Publications
434 results found
Lee GH, Askari A, Malietzis G, et al., 2014, The Role of CD40 Expression in Dendritic Cells in Cancer Biology; A Systematic Review, CURRENT CANCER DRUG TARGETS, Vol: 14, Pages: 610-620, ISSN: 1568-0096
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- Citations: 17
Mann ER, Bernardo D, English NR, et al., 2013, Compartment specific tolerance and immunity in the human gut; properties and functions of dendritic cells and macrophages in the colon versus the ileum, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 169-169, ISSN: 0019-2805
Bernardo D, Montalvillo E, Bayiroglu F, et al., 2013, Increased cytokine milieu, IgA, intraepithelial lymphocytes and CD103<SUP>-</SUP> mature DC in the human right colon compared with its left paired counterpart, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 39-39, ISSN: 0019-2805
Rahbour G, Al-Hassi HO, Hart AL, et al., 2013, Prospective study to assess tumour necrosis factor alpha in non-inflammatory bowel disease enterocutaneous fistula., Int J Surg, Vol: 11, Pages: 589-590
Al-Hassi HO, Lee G, Malietzis G, et al., 2013, Activation and maturation status of dendritic cells is altered in post-operative colorectal cancer patients, European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, Publisher: ELSEVIER SCI LTD, Pages: S500-S500, ISSN: 0959-8049
Lee G, Malietzis G, Yssin N, et al., 2013, Increased activation and migration potential of dendritic cell in patients with colorectal cancer - the implication and future of cancer immunotherapy, European Cancer Congress 2013 - 17th ECCO / 38th ESMO / 32nd ESTRO, Publisher: ELSEVIER SCI LTD, Pages: S498-S499, ISSN: 0959-8049
You J, Dong H, Mann ER, et al., 2013, Ageing impairs the T cell response to dendritic cells, IMMUNOBIOLOGY, Vol: 218, Pages: 1077-1084, ISSN: 0171-2985
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- Citations: 15
Mann ER, You J, Horneffer-van der Sluis V, et al., 2013, Dysregulated circulating dendritic cell function in ulcerative colitis is partially restored by probiotic strain lactobacillus casei shirota, Mediators of Inflammation, Vol: 2013, Pages: 1-12, ISSN: 0962-9351
Background. Dendritic cells regulate immune responses to microbial products and play a key role in ulcerative colitis (UC) pathology. We determined the immunomodulatory effects of probiotic strain Lactobacillus casei Shirota (LcS) on human DC from healthy controls and active UC patients. Methods. Human blood DC from healthy controls (control-DC) and UC patients (UC-DC) were conditioned with heat-killed LcS and used to stimulate allogeneic T cells in a 5-day mixed leucocyte reaction. Results. UC-DC displayed a reduced stimulatory capacity for T cells () and enhanced expression of skin-homing markers CLA and CCR4 on stimulated T cells () that were negative for gut-homing marker 7. LcS treatment restored the stimulatory capacity of UC-DC, reflecting that of control-DC. LcS treatment conditioned control-DC to induce CLA on T cells in conjunction with 7, generating a multihoming profile, but had no effects on UC-DC. Finally, LcS treatment enhanced DC ability to induce TGF production by T cells in controls but not UC patients. Conclusions. We demonstrate a systemic, dysregulated DC function in UC that may account for the propensity of UC patients to develop cutaneous manifestations. LcS has multifunctional immunoregulatory activities depending on the inflammatory state; therapeutic effects reported in UC may be due to promotion of homeostasis.
Yassin NA, Al-Hassi HO, Lee GH, et al., 2013, Increased Gut Homing (B7) on Dendritic cells in Fistulating Perianal Crohn’s Disease, ICMI
Al-Hassi HO, Bernardo D, Murugananthan AU, et al., 2013, A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease, Mucosal Immunology, Vol: 6, Pages: 751-761, ISSN: 1933-0219
Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3beta in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation.
