Imperial College London
Alternate

ProfessorStellaKnight

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 8869 3494s.knight Website

 
 
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Assistant

 

Ms Alison Scoggins +44 (0)20 8869 3534

 
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Location

 

7W032Northwick ParkNorthwick Park and St Marks Site

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Summary

 

Publications

Citation

BibTex format

@article{Malietzis:2015:10.1002/jso.23959,
author = {Malietzis, G and Lee, GH and Bernardo, D and Blakemore, AIF and Knight, SC and Moorghen, M and Al-Hassi, HO and Jenkins, JT},
doi = {10.1002/jso.23959},
journal = {Journal of Surgical Oncology},
pages = {86--92},
title = {The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer},
url = {http://dx.doi.org/10.1002/jso.23959},
volume = {112},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and ObjectivesThe host local immune response (LIR) to cancer is a determinant of cancer outcome. Regulation of this local response is largely achieved through chemokine synthesis from the tumor microenvironment such as C-Chemokine-Receptor-7 (CCR7). We examined the LIR measured as CCR7 expression, in colorectal cancers (CRC) and explored relationships with body composition (BC) and survival.MethodsA study of paraffin-embedded tissue specimens was carried out in 116 patients with non-metastatic CRC. CCR7 expression was determined by immunohistochemistry. Analysis of computer tomography scans was used to calculate BC parameters. Survival analyses and multivariate regression models were used.ResultsHigh CCR7+ cell density within the tumor stroma and at the margin was significantly associated with increased age, the presence of lymphovascular invasion, higher tumor stage, lymph node metastasis, high Klintrup-Makinen immune score, and myosteatosis. High CCR7+ cell density in the tumor margin was significantly associated with shorter disease-free (DFS) and overall survival (OS) (P < 0.001). This was also significantly associated with shorter survival in multivariate analysis (HR = 8.87; 95%CI [2.51–31.3]; P < 0.01 for OS and HR = 4.72; 95%CI (1.24–12.9); P = 0.02 for DFS).ConclusionsOur results suggest that a specific immune microenvironment may be associated with altered host's BC and tumor behavior, and that CCR7 may serve as a novel prognostic biomarker.
AU  - Malietzis,G
AU  - Lee,GH
AU  - Bernardo,D
AU  - Blakemore,AIF
AU  - Knight,SC
AU  - Moorghen,M
AU  - Al-Hassi,HO
AU  - Jenkins,JT
DO  - 10.1002/jso.23959
EP  - 92
PY  - 2015///
SN  - 1096-9098
SP  - 86
TI  - The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer
T2  - Journal of Surgical Oncology
UR  - http://dx.doi.org/10.1002/jso.23959
UR  - http://hdl.handle.net/10044/1/27620
VL  - 112
ER  -
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