Publications
434 results found
Panoskaltsis N, Knight SC, Reid CDL, 2001, Characterisation of dendritic cells matured with polarising cytokines., BLOOD, Vol: 98, Pages: 38B-38B, ISSN: 0006-4971
Panoskaltsis N, Knight SC, Reid CDL, 2001, A simple whole blood assay for the evaluation of immune activity in acute myelogenous leukemia (AML)., BLOOD, Vol: 98, Pages: 112A-112A, ISSN: 0006-4971
Van den Bogaerde J, Kamm MA, Knight SC, 2001, Immune sensitization to food, yeast and bacteria in Crohn's disease, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 15, Pages: 1647-1653, ISSN: 0269-2813
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- Citations: 33
Bell SJ, Rigby R, English N, et al., 2001, Migration and maturation of human colonic dendritic cells, JOURNAL OF IMMUNOLOGY, Vol: 166, Pages: 4958-4967, ISSN: 0022-1767
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- Citations: 138
Patterson S, English NR, Longhurst H, et al., 2001, Relationship between V3 sequences of HIV type 1 from plasma, T cells, and dendritic cells suggests that plasma virus may arise from different cell sources, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 17, Pages: 179-184, ISSN: 0889-2229
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- Citations: 3
Almand B, Clark JI, Nikitina E, et al., 2001, Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer, JOURNAL OF IMMUNOLOGY, Vol: 166, Pages: 678-689, ISSN: 0022-1767
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- Citations: 1016
Knight SC, 2001, Dendritic cells: An overview, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 31, Pages: 164-164, ISSN: 0954-7894
Stagg AJ, Burke F, Hill S, et al., 2001, Isolation of dendritic cells from animal tissues: Isolation of mouse spleen dendritic cells, Methods in Molecular Medicine, Editors: Robinson, Stagg J, New Jersey, USA, Publisher: Humana Press, Pages: 9-22
Knight SC, Burke F, Bedford PA, 2001, Interactions between dendritic cells, Advances in Experimental Medicine and Biology, Pages: 103-109
Knight SC, 2001, Forward, Methods in Molecular Medicine: Dendritic Cell Protocols, Editors: Robinson, Stagg, Publisher: Humana Press
Knight SC, Bedford PA, 2001, Dendritic cell/dendritic cell interaction, Dendritic Cells: Biology and Clinical Applications, Editors: Thompson, Lotze T, London, Publisher: Academic Press, Pages: 333-343, ISBN: 9780124558519
Stagg AJ, Burke F, Hill S, et al., 2001, Isolation of mouse spleen dendritic cells., Methods Mol Med, Vol: 64, Pages: 9-22, ISSN: 1543-1894
It is now over 20 years since dendritic cells (DC) were first identified in and isolated from the spleens of mice (1,2) and they continue to be a much-studied population. Only a small proportion of spleen cells are DC, but the large size of the organ means that useful numbers of DC can still be purified. In recent years the ability to grow cells with the phenotypic and functional properties of DC from bone marrow progenitors has opened new avenues of research. However, the relationship of cells grown in this way to DC populations in vivo is unknown and the need remains to study DC present in tissues.
Knight SC, Burke F, Bedford PA, 2001, Interactions between dendritic cells, PROGRESS IN BASIC AND CLINICAL IMMUNOLOGY, Vol: 495, Pages: 103-109, ISSN: 0065-2598
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- Citations: 1
Panoskaltsis N, Knight SC, Reid CDL, 2000, Differential cytokine profiles of leukaemic blasts and leukaemic dendritic cells: implications for immunotherapy, Blood, Vol: 96, ISSN: 0006-4971
Dendritic cells (DCs) generated from leukaemic blasts are being evaluated for use in the immunotherapy of leukaemia. DCs can be cultured from most subtypes of AML blasts in approximately 50-75% of samples. These leukaemic DCs (LDCs) are derived from the leukaemic clone and are similar to mature DCs in their expression of surface markers and in their capacity to stimulate lymphocytes. However, stimulation of cytotoxicity against the original AML blasts using T cells expanded with LDCs has had limited success. These cytotoxicity results may be partly explained by the different methods used to generate the LDCs, in particular, the cytokines used in the culture. AML bone marrow mononuclear cells were cultured in serum-free medium for 4-5 and 13-14 days in the presence of granulocytemacrophage colony stimulating factor and stem cell factor and supplemented with one of the following cytokines: tumour necrosis factor(TNF)-a, interleukin(IL)-4, IL-12, or flt-3 ligand ( FL). Cells were evaluated by flow cytometry for DC surface markers, CD80, CD86, CD 1 a, CD40, CD 11 c, and HLA-DR, as well as for intracellular cytokines IL-4, IL-10, IL-12, and interferon(IFN)-y in the presence and absence of calcium ionophore, and the vesiculartransport inhibitor, monensin. Prior to culture, the AML blasts were skewed towards a type 2 cytokine profile, and in particular, showed IL-10 production out of proportion to the other cytokines. After culture, the cytokine profile of the LDC was influenced differentially, depending on the cytokine cocktails used. Exposure to TNF-a during the entire culture period, did not polarise the cells towards type 1 or type 2 cytokine production, but IL-4 caused the cultured cells to produce more IL-4. IL-12 exposure induced type 1 cytokines, namely IL-12 and IFN-y. In contrast, FL upregulated both type 1 and type 2 cytokines. Interestingly, IL-10 production by the leukaemic blasts was abrogated in all culture conditions. In one sample, although IL-4 induced mo