Yassin NA, Al-Hassi HO, Lee GH, et al., 2013, The Aetiology of Crohn’s and Idiopathic Anal Fistulae - Are There Any Differences in the Dendritic Cells Homing Profile?, ACPGBI
Yassin NA, Al-Hassi OH, Lee GH, et al., 2013, The Immune Cell Activation and Homing Profile of Dendritic Cells in Fistulating Perianal Crohn's Disease, DDW
Rahbour G, Al-Hassi HO, Hart AL, et al., 2013, Tumour necrosis factor alpha in non-inflammatory bowel disease enterocutaneous fistulas prospective study, Joint Meeting of the Section-of-Surgery of the Royal-Society-of-Medicine / Annual Meeting of the Society-of-Academic-and-Research-Surgery, Publisher: WILEY-BLACKWELL, Pages: 37-37, ISSN: 0007-1323
Rigby RJ, Thagia I, Pattisson C, et al., 2013, Intestine mucosal IL-22 is reduced following oral probiotic administration: implications on epithelial barrier repair, Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Yassin NA, Al-Hassi H, Lee GH, et al., 2013, The aetiology, immune activation and homing profile of dendritic cells in fistulating perianal Crohn's disease, European Crohn's and Colitis Organisation
Mann ER, Landy J, Bernardo D, et al., 2013, Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men, Immunology Letters
Xiang M, Ai-Hassi HO, Knight SC, et al., 2013, Delta-5 and delta-6 desaturases in peripheral blood mononuclear cells, β7<SUP>+</SUP> and β7<SUP>-</SUP> lymphocytes in healthy controls and patients with Crohn's disease, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 72, Pages: E27-E27, ISSN: 0029-6651
You J, Dong H, Mann ER, et al., 2013, Probiotic modulation of dendritic cell function is influenced by ageing, PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 72, Pages: E264-E264, ISSN: 0029-6651
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- Citations: 1
Peake STC, Bernardo D, Mann ER, et al., 2013, Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?, J Crohns Colitis
Bernardo D, Mann ER, Al-Hassi HO, et al., 2013, Lost therapeutic potential of monocyte-derived DC through lost tissue homing; stable restoration of gut specificity with retinoic acid, Clinical Experimental Immunology
Sánchez B, Margoles A, Bernardo D, et al., 2012, Peptido secretado por lactobacillus plantarum con funcion inmunomoduladora, PCT/ES2012/070643
La presente invencion, que describe el uso de un peptido secretado por unlactobacilo en inmunoterapia humana, puede encuadrarse tanto en el sector de latecnologia de los alimentos como en el de la medicina. Se trata de la secuencia deaminoacidos (peptido ST), que podria ser utilizado en la inmunoterapia de ciertasenfermedades inflamatorias, como la enfermedad inflamatoria intestinal (EII; divididaen Enfermedad de Chron, Colitis Ulcerosa y Pouchitis) y en otras patologias dondela tolerancia oral se encuentra comprometida (como en el caso de la enfermedadceliaca frente al gluten de la dieta). La via de administracion podria ser su inclusionen un alimento funcional o via maduracion dirigida de celulas dendriticas del donante(vacunas de celulas dendriticas).
Mann ER, McCarthy NE, Peake STC, et al., 2012, Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 170, Pages: 122-130, ISSN: 0009-9104
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- Citations: 24
Rahbour G, Al-Hassi HO, Hart AL, et al., 2012, Tumour necrosis factor alpha in non-inflammatory bowel disease enterocutaneous fistulas prospective study, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 536-537, ISSN: 0019-2805
Mann E, Peake STC, Bernardo D, et al., 2012, Tissue specific, homeostatic properties of human gut dendritic cells: small bowel versus colon, European Congress of Immunology, Publisher: WILEY-BLACKWELL, Pages: 139-139, ISSN: 0019-2805
Murugananthan AU, Bernardo DO, Tozer P, et al., 2012, CLINICAL RISK FACTORS FOR CROHN'S DISEASE POSTOPERATIVE RECURRENCE ARE REFLECTED IN ALTERATIONS IN MUCOSALLY ADHERENT MICROBIOTA AT SURGICAL RESECTION, GUT, Vol: 61, Pages: A168-A168, ISSN: 0017-5749
Landy J, Al-Hassi HO, Peake ST, et al., 2012, INAPPROPRIATE INFLAMMATORY RESPONSES IN THE ILEUM OF ULCERATIVE COLITIS PATIENTS, GUT, Vol: 61, Pages: A222-A222, ISSN: 0017-5749
Murugananthan AU, Bernardo DO, Mann ER, et al., 2012, ILEAL AND COLONIC MUCOSAL DENDRITIC CELL CYTOKINE PROFILES DIFFER AT REST AND AFTER IN VITRO BACTERIA AND PRO-BIOTIC CHALLENGE IN POSTOPERATIVE CROHN'S DISEASE PATIENTS, GUT, Vol: 61, Pages: A168-A168, ISSN: 0017-5749
Bernardo D, Sánchez B, Al-Hassi HO, et al., 2012, Microbiota/host crosstalk biomarkers: regulatory response of human intestinal dendritic cells exposed to Lactobacillus extracellular encrypted peptide, PLoS One, Vol: 5, Pages: 1-8, ISSN: 1932-6203
The human gastrointestinal tract is exposed to a huge variety of microorganisms, either commensal or pathogenic; at this site, a balance between immunity and immune tolerance is required. Intestinal dendritic cells (DCs) control the mechanisms of immune response/tolerance in the gut. In this paper we have identified a peptide (STp) secreted by Lactobacillus plantarum, characterized by the abundance of serine and threonine residues within its sequence. STp is encoded in one of the main extracellular proteins produced by such species, which includes some probiotic strains, and lacks cleavage sites for the major intestinal proteases. When studied in vitro, STp expanded the ongoing production of regulatory IL-10 in human intestinal DCs from healthy controls. STp-primed DC induced an immunoregulatory cytokine profile and skin-homing profile on stimulated T-cells. Our data suggest that some of the molecular dialogue between intestinal bacteria and DCs may be mediated by immunomodulatory peptides, encoded in larger extracellular proteins, secreted by commensal bacteria. These peptides may be used for the development of nutraceutical products for patients with IBD. In addition, this kind of peptides seem to be absent in the gut of inflammatory bowel disease patients, suggesting a potential role as biomarker of gut homeostasis.
Murugananthan AU, Tozer P, Ordiz DB, et al., 2012, Clinical Risk Factors for Crohn's Disease Postoperative Recurrence are Reflected in Alterations in Mucosally Adherent Microbiota at Surgical Resection, Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S679-S679, ISSN: 0016-5085
Murugananthan AU, Tozer P, Ordiz DB, et al., 2012, Dysbiosis in Mucosally Adherent Microbiota at Surgery and in Post-Endoscopic Recurrence at 6 and 12 Months- a Longitudinal Prospective Evaluation in Crohn's Disease, Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S677-S677, ISSN: 0016-5085
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- Citations: 1
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