Publications
46 results found
Khakoo SI, Jamil KM, Cheent KS, 2012, NK receptors: it's all in the name, GUT, Vol: 61, Pages: 325-326, ISSN: 0017-5749
Knapp S, Warshow U, Ho KMA, et al., 2011, A Polymorphism in IL28B Distinguishes Exposed, Uninfected Individuals From Spontaneous Resolvers of HCV Infection, GASTROENTEROLOGY, Vol: 141, Pages: 320-U419, ISSN: 0016-5085
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- Citations: 67
Cheent K, Khakoo SI, 2011, Natural killer cells and hepatitis C: action and reaction, GUT, Vol: 60, Pages: 268-278, ISSN: 0017-5749
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- Citations: 77
Jamil KM, Khakoo SI, 2011, KIR/HLA Interactions and Pathogen Immunity, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, ISSN: 1110-7243
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- Citations: 75
al Basatena N-KS, Macnamara A, Vine AM, et al., 2010, KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 148-148, ISSN: 0019-2805
Borhis G, Purbhoo M, Ahmed PS, et al., 2010, Effects of MHC class I peptides on KIR2DL3 clustering and signalling, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 134-134, ISSN: 0019-2805
Pelletier S, Drouin C, Bedard N, et al., 2010, Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses, JOURNAL OF HEPATOLOGY, Vol: 53, Pages: 805-816, ISSN: 0168-8278
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- Citations: 84
Harrison RJ, Ettorre A, Little A-M, et al., 2010, Association of NKG2A with treatment for chronic hepatitis C virus infection, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 161, Pages: 306-314, ISSN: 0009-9104
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- Citations: 31
Fadda L, Borhis G, Ahmed P, et al., 2010, Peptide antagonism as a mechanism for NK cell activation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 107, Pages: 10160-10165, ISSN: 0027-8424
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- Citations: 123
Amadei B, Urbani S, Cazaly A, et al., 2010, Activation of Natural Killer Cells During Acute Infection With Hepatitis C Virus, GASTROENTEROLOGY, Vol: 138, Pages: 1536-1545, ISSN: 0016-5085
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- Citations: 133
Knapp S, Warshow U, Hegazy D, et al., 2010, Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus, Hepatology 2010 Apr 51(4), Pages: 1168-1175
Natural killer cells are a key component in the immune control of viral infections. Their functions are controlled by inhibitory receptors for major histocompatability complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIR). KIR2DL3 in combination with its cognate human leukocyte antigen (HLA)-C ligand has been shown to be associated with spontaneous resolution of viremia following hepatitis C virus (HCV) infection. In order to determine if this gene combination is advantageous across all potential outcomes following HCV exposure, we studied individuals with apparent resistance to HCV infection who remain seronegative and aviremic despite long-term injection drug use and also individuals chronically infected with HCV who successfully clear HCV with treatment. Homozygosity for KIR2DL3 in combination with group 1 HLA-C allotypes was more frequent in exposed seronegative aviremic individuals as compared to those with chronic HCV (25.0% versus 9.7%, P = 0.003, odds ratio [OR] = 3.1, 95% confidence interval [CI] = 1.3-7.1) in a model similar to that found for those spontaneously resolving HCV. In individuals undergoing treatment for HCV, those with KIR2DL3 and group 1 HLA-C were more likely to make a sustained virological response (SVR) (P = 0.013, OR = 2.3, 95% CI = 1.1-4.5). KIR and HLA-C protection in both treatment response and spontaneously resolving HCV was validated at the allelic level, in which KIR2DL3-HLA-Cw*03 was associated with SVR (P = 0.004, OR = 3.4, 95% CI = 1.5-8.7) and KIR2DL3/KIR2DL3-HLA-Cw*03 was associated with spontaneous resolution of HCV infection (P = 0.01, OR = 2.3, 95% CI = 1.2-4.4). Conclusion: KIR and HLA-C genes are consistently beneficial determinants in the outcome of HCV infection. This advantage extends to the allelic level for both gene families.
