Imperial College London
Alternate

ProfessorStellaKnight

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Research Investigator
 
 
 
//

Contact

 

+44 (0)20 8869 3494s.knight Website

 
 
//

Assistant

 

Ms Alison Scoggins +44 (0)20 8869 3534

 
//

Location

 

7W032Northwick ParkNorthwick Park and St Marks Site

//

Summary

 

Publications

Citation

BibTex format

@article{McCarthy:2021:10.1007/s00262-020-02723-4,
author = {McCarthy, NE and Stagg, AJ and Price, CL and Mann, ER and Gellatly, NL and Al-Hassi, HO and Knight, SC and Panoskaltsis, N},
doi = {10.1007/s00262-020-02723-4},
journal = {Cancer Immunology Immunotherapy},
pages = {1143--1153},
title = {Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells},
url = {http://dx.doi.org/10.1007/s00262-020-02723-4},
volume = {70},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of 'gut-homing' integrin β7 on peripheral blood αβT cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2+ γδT cells in the circulation which declined over a 2-year period following drug infusion, concordant with subsiding gut symptoms. These data demonstrate that TGN1412-induced gastrointestinal symptoms were associated with dysregulation of the 'gut-homing' pool of blood αβ and γδT cells, induced directly by the antibody and/or arising from the subsequent cytokine storm.
AU  - McCarthy,NE
AU  - Stagg,AJ
AU  - Price,CL
AU  - Mann,ER
AU  - Gellatly,NL
AU  - Al-Hassi,HO
AU  - Knight,SC
AU  - Panoskaltsis,N
DO  - 10.1007/s00262-020-02723-4
EP  - 1153
PY  - 2021///
SN  - 0340-7004
SP  - 1143
TI  - Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells
T2  - Cancer Immunology Immunotherapy
UR  - http://dx.doi.org/10.1007/s00262-020-02723-4
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33048222
UR  - https://link.springer.com/article/10.1007%2Fs00262-020-02723-4
UR  - http://hdl.handle.net/10044/1/83883
VL  - 70
ER  -
Download