Imperial College London
Professor Salim Khakoo

ProfessorSalimKhakoo

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 9024s.khakoo

 
 
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Location

 

HepatologySt Marys Multiple BuildingsSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

46 results found

Khakoo SI, Jamil KM, Cheent KS, 2012, NK receptors: it's all in the name, GUT, Vol: 61, Pages: 325-326, ISSN: 0017-5749

Journal article

Knapp S, Warshow U, Ho KMA, Hegazy D, Little A-M, Fowell A, Alexander G, Thursz M, Cramp M, Khakoo SIet al., 2011, A Polymorphism in IL28B Distinguishes Exposed, Uninfected Individuals From Spontaneous Resolvers of HCV Infection, GASTROENTEROLOGY, Vol: 141, Pages: 320-U419, ISSN: 0016-5085

Journal article

Cheent K, Khakoo SI, 2011, Natural killer cells and hepatitis C: action and reaction, GUT, Vol: 60, Pages: 268-278, ISSN: 0017-5749

Journal article

Jamil KM, Khakoo SI, 2011, KIR/HLA Interactions and Pathogen Immunity, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, ISSN: 1110-7243

Journal article

al Basatena N-KS, Macnamara A, Vine AM, Thio CL, Astemborski J, Usuku K, Osame M, Kirk GD, Donfield SM, Goedert JJ, Bangham CRM, Carrington M, Khakoo SI, Asquith Bet al., 2010, KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 148-148, ISSN: 0019-2805

Conference paper

Borhis G, Purbhoo M, Ahmed PS, Fadda L, Davis DM, Khakoo SIet al., 2010, Effects of MHC class I peptides on KIR2DL3 clustering and signalling, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 134-134, ISSN: 0019-2805

Conference paper

Pelletier S, Drouin C, Bedard N, Khakoo SI, Bruneau J, Shoukry NHet al., 2010, Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses, JOURNAL OF HEPATOLOGY, Vol: 53, Pages: 805-816, ISSN: 0168-8278

Journal article

Harrison RJ, Ettorre A, Little A-M, Khakoo SIet al., 2010, Association of NKG2A with treatment for chronic hepatitis C virus infection, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 161, Pages: 306-314, ISSN: 0009-9104

Journal article

Fadda L, Borhis G, Ahmed P, Cheent K, Pageon SV, Cazaly A, Stathopoulos S, Middleton D, Mulder A, Claas FHJ, Elliott T, Davis DM, Purbhoo MA, Khakoo SIet al., 2010, Peptide antagonism as a mechanism for NK cell activation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 10160-10165, ISSN: 0027-8424

Journal article

Amadei B, Urbani S, Cazaly A, Fisicaro P, Zerbini A, Ahmed P, Missale G, Ferrari C, Khakoo SIet al., 2010, Activation of Natural Killer Cells During Acute Infection With Hepatitis C Virus, GASTROENTEROLOGY, Vol: 138, Pages: 1536-1545, ISSN: 0016-5085

Journal article

Knapp S, Warshow U, Hegazy D, Brackenbury L, Guha IN, Fowell A, Little AM, Alexander GJ, WMC R, Cramp ME, Khakoo SIet al., 2010, Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus, Hepatology 2010 Apr 51(4), Pages: 1168-1175

Natural killer cells are a key component in the immune control of viral infections. Their functions are controlled by inhibitory receptors for major histocompatability complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIR). KIR2DL3 in combination with its cognate human leukocyte antigen (HLA)-C ligand has been shown to be associated with spontaneous resolution of viremia following hepatitis C virus (HCV) infection. In order to determine if this gene combination is advantageous across all potential outcomes following HCV exposure, we studied individuals with apparent resistance to HCV infection who remain seronegative and aviremic despite long-term injection drug use and also individuals chronically infected with HCV who successfully clear HCV with treatment. Homozygosity for KIR2DL3 in combination with group 1 HLA-C allotypes was more frequent in exposed seronegative aviremic individuals as compared to those with chronic HCV (25.0% versus 9.7%, P = 0.003, odds ratio [OR] = 3.1, 95% confidence interval [CI] = 1.3-7.1) in a model similar to that found for those spontaneously resolving HCV. In individuals undergoing treatment for HCV, those with KIR2DL3 and group 1 HLA-C were more likely to make a sustained virological response (SVR) (P = 0.013, OR = 2.3, 95% CI = 1.1-4.5). KIR and HLA-C protection in both treatment response and spontaneously resolving HCV was validated at the allelic level, in which KIR2DL3-HLA-Cw*03 was associated with SVR (P = 0.004, OR = 3.4, 95% CI = 1.5-8.7) and KIR2DL3/KIR2DL3-HLA-Cw*03 was associated with spontaneous resolution of HCV infection (P = 0.01, OR = 2.3, 95% CI = 1.2-4.4). Conclusion: KIR and HLA-C genes are consistently beneficial determinants in the outcome of HCV infection. This advantage extends to the allelic level for both gene families.