Panoskaltsis N, Knight SC, Reid CDL, 2000, Differential cytokine profiles of leukaemic blasts and leukaemic dendritic cells: Implications for immunotherapy., BLOOD, Vol: 96, Pages: 215B-215B, ISSN: 0006-4971
Rigby R, Stagg AJ, Bell SJ, et al., 2000, Spontaneous production of pro-inflammatory cytokines by colonic biopsies is altered by treatment of Crohn's disease patients with anti-TNFα antibody., GASTROENTEROLOGY, Vol: 118, Pages: A108-A108, ISSN: 0016-5085
Rowlands DE, Mann S, Forbes A, et al., 2000, CD8+lamina propria lymphocytes have an increased potential to produce interferon-gamma (IFNΓ) in patients with ulcerative colitis., GASTROENTEROLOGY, Vol: 118, Pages: A114-A114, ISSN: 0016-5085
Bell SJ, Rigby R, Kamm MA, et al., 2000, Co-stimulatory molecule expression on gut dendritic cells (DC) is upregulated in inflamed tissue from Crohn's disease - A possible early and central step in driving T cell activation., GASTROENTEROLOGY, Vol: 118, Pages: A813-A813, ISSN: 0016-5085
Day R, Mitchell T, Knight S, et al., 2000, Suppression of epithelial syndecan-1 expression by tumor necrosis factor-A., Publisher: W B SAUNDERS CO, Pages: A806-A806, ISSN: 0016-5085
Stagg AJ, Bell SJ, Rigby R, et al., 2000, Treatment with anti-TNFA antibody reduces expression of CD40 on lamina propria dendritic cells - An early and central step in reducing T cell driven inflammation., GASTROENTEROLOGY, Vol: 118, Pages: A353-A353, ISSN: 0016-5085
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- Citations: 4
Rowlands DE, Forbes A, Knight S, et al., 2000, Migrating colonic lamina propria lymphocytes demonstrate increased T cell activation and cytokine production, GUT, Vol: 46, Pages: A72-A72, ISSN: 0017-5749
Rowlands DE, Forbes A, Knight SC, et al., 2000, Migrating colonic lamina propria lymphocytes demonstrate increased T cell activation and proinflammatory cytokine production., GASTROENTEROLOGY, Vol: 118, Pages: A818-A818, ISSN: 0016-5085
Knight S, 1999, Dendritic cells in retroviral infection, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 15, Pages: 1605-1605, ISSN: 0889-2229
Bedford P, Garner K, Knight SC, 1999, MHC class II molecules transferred between allogeneic dendritic cells stimulate primary mixed leukocyte reactions, INTERNATIONAL IMMUNOLOGY, Vol: 11, Pages: 1739-1744, ISSN: 0953-8178
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- Citations: 64
Robinson SP, Patterson S, English N, et al., 1999, Human peripheral blood contains two distinct lineages of dendritic cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 29, Pages: 2769-2778, ISSN: 0014-2980
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- Citations: 304
Wang H, English NJ, Reid CDL, et al., 1999, Role of β-chemokines in HIV-1 infection of dendritic cells maturing from CD34<SUP>+</SUP> stem cells, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 21, Pages: 179-188, ISSN: 1077-9450
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- Citations: 8
Kelleher P, Maroof A, Knight SC, 1999, Retrovirally induced switch from production of IL-12 to IL-4 in dendritic cells, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 29, Pages: 2309-2318, ISSN: 0014-2980
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- Citations: 42
Konecny P, Stagg AJ, Jebbari H, et al., 1999, Murine dendritic cells internalize <i>Leishmania major</i> promastigotes, produce IL-12 p40 and stimulate primary T cell proliferation <i>in vitro</i>, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 29, Pages: 1803-1811, ISSN: 0014-2980
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- Citations: 97
Patterson S, Robinson SP, English NR, et al., 1999, Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1, IMMUNOLOGY LETTERS, Vol: 66, Pages: 111-116, ISSN: 0165-2478
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- Citations: 22
Fisher GM, Iqball S, Knight SC, 1999, Gene expression during differentiation of human dendritic cells from cord blood CD34 stem cells, CYTOKINE, Vol: 11, Pages: 111-117, ISSN: 1043-4666
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- Citations: 13
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