Imperial College London
Alternate

Professor Sergei Kazarian

Faculty of Engineering, Department of Chemical Engineering

Professor of Physical Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5574s.kazarian Website

 
 
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Assistant

 

Mrs Sarah Payne +44 (0)20 7594 5567

 
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Location

 

440Bone BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tiernan:2020:10.1016/j.saa.2020.118636,
author = {Tiernan, H and Byrne, B and Kazarian, SG},
doi = {10.1016/j.saa.2020.118636},
journal = {Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy},
pages = {1--11},
title = {ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals},
url = {http://dx.doi.org/10.1016/j.saa.2020.118636},
volume = {241},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is a label-free, non-destructive technique that can be applied to a vast range of biological applications, from imaging cancer tissues and live cells, to determining protein content and protein secondary structure composition. This review summarises the recent advances in applications of ATR-FTIR spectroscopy to biopharmaceuticals, the application of this technique to biosimilars, and the current uses of FTIR spectroscopy in biopharmaceutical production. We discuss the use of ATR-FTIR spectroscopic imaging to investigate biopharmaceuticals, and finally, give an outlook on the possible future developments and applications of ATR-FTIR spectroscopy and spectroscopic imaging to this field. Throughout the review comparisons will be made between FTIR spectroscopy and alternative analytical techniques, and areas will be identified where FTIR spectroscopy could perhaps offer a better alternative in future studies. This review focuses on the most recent advances in the field of using ATR-FTIR spectroscopy and spectroscopic imaging to characterise and evaluate biopharmaceuticals, both in industrial and academic research based environments.
AU  - Tiernan,H
AU  - Byrne,B
AU  - Kazarian,SG
DO  - 10.1016/j.saa.2020.118636
EP  - 11
PY  - 2020///
SN  - 1386-1425
SP  - 1
TI  - ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals
T2  - Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
UR  - http://dx.doi.org/10.1016/j.saa.2020.118636
UR  - https://www.sciencedirect.com/science/article/pii/S1386142520306156?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80536
VL  - 241
ER  -
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