Journal article

Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'hUigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington Met al., 2009, Genetic variation in IL28B and spontaneous clearance of hepatitis C virus, NATURE, Vol: 461, Pages: 798-U52, ISSN: 0028-0836

Journal article

Cheent K, Khakoo SI, 2009, Natural killer cells: integrating diversity with function, IMMUNOLOGY, Vol: 126, Pages: 449-457, ISSN: 0019-2805

Journal article

Ettorre A, Khakoo SI, 2008, Single chain fragments recognising specific subsets of receptors expressed on Natural Killer cells: from selection and characterisation to potential therapeutic applications, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 72-72, ISSN: 0019-2805

Conference paper

Khakoo S, Arkwright P, Carter R, Cazaly A, Harrison R, Mant A, Taylor N, Cant AJ, Gadola S, Elliott TJ, Williams APet al., 2008, Bone marrow transplantation for MHC class I deficiency dissociates NK cell repertoire formation from self-tolerance, 13th European-Soc-for-Immunodeficiencies/10th Int-Patient-Org-for-Primary-Immunodeficiencies/8th Int-Nursing-Group-for-Immunodeficiencies Meeting, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 207-207, ISSN: 0009-9104

Conference paper

Goverdhan SV, Khakoo SI, Gaston H, Chen X, Lotery AJet al., 2008, Age-Related Macular Degeneration Is Associated with the HLA-Cw*0701 Genotype and the Natural Killer Cell Receptor AA Haplotype, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 49, Pages: 5077-5082, ISSN: 0146-0404

Journal article

Harrison RJ, Brackenbury LS, Little A-M, Khakoo SIet al., 2008, NATURAL KILLER CELL PHENOTYPES IN CHRONIC HEPATITIS C INFECTION: CORRELATION WITH GENETICS AND THE OUTCOME OF TREATMENT, 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 785A-785A, ISSN: 0270-9139

Conference paper

Martinez-Borra J, Khakoo SI, 2008, Speed and selection in the evolution of killer-cell immunoglobulin-like receptors, INTERNATIONAL JOURNAL OF IMMUNOGENETICS, Vol: 35, Pages: 89-96, ISSN: 1744-3121

Journal article

De Silva AN, Muddu AK, Iredale JP, Sheron N, Khakoo SI, Pelosi Eet al., 2008, Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: Time for routine testing?., JOURNAL OF MEDICAL VIROLOGY, Vol: 80, Pages: 283-288, ISSN: 0146-6615

Journal article

Khakoo SI, Carrington M, 2006, KIR and disease: a model system or system of models?, IMMUNOLOGICAL REVIEWS, Vol: 214, Pages: 186-201, ISSN: 0105-2896

Journal article

Brooks CR, Elliott T, Parham P, Khakoo SIet al., 2006, The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells, JOURNAL OF IMMUNOLOGY, Vol: 176, Pages: 1141-1147, ISSN: 0022-1767

Journal article

Williams AP, Bateman AR, Khakoo SI, 2005, Hanging in the balance - KIR and their role in disease, MOLECULAR INTERVENTIONS, Vol: 5, Pages: 226-240, ISSN: 1534-0384

Journal article

Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao XJ, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, Cox S, Little AM, Alexander GJ, Cramp ME, O'Brien SJ, Rosenberg WMC, Thomas DL, Carrington Met al., 2004, HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection, SCIENCE, Vol: 305, Pages: 872-874, ISSN: 0036-8075

Journal article

Jones JIW, Khakoo SI, British Society for Gastroenterology, 2003, Meeting report of the British Society for Gastroenterology meeting, March 2003., Gut, Vol: 52, Pages: 1383-1384, ISSN: 0017-5749

Journal article

Khakoo SI, Brooks CR, 2003, MHC class I receptors on natural killer cells: on with the old and in with the new, CLINICAL SCIENCE, Vol: 105, Pages: 127-140, ISSN: 0143-5221

Journal article

Brooks CR, Rosenberg WM, Khakoo SI, 2003, Killer cell immunoglobulin-like receptor (KIR) mRNA expression in natural killer (NK) cells, Annual Meeting of the British-Association-for-the-Study-of-the-Liver, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0017-5749

Conference paper

Khakoo SI, Brooks CR, Howell M, Alexander GJ, Rosenberg WMet al., 2003, Natural killer (NK) cell receptor genotypes in hepatitis C virus infection, Annual Meeting of the British-Association-for-the-Study-of-the-Liver, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0017-5749

Conference paper

Khakoo SI, Geller R, Shin S, Jenkins JA, Parham Pet al., 2002, The DO domain of KIR3D acts as a major histocompatibility complex class I binding enhancer, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 196, Pages: 911-921, ISSN: 0022-1007

Journal article

Khakoo SI, Brooks CL, Alexander G, Howell M, Rosenberg Wet al., 2002, Natural killer (NK) cell receptor genotypes in hepatitis C virus infection., 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: W B SAUNDERS CO, Pages: 275A-275A, ISSN: 0270-9139

Conference paper

Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham Pet al., 2002, Conservation and variation in human and common chimpanzee CD94 and NKG2 genes, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 240-252, ISSN: 0022-1767

Journal article

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