR also showed that Protein A proteolysis does not seem to occur under typical CIP conditions (below 1M NaOH). However, our data revealed that concentrations of NaOH above 0.1 M cause significant changes in Protein A conformation. The addition of >0.4 M trehalose during CIP significantly reduced NaOH-induced ligand unfolding observed for one of the two Protein A resins tested. Such insights could help to optimise CIP protocols in order to extend resin lifetime and reduce mAb production costs.
Puncochova K, Ewing AV, Gajdosova M, et al., 2015, Identifying the mechanisms of drug release from amorphous solid dispersions using MRI and ATR-FTIR spectroscopic imaging, INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol: 483, Pages: 256-267, ISSN: 0378-5173
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- Citations: 44
Gabrienko AA, Morozov EV, Subramani V, et al., 2015, Chemical Visualization of Asphaltenes Aggregation Processes Studied in Situ with ATR-FTIR Spectroscopic Imaging and NMR Imaging, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 119, Pages: 2646-2660, ISSN: 1932-7447
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- Citations: 46
Kimber JA, Kazarian SG, 2015, Macro ATR-FT-IR Spectroscopic Imaging of Dynamic Processes, SPECTROSCOPY, Pages: 17-23, ISSN: 0887-6703
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- Citations: 2
Pudlas M, Kyeremateng SO, Williams LAM, et al., 2015, Analyzing the impact of different excipients on drug release behavior in hot-melt extrusion formulations using FTIR spectroscopic imaging, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 67, Pages: 21-31, ISSN: 0928-0987
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- Citations: 26
Dattani R, Gibson KF, Few S, et al., 2015, Fullerene oxidation and clustering in solution induced by light, Journal of Colloid and Interface Science, Vol: 446, Pages: 24-30, ISSN: 1095-7103
We investigate the environmental stability of fullerene solutions by static and dynamic light scattering, FTIR, NMR and mass spectroscopies, and quantum chemical calculations. We find that visible light exposure of fullerene solutions in toluene, a good solvent, under ambient laboratory conditions results in C60 oxidation to form fullerene epoxides, and subsequently causes fullerene clustering in solution. The clusters grow with time, even in absence of further illumination, and can reach dimensions from ≈100 nm to the μm scale over ≈1 day. Static light scattering suggests that resulting aggregates are fractal, with a characteristic power law (df) that increases from approximately 1.3 to 2.0 during light exposure. The clusters are bound by weak Coulombic interactions and are found to be reversible, disintegrating by mechanical agitation and thermal stress, and reforming over time. Our findings are relevant to the solution processing of composites and organic photovoltaics, whose reproducibility and performance requires control of fullerene solution stability under storage conditions.
Ewing AV, Gabrienko AA, Semikolenov SV, et al., 2015, How Do Intermolecular Interactions Affect Swelling of Polyketones with a Differing Number of Carbonyl Groups? An In Situ ATR-FTIR Spectroscopic Study of CO<sub>2</sub> Sorption in Polymers, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 119, Pages: 431-440, ISSN: 1932-7447
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- Citations: 25
Ewing AV, Kazarian SG, 2015, Interaction of supercritical carbon dioxide with polymers studied by vibrational spectroscopy, Supercritical Fluid Nanotechnology: Advances and Applications in Composites and Hybrid Nanomaterials, Pages: 481-516, ISBN: 9789814613408
High-pressure and supercritical CO2 (scCO2) have the potential to be employed as viable alternatives to the harmful volatile organic solvents (VOCs) currently used for industrial processes. Developments using this technology are driven by our society continuing to move towards environmentally friendly processes. As well as conforming to the modern industrial environmental requirements, high-pressure and scCO2 offer fundamental advantages for polymer processing that include the reduction of polymer melting temperatures (Tm) and glass transition temperatures (Tg) and can induce polymer swelling. These effects are crucial to the modification of polymeric samples. Thus, the importance of processing polymeric materials with CO2 can lead to the production of novel resources that have unique characteristics and properties. This book chapter will review developments discovered by the use of vibrational spectroscopic approaches, specifically infrared and Raman spectroscopy. Vibrational spectroscopy can reveal valuable information about the polymeric samples, as well as highlighting interactions between CO2and the functional groups present within the polymeric materials. Understanding the behaviour of these systems is integral as a means to develop more efficient processing routes. Finally, the most recent advancements in this field will be summarized with an outlook to future opportunities using this “green” processing technology. 