Publications
144 results found
Booy R, Kroll JS, 1998, Bacterial meningitis and meningococcal infection., Curr Opin Pediatr, Vol: 10, Pages: 13-18, ISSN: 1040-8703
Now that invasive disease caused by Haemophilus influenzae type b has been largely controlled in the developed world, the principal bacterial pathogen causing meningitis in most countries is the meningococcus. Serogroup B and C strains predominate in most industrialised countries in contrast to the situation in sub-Saharan Africa, where serogroup A meningococcal disease is periodically a problem of massive epidemic proportions. This review focuses on developments in our understanding of the diagnosis and treatment of meningococcal disease, of host factors important in susceptibility to, and severity of, this infection, and on advances which may eventually lead to its prevention.
Wilks KE, Dunn KLR, Farrant JL, et al., 1998, Periplasmic superoxide dismutase in meningococcal pathogenicity, INFECTION AND IMMUNITY, Vol: 66, Pages: 213-217, ISSN: 0019-9567
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- Citations: 105
Cartwright K, Kroll S, 1997, Optimising the investigation of meningococcal disease, BRITISH MEDICAL JOURNAL, Vol: 315, Pages: 757-758, ISSN: 0959-8138
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- Citations: 20
Cash P, Argo E, Langford PR, et al., 1997, Development of a Haemophilus two-dimensional protein database, ELECTROPHORESIS, Vol: 18, Pages: 1472-1482, ISSN: 0173-0835
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- Citations: 38
Farrant JL, Sansone A, Canvin JR, et al., 1997, Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis, MOLECULAR MICROBIOLOGY, Vol: 25, Pages: 785-796, ISSN: 0950-382X
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- Citations: 109
Booy R, Kroll JS, 1997, Is Haemophilus influenzae finished?, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 40, Pages: 149-153, ISSN: 0305-7453
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- Citations: 17
DMello RA, Langford PR, Kroll JS, 1997, Role of bacterial Mn-cofactored superoxide dismutase in oxidative stress responses, nasopharyngeal colonization, and sustained bacteremia caused by Haemophilus influenzae type b, INFECTION AND IMMUNITY, Vol: 65, Pages: 2700-2706, ISSN: 0019-9567
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- Citations: 34
Langford PR, Kroll JS, 1997, Distribution, cloning, characterisation and mutagenesis of sodC, the gene encoding copper/zinc superoxide dismutase, a potential determinant of virulence, in Haemophilus ducreyi, FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, Vol: 17, Pages: 235-242, ISSN: 0928-8244
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- Citations: 9
Farrant JL, Sansone A, Canvin JR, et al., 1997, Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis, Molecular Microbiology, Vol: 25, Pages: 785-796, ISSN: 0950-382X
Copper/zinc-cofactored superoxide dismutase ([Cu,Zn]-SOD) has been found in the periplasm of many bacterial species but its biological function is unknown. Here we report the cloning and characterization of sodC, encoding [Cu,Zn]-SOD, from Salmonella typhimurium. The predicted protein sequence shows only 58% identity to Escherichia coli SodC, and from this its chromosomal location and its immediate proximity to a phage gene, sodC, in Salmonella is speculated to have been acquired by bacteriophage-mediated horizontal transfer from an unknown donor. A sodC mutant of S. typhimurium was unimpaired on aerobic growth in rich medium but showed enhanced sensitivity in vitro to the microbicidal action of superoxide. S. typhimurium, S. choleraesuis and S. dublin sodC mutants showed reduced lethality in a mouse model of oral infection and persisted in significantly lower numbers in livers and spleens after intraperitoneal infection, suggesting that [Cu,Zn]-SOD plays a role in pathogenicity, protecting Salmonella against oxygen radical-mediated host defences. There was, however, no observable difference compared with wild type in the interaction of sodC mutants with porcine pleural, mouse peritoneal or J774 macrophages in vitro, perhaps reflecting the hierarchical capacity of different macrophage lines to kill Salmonella, the most efficient overwhelming the proposed protective effect of periplasmic SOD.