Thomas DL, Thio CL, Martin MP, et al., 2009, Genetic variation in IL28B and spontaneous clearance of hepatitis C virus, NATURE, Vol: 461, Pages: 798-U52, ISSN: 0028-0836
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- Citations: 1685
Cheent K, Khakoo SI, 2009, Natural killer cells: integrating diversity with function, IMMUNOLOGY, Vol: 126, Pages: 449-457, ISSN: 0019-2805
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- Citations: 95
Ettorre A, Khakoo SI, 2008, Single chain fragments recognising specific subsets of receptors expressed on Natural Killer cells: from selection and characterisation to potential therapeutic applications, Annual Congress of the British-Society-of-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 72-72, ISSN: 0019-2805
Khakoo S, Arkwright P, Carter R, et al., 2008, Bone marrow transplantation for MHC class I deficiency dissociates NK cell repertoire formation from self-tolerance, 13th European-Soc-for-Immunodeficiencies/10th Int-Patient-Org-for-Primary-Immunodeficiencies/8th Int-Nursing-Group-for-Immunodeficiencies Meeting, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 207-207, ISSN: 0009-9104
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- Citations: 1
Goverdhan SV, Khakoo SI, Gaston H, et al., 2008, Age-Related Macular Degeneration Is Associated with the HLA-Cw*0701 Genotype and the Natural Killer Cell Receptor AA Haplotype, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 49, Pages: 5077-5082, ISSN: 0146-0404
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- Citations: 16
Harrison RJ, Brackenbury LS, Little A-M, et al., 2008, NATURAL KILLER CELL PHENOTYPES IN CHRONIC HEPATITIS C INFECTION: CORRELATION WITH GENETICS AND THE OUTCOME OF TREATMENT, 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases, Publisher: JOHN WILEY & SONS INC, Pages: 785A-785A, ISSN: 0270-9139
Martinez-Borra J, Khakoo SI, 2008, Speed and selection in the evolution of killer-cell immunoglobulin-like receptors, INTERNATIONAL JOURNAL OF IMMUNOGENETICS, Vol: 35, Pages: 89-96, ISSN: 1744-3121
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- Citations: 14
De Silva AN, Muddu AK, Iredale JP, et al., 2008, Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: Time for routine testing?., JOURNAL OF MEDICAL VIROLOGY, Vol: 80, Pages: 283-288, ISSN: 0146-6615
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- Citations: 26
Khakoo SI, Carrington M, 2006, KIR and disease: a model system or system of models?, IMMUNOLOGICAL REVIEWS, Vol: 214, Pages: 186-201, ISSN: 0105-2896
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- Citations: 223
Brooks CR, Elliott T, Parham P, et al., 2006, The inhibitory receptor NKG2A determines lysis of vaccinia virus-infected autologous targets by NK cells, JOURNAL OF IMMUNOLOGY, Vol: 176, Pages: 1141-1147, ISSN: 0022-1767
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- Citations: 27
Williams AP, Bateman AR, Khakoo SI, 2005, Hanging in the balance - KIR and their role in disease, MOLECULAR INTERVENTIONS, Vol: 5, Pages: 226-240, ISSN: 1534-0384
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- Citations: 80
Khakoo SI, Thio CL, Martin MP, et al., 2004, HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection, SCIENCE, Vol: 305, Pages: 872-874, ISSN: 0036-8075
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- Citations: 915
Jones JIW, Khakoo SI, British Society for Gastroenterology, 2003, Meeting report of the British Society for Gastroenterology meeting, March 2003., Gut, Vol: 52, Pages: 1383-1384, ISSN: 0017-5749
Khakoo SI, Brooks CR, 2003, MHC class I receptors on natural killer cells: on with the old and in with the new, CLINICAL SCIENCE, Vol: 105, Pages: 127-140, ISSN: 0143-5221
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- Citations: 4
Brooks CR, Rosenberg WM, Khakoo SI, 2003, Killer cell immunoglobulin-like receptor (KIR) mRNA expression in natural killer (NK) cells, Annual Meeting of the British-Association-for-the-Study-of-the-Liver, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0017-5749
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- Citations: 1
Khakoo SI, Brooks CR, Howell M, et al., 2003, Natural killer (NK) cell receptor genotypes in hepatitis C virus infection, Annual Meeting of the British-Association-for-the-Study-of-the-Liver, Publisher: BRITISH MED JOURNAL PUBL GROUP, ISSN: 0017-5749
Khakoo SI, Geller R, Shin S, et al., 2002, The DO domain of KIR3D acts as a major histocompatibility complex class I binding enhancer, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 196, Pages: 911-921, ISSN: 0022-1007
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- Citations: 59
Khakoo SI, Brooks CL, Alexander G, et al., 2002, Natural killer (NK) cell receptor genotypes in hepatitis C virus infection., 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: W B SAUNDERS CO, Pages: 275A-275A, ISSN: 0270-9139
Shum BP, Flodin LR, Muir DG, et al., 2002, Conservation and variation in human and common chimpanzee CD94 and NKG2 genes, JOURNAL OF IMMUNOLOGY, Vol: 168, Pages: 240-252, ISSN: 0022-1767
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- Citations: 76
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