19.1 IntroductionIn this chapter we review some of the most important discoveries associated with the use of supercritical fluids (SCFs) for polymer processing. The unique physical properties that SCFs possess give great potential to study a range of different systems, not only in polymer science, but in areas such as organic synthesis, catalysis and coordination chemistry [1, 2]. Applications using SCFs, specifically supercritical carbon dioxide (scCO2), is a growing area for industrial processes, which has been motivated by the need f
Ishikawa D, Furukawa D, Wei TT, et al., 2015, High-speed monitoring of the crystallinity change in poly(lactic acid) during photodegradation by using a newly developed wide area NIR imaging system (Compovision), ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 407, Pages: 397-403, ISSN: 1618-2642
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- Citations: 10
Chew J, Joshi HM, Kazarian SG, et al., 2015, Deposit Characterization and Measurements, CRUDE OIL FOULING: DEPOSIT CHARACTERIZATION, MEASUREMENTS, AND MODELING, Editors: Coletti, Hewitt, Publisher: GULF PROFESSIONAL PUBL, Pages: 95-178, ISBN: 978-0-12-801256-7
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- Citations: 7
Foreman L, Kimber JA, Oliver KV, et al., 2015, Assessing Dysplasia of a Bronchial Biopsy with FTIR Spectroscopic Imaging, Conference on Optical Diagnostics and Sensing XV - Toward Point-of-Care Diagnostics, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 8
Kimber JA, Gerst M, Kazarian SG, 2014, Fast Drying and Film Formation of Latex Dispersions Studied with FTIR Spectroscopic Imaging, Langmuir, Vol: 30, Pages: 13588-13595, ISSN: 1520-5827
Drying of thin latex films (∼20 μm) at high drying speeds (of the order of seconds) has been studied by fast chemical imaging. ATR-FTIR spectroscopic imaging combined with a fast “kinetic” mode was used to acquire spectral images without coaddition, enabling the amount of water and homogeneity of the drying film to be studied over time. Drying profiles, constructed from analyzing the water content in each image, show two stages of drying, a fast and a slow region. The formulation of latex dispersions affects the onset of slow drying and the volume fraction of water remaining at the onset of slow drying. In this work, the effect of physical properties, film thickness and glass transition temperature (Tg), were investigated, as well as the effect of monomer composition where two monomoers, 2-ethylhexyl acrylate and n-butyl acrylate, and the amount of hydrophilic comonomer, methyl methacrylate (MMA), were varied. It was found that thicker films produced slower overall drying and that the formulation with a Tg above the minimum film formation temperature did not dry evenly, exhibiting cracking. However, the drying kinetics of high and low Tg films were similar, highlighting the advantage of using a spatially-resolved spectroscopic approach. Formulations containing more MMA dried faster than those with less. This was due to the hydrophilicity of MMA and the increase in Tg of the dispersion from the addition of MMA. Overall, FTIR spectroscopic imaging was shown to be a suitable approach in measuring film drying at high speeds as both chemical changes and chemical distribution could be analyzed over time.
Dougan JA, Andrew Chan KL, Kazarian SG, 2014, FT-IR Imaging in ATR and Transmission Modes: Practical Considerations and Emerging Applications, Infrared and Raman Spectroscopic Imaging: Second Edition, Pages: 397-444, ISBN: 9783527336524
A range of approaches and applications of Fourier transform infrared (FT-IR) imaging have been developed in both attenuated total reflection (ATR) and transmission modes for a broad range of materials and chemical systems. This chapter describes some general principles and applications of FT-IR imaging in ATR and transmission mode with a focus on technical considerations, new developments, and emerging applications. It discusses the advantages and limitations of the two imaging approaches (transmission and ATR) in terms of spatial resolution, image field of view (FOV), and possible artifacts. The chapter also discusses the novel developments including a new diamond ATR accessory specifically designed for imaging applications, an inverted-prism expanded FOV (ZnSe) ATR accessory with expanding lenses, ATR imaging with variable angles of incidence ATR accessory. The different FOVs and spatial resolutions of different ATR accessories are also summarized and described in the chapter.