Kroll S, Pollard A, Habibi P, 1997, Meningitis - A Guide for Families, London, Publisher: Publishing Solutions (UK) Ltd, ISBN: 9781901336009
Langford PR, Loynds BM, Kroll JS, 1996, Cloning and molecular characterization of Cu,Zn superoxide dismutase from Actinobacillus pleuropneumoniae, INFECTION AND IMMUNITY, Vol: 64, Pages: 5035-5041, ISSN: 0019-9567
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- Citations: 38
Gibb D, Giacomelli A, Masters J, et al., 1996, Persistence of antibody responses to Haemophilus influenzae type b polysaccharide conjugate vaccine in children with vertically acquired human immunodeficiency virus infection, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 15, Pages: 1097-1101, ISSN: 0891-3668
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- Citations: 30
Lainson FA, Thomson N, Rowe HA, et al., 1996, Occurrence of [copper, zinc]-cofactored superoxide dismutase in Pasteurella haemolytica and its serotype distribution, FEMS MICROBIOLOGY LETTERS, Vol: 142, Pages: 11-17, ISSN: 0378-1097
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- Citations: 13
Lainson FA, Thomson N, Rowe HA, et al., 1996, Occurrence of [copper, zinc]-cofactored Superoxide dismutase in<i>Pasteurella haemolytica</i>and its serotype distribution, FEMS Microbiology Letters, Vol: 142, Pages: 11-17, ISSN: 0378-1097
Kroll JS, Booy R, 1996, Haemophilus influenzae: Capsule vaccine and capsulation genetics, MOLECULAR MEDICINE TODAY, Vol: 2, Pages: 160-165, ISSN: 1357-4310
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- Citations: 11
Canvin J, Langford PR, Wilks KE, et al., 1996, Identification of sodC encoding periplasmic [Cu,Zn]-superoxide dismutase in Salmonella, FEMS MICROBIOLOGY LETTERS, Vol: 136, Pages: 215-220, ISSN: 0378-1097
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- Citations: 41
KROLL JS, LANGFORD PR, WILKS KE, et al., 1995, BACTERIAL [CU,ZN]-SUPEROXIDE DISMUTASE - PHYLOGENETICALLY DISTINCT FROM THE EUKARYOTIC ENZYME, AND NOT SO RARE AFTER ALL, MICROBIOLOGY-UK, Vol: 141, Pages: 2271-2279, ISSN: 1350-0872
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- Citations: 115
VANELDERE J, BROPHY L, LOYNDS B, et al., 1995, REGION-II OF THE HAEMOPHILUS-INFLUENZAE TYPE-B CAPSULATION LOCUS IS INVOLVED IN SEROTYPE-SPECIFIC POLYSACCHARIDE SYNTHESIS, MOLECULAR MICROBIOLOGY, Vol: 15, Pages: 107-118, ISSN: 0950-382X
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- Citations: 55
KROLL JS, LANGFORD PR, SAAH JR, et al., 1993, MOLECULAR AND GENETIC-CHARACTERIZATION OF SUPEROXIDE-DISMUTASE IN HAEMOPHILUS-INFLUENZAE TYPE-B, MOLECULAR MICROBIOLOGY, Vol: 10, Pages: 839-848, ISSN: 0950-382X
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- Citations: 21
KROLL JS, LOYNDS BM, LANGFORD PR, 1992, PALINDROMIC HAEMOPHILUS DNA UPTAKE SEQUENCES IN PRESUMED TRANSCRIPTIONAL TERMINATORS FROM HAEMOPHILUS-INFLUENZAE AND HAEMOPHILUS-PARAINFLUENZAE, GENE, Vol: 114, Pages: 151-152, ISSN: 0378-1119
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- Citations: 10
LANGFORD PR, LOYNDS BM, KROLL JS, 1992, COPPER-ZINC SUPEROXIDE-DISMUTASE IN HAEMOPHILUS SPECIES, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 138, Pages: 517-522, ISSN: 0022-1287
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- Citations: 36
LOYNDS BM, LANGFORD PR, KROLL JS, 1992, RECF IN ACTINOBACILLUS-PLEUROPNEUMONIAE, NUCLEIC ACIDS RESEARCH, Vol: 20, Pages: 615-615, ISSN: 0305-1048
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- Citations: 9
KROLL JS, LANGFORD PR, LOYNDS BM, 1991, COPPER-ZINC SUPEROXIDE-DISMUTASE OF HAEMOPHILUS-INFLUENZAE AND HAEMOPHILUS-PARAINFLUENZAE, JOURNAL OF BACTERIOLOGY, Vol: 173, Pages: 7449-7457, ISSN: 0021-9193
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- Citations: 99
LANGFORD P, WILLIAMS AE, KROLL JS, 1991, SUPEROXIDE DISMUTASES OF PATHOGENIC AND NONPATHOGENIC STREPTOCOCCUS-SUIS TYPE-2 ISOLATES, FEMS MICROBIOLOGY LETTERS, Vol: 77, Pages: 347-350, ISSN: 0378-1097
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- Citations: 21
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