I am currently a Wellcome Senior Clinical fellow and Professor of Hepatology. Following a post-doctoral fellowship at Stanford, USA I returned to the UK with an MRC Clinician Scientist award and subsequently a Wellcome Senior Clinical fellowship. My main research interests are in basic immunology and the immunology of viral hepatitis. To this end I perform basic immunological and translational research. My main immunological interest is the Natural Killer cell. These cells are a distinct lineage of lymphocytes that are involved in the anti-viral and anti-tumour immune responses. They are lymphocytes of the innate immune system, but can influence downstream adaptive immune responses. Their functions are controlled by an array of cell surface receptors of which the receptors for MHC class I, the killer cell immunoglobulin-like receptors (KIR) and NKG2 receptors, form a key component. Interestingly the KIR exhibit substantial population diversity, which is thought to be due to pathogen-mediated selection. In the context of our previous observations we have recently shown that specific combinations of these receptors are beneficial to the outcome of hepatitis C virus infection (Khakoo et al Science 2004 305:872-4). My research is now focused on understanding how this protection is obtained and the broader relevance of inhibitory receptors to the NK anti-viral immune response. Our studies involve immunogenetics, functional and biochemical approaches to the problem. In order to pursue these goals we have collaborative grants with Dr Christopher Walker (Columbus, Ohio) and Dr N Shoukry (CHUM, Montreal). I am always interested to hear from enthusiastic researchers interested in pursuing research in out general area.
Khakoo SI, Jamil KM, Cheent KS, 2012, NK receptors: it's all in the name, Gut, Vol:61, ISSN:0017-5749, Pages:325-326
et al., 2011, A Polymorphism in IL28B Distinguishes Exposed, Uninfected Individuals From Spontaneous Resolvers of HCV Infection, Gastroenterology, Vol:141, ISSN:0016-5085, Pages:320-U419
Cheent K, Khakoo SI, 2011, Natural killer cells and hepatitis C: action and reaction, Gut, Vol:60, ISSN:0017-5749, Pages:268-278
Jamil KM, Khakoo SI, 2011, KIR/HLA Interactions and Pathogen Immunity, Journal of Biomedicine and Biotechnology, ISSN:1110-7243
et al., 2010, Effects of MHC class I peptides on KIR2DL3 clustering and signalling, Annual Congress of the British-Society-for-Immunology, WILEY-BLACKWELL PUBLISHING, INC, Pages:134-134, ISSN:0019-2805