Imperial College London
Alternate

ProfessorStellaKnight

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Research Investigator
 
 
 
//

Contact

 

+44 (0)20 8869 3494s.knight Website

 
 
//

Assistant

 

Ms Alison Scoggins +44 (0)20 8869 3534

 
//

Location

 

7W032Northwick ParkNorthwick Park and St Marks Site

//

Summary

 

Publications

Citation

BibTex format

@article{Panoskaltsis:2021:10.1007/s00262-020-02702-9,
author = {Panoskaltsis, N and McCarthy, NE and Knight, SC},
doi = {10.1007/s00262-020-02702-9},
journal = {Cancer Immunology Immunotherapy},
pages = {1155--1160},
title = {Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm},
url = {http://dx.doi.org/10.1007/s00262-020-02702-9},
volume = {70},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - TGN1412, a superagonist monoclonal antibody targeting CD28, caused cytokine storm in six healthy volunteers in a first-in-man study in 2006. Despite clinical improvement and termination of the cytokine release syndrome within days, anemia persisted in all patients with hemoglobin reaching baseline levels as much as 6 months later. Granulocytic dysplasia continued for 20 days in association with increased expression of CD69 and IL-4, but reduced IL-10; with resolution, this profile reversed to higher IL-10 expression and counter-balanced circannual cycling of IL-4 and IL-10 thereafter over 7 months. Along with immune cell subset and cytokine correlates monitored over 2 years, these observations offer unique insights into the expected changes in myelopoiesis and natural resolution in otherwise healthy young individuals in response to acute inflammation and cytokine storm in the absence of concomitant infection or comorbidity.
AU  - Panoskaltsis,N
AU  - McCarthy,NE
AU  - Knight,SC
DO  - 10.1007/s00262-020-02702-9
EP  - 1160
PY  - 2021///
SN  - 0340-7004
SP  - 1155
TI  - Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm
T2  - Cancer Immunology Immunotherapy
UR  - http://dx.doi.org/10.1007/s00262-020-02702-9
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32862238
UR  - http://hdl.handle.net/10044/1/82332
VL  - 70
ER  -
Download