Boulet-Audet M, Byrne B, Kazarian SG, 2014, High-throughput thermal stability analysis of a monoclonal antibody by attenuated total reflection FT-IR spectroscopic imaging, Analytical Chemistry, Vol: 86, Pages: 9786-9793, ISSN: 0003-2700
The use of biotherapeutics, such as monoclonal antibodies, has markedly increased in recent years. It is thus essential that biotherapeutic production pipelines are as efficient as possible. For the production process, one of the major concerns is the propensity of a biotherapeutic antibody to aggregate. In addition to reducing bioactive material recovery, protein aggregation can have major effects on drug potency and cause highly undesirable immunological effects. It is thus essential to identify processing conditions which maximize recovery while avoiding aggregation. Heat resistance is a proxy for long-term aggregation propensity. Thermal stability assays are routinely performed using various spectroscopic and scattering detection methods. Here, we evaluated the potential of macro attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopic imaging as a novel method for the high-throughput thermal stability assay of a monoclonal antibody. This chemically specific visualization method has the distinct advantage of being able to discriminate between monomeric and aggregated protein. Attenuated total reflection is particularly suitable for selectively probing the bottom of vessels, where precipitated aggregates accumulate. With focal plane array detection, we tested 12 different buffer conditions simultaneously to assess the effect of pH and ionic strength on protein thermal stability. Applying the Finke model to our imaging kinetics allowed us to determine the rate constants of nucleation and autocatalytic growth. This analysis demonstrated the greater stability of our immunoglobulin at higher pH and moderate ionic strength, revealing the key role of electrostatic interactions. The high-throughput approach presented here has significant potential for analyzing the stability of biotherapeutics as well as any other biological molecules prone to aggregation.
Kharintsev SS, Fishman AI, Kazarian SG, et al., 2014, Experimental Evidence for Axial Anisotropy beyond the Diffraction Limit Induced with a Bias Voltage Plasmonic Nanoantenna and Longitudinal Optical Near-Fields in Photoreactive Polymer Thin Films, ACS PHOTONICS, Vol: 1, Pages: 1025-1032, ISSN: 2330-4022
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- Citations: 11
Kimber JA, Kazarian SG, 2014, Macro ATR-FT-IR Spectroscopic Imaging of Dynamic Processes, SPECTROSCOPY, Vol: 29, Pages: 34-+, ISSN: 0887-6703
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- Citations: 5
Trukhan SN, Yudanov VF, Gabrienko AA, et al., 2014, <i>In Situ</i> Electron Spin Resonance Study of Molecular Dynamics of Asphaltenes at Elevated Temperature and Pressure, ENERGY & FUELS, Vol: 28, Pages: 6315-6321, ISSN: 0887-0624
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- Citations: 31
Ewing AV, Clarke GS, Kazarian SG, 2014, Stability of indomethacin with relevance to the release from amorphous solid dispersions studied with ATR-FTIR spectroscopic imaging, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 60, Pages: 64-71, ISSN: 0928-0987
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- Citations: 56
Morozov EV, Trukhan SN, Larichev YV, et al., 2014, In-situ studies of crude oil stability and direct visualization of asphaltenes aggregation processes via some spectroscopy techniques, 248th National Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
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- Citations: 1
Hojniak SD, Silverwood IP, Khan AL, et al., 2014, Highly Selective Separation of Carbon Dioxide from Nitrogen and Methane by Nitrile/Glycol-Difunctionalized Ionic Liquids in Supported Ionic Liquid Membranes (SILMs), JOURNAL OF PHYSICAL CHEMISTRY B, Vol: 118, Pages: 7440-7449, ISSN: 1520-6106
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- Citations: 36
Wray P, Li J, Li LQ, et al., 2014, Combined Study of Biphasic and Zero-Order Release Formulations with Dissolution Tests and ATR-FTIR Spectroscopic Imaging, JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 103, Pages: 1995-2004, ISSN: 0022-3549
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- Citations: 8
Woodward RT, Stevens LA, Dawson R, et al., 2014, Swellable, Water- and Acid-Tolerant Polymer Sponges for Chemoselective Carbon Dioxide Capture, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 136, Pages: 9028-9035, ISSN: 0002-7863
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- Citations: 187
Gabrienko AA, Subramani V, Martyanov ON, et al., 2014, Correlation between Asphaltene Stability in n-Heptane and Crude Oil Composition Revealed with In Situ Chemical Imaging, ADSORPTION SCIENCE & TECHNOLOGY, Vol: 32, Pages: 243-255, ISSN: 0263-6174
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