Imperial College London
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ProfessorJ SimonKroll

Faculty of Medicine, Department of Infectious Disease

Emeritus Professor,Paediatrics&Molecular Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3695s.kroll

 
 
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Assistant

 

Dr Robert Boyle +44 (0)20 7594 3990

 
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Location

 

245Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Faraday:2018:10.1080/14767058.2018.1494147,
author = {Faraday, C and Hamad, S and Jones, KD and Sim, K and Cherian, S and James, A and Godambe, S and New, HV and Kroll, JS and Clarke, P},
doi = {10.1080/14767058.2018.1494147},
journal = {Journal of Maternal-Fetal and Neonatal Medicine},
pages = {398--403},
title = {Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK},
url = {http://dx.doi.org/10.1080/14767058.2018.1494147},
volume = {33},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND AIMS: The etiology of necrotizing enterocolitis (NEC) is unclear and postulated as being multifactorial. It has been suggested that one causative factor is the transfusion of packed red blood cells (PRBCs) leading to the disease entity commonly referred to as transfusion-associated NEC (TANEC). TANEC has been reported in North America but its incidence has not been formally investigated in the UK. Our aims were to identify the incidence of NEC and TANEC in tertiary-level UK neonatal units and to describe characteristics of TANEC cases. MATERIALS AND METHODS: Using strict case definitions for NEC and TANEC, we undertook a retrospective review to estimate the incidence of TANEC cases occurring in four UK tertiary-level centers during a 38-month period. RESULTS: Of 8007 consecutive neonatal admissions of all gestations to the four centers, 68 babies went on to develop NEC and all affected infants were of very low birth weight (VLBW); 34 of these had previously received a transfusion of PRBCs but did not fit the diagnostic criteria for TANEC, whereas 15 (22%) of the 68 babies with NEC qualified as TANEC cases. UK cases occurred at an earlier postnatal age than cases reported in multiple large North American series and were of a lower birth weight. CONCLUSIONS: We have confirmed the presence of TANEC in the UK VLBW neonatal population. Its incidence lies within the wide range described in previous reports of this phenomenon globally, though with some local variation in characteristics. Further work is needed to clarify causation, pathophysiology, and possible mechanisms of prevention of TANEC.
AU  - Faraday,C
AU  - Hamad,S
AU  - Jones,KD
AU  - Sim,K
AU  - Cherian,S
AU  - James,A
AU  - Godambe,S
AU  - New,HV
AU  - Kroll,JS
AU  - Clarke,P
DO  - 10.1080/14767058.2018.1494147
EP  - 403
PY  - 2018///
SN  - 1476-4954
SP  - 398
TI  - Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK
T2  - Journal of Maternal-Fetal and Neonatal Medicine
UR  - http://dx.doi.org/10.1080/14767058.2018.1494147
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29945481
UR  - http://hdl.handle.net/10044/1/67671
VL  - 33
ER  